CASKIN1 - CASK interacting protein 1 Gene

Homo sapiens

Also known as ANKS5A

Gene ID: 57524 | Gene type: protein coding

About CASKIN1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,177,180-2,196,605 (from NCBI)

This gene has 3 transcripts (splice variants), 254 orthologues and 1 paralogue. Broad expression in brain (RPKM 9.2), colon (RPKM 2.0) and 23 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm and membrane. [provided by Alliance of Genome Resources, Apr 2022]

CASKIN1 Products(1)

mRNA	Protein	Name
NM_020764.4	NP_065815.1	caskin-1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21763699	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21763699	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASKIN1 Protein Structure

Ank_5

Ank_2

SH3_2

SAM_1

0
300
600
900
1200
1431 a.a.

Protein Preferred Names

Protein Names

caskin-1

CASKIN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CASKIN1	Q8WXD9	CASK	Homo sapiens	O14936	GMS	21763699
Intra	CASKIN1	Q8WXD9	CASK	Homo sapiens	O14936	BN-PAGE	21763699
Intra	CASKIN1	Q8WXD9	CASK	Homo sapiens	O14936	SPR	21763699
Intra	CASKIN1	Q8WXD9	CASK	Homo sapiens	O14936-2	TEM	22153505
Intra	CASKIN1	Q8WXD9	CASK	Homo sapiens	O14936-2	Solution Sedimentation	22153505
Intra	CASKIN1	Q8WXD9	CASKIN1	Homo sapiens	Q8WXD9	SPR	22153505
Intra	CASKIN1	Q8WXD9	CASKIN1	Homo sapiens	Q8WXD9	TEM	22153505
Intra	CASKIN1	Q8WXD9	CASKIN1	Homo sapiens	Q8WXD9	X-Ray Diffraction	22153505
Intra	CASKIN1	Q8WXD9	CASKIN1	Homo sapiens	Q8WXD9	BN-PAGE	21763699
Intra	CASKIN1	Q8WXD9	CASKIN1	Homo sapiens	Q8WXD9	GMS	22153505
Intra	CASKIN1	Q8WXD9	CASKIN1	Homo sapiens	Q8WXD9	LM	22153505

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Syndromic X-Linked Intellectual Disability Najm Type

Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia	Micpch
X-Linked Intellectual Disability-Microcephaly-Pontocerebellar Hypoplasia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115719	CASK-IN-1	Inhibitor	99.7%	Unkown
HY-RS01939	CASKIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CASKIN1	RGD	RGD:620191
Macaca mulatta	CASKIN1	VGNC	VGNC:70593
Felis catus	CASKIN1	VGNC	VGNC:82359
Bos taurus	CASKIN1	VGNC	VGNC:26777
Canis familiaris	CASKIN1	VGNC	VGNC:38730
Mus musculus	CASKIN1	MGD	MGI:2442952

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