ZBTB2 - zinc finger and BTB domain containing 2 Gene

Homo sapiens

Also known as ZNF437

Gene ID: 57621 | Gene type: protein coding

About ZBTB2

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:151,364,115-151,391,559 (from NCBI)

This gene has 1 transcript (splice variant) and 210 orthologues. Ubiquitous expression in thyroid (RPKM 17.1), lymph node (RPKM 6.4) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB2 Products(1)

mRNA	Protein	Name
NM_020861.3	NP_065912.1	zinc finger and BTB domain-containing protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19380588	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	25609694	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25609694	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19380588	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB2 Protein Structure

BTB

zf-C2H2

zf-H2C2_2

zf-C2H2

0
100
200
300
400
514 a.a.

Protein Preferred Names

Protein Names

zinc finger and BTB domain-containing protein 2

ZBTB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZBTB2	Q8N680	MKLN1	Homo sapiens	Q9UL63	Validated Y2H	32296183
Intra	ZBTB2	Q8N680	RASSF8	Homo sapiens	Q8NHQ8-2	Validated Y2H	32296183
Intra	ZBTB2	Q8N680	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ZBTB2	Q8N680	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ZBTB2	Q8N680	ZNF639	Homo sapiens	Q9UID6	Y2H Prey Pooling	32296183
Intra	ZBTB2	Q8N680	ZNF639	Homo sapiens	Q9UID6	Anti Tag CoIP	33961781
Intra	ZBTB2	Q8N680	SP1	Homo sapiens	P08047	Anti Bait CoIP	25609694
Intra	ZBTB2	Q8N680	ZNF639	Homo sapiens	Q9UID6	Validated Y2H	32296183
Intra	ZBTB2	Q8N680	ZBTB25	Homo sapiens	P24278	Anti Tag CoIP	33961781
Intra	ZBTB2	Q8N680	ZNF639	Homo sapiens	Q9UID6	Y2H Array	32296183
Intra	ZBTB2	Q8N680	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	32296183
Intra	ZBTB2	Q8N680	LHX4	Homo sapiens	Q969G2	Validated Y2H	32296183
Intra	ZBTB2	Q8N680	LHX4	Homo sapiens	Q969G2	Y2H Array	32296183
Intra	ZBTB2	Q8N680	ZBTB18	Homo sapiens	Q99592	Y2H Prey Pooling	32296183
Intra	ZBTB2	Q8N680	ZBTB18	Homo sapiens	Q99592	Validated Y2H	32296183
Intra	ZBTB2	Q8N680	ZBTB18	Homo sapiens	Q99592	Y2H Array	32296183
Intra	ZBTB2	Q8N680	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	ZBTB2	Q8N680	MRPL11	Homo sapiens	Q9Y3B7	Validated Y2H	32296183
Intra	ZBTB2	Q8N680	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	ZBTB2	Q8N680	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
Intra	ZBTB2	Q8N680	IP6K2	Homo sapiens	Q9UHH9	Validated Y2H	32296183
Intra	ZBTB2	Q8N680	TENT5B	Homo sapiens	Q96A09	Validated Y2H	32296183
Intra	ZBTB2	Q8N680	DAXX	Homo sapiens	Q9UER7	Validated Y2H	32296183
Intra	ZBTB2	Q8N680	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	ZBTB2	Q8N680	TMC6	Homo sapiens	Q7Z403	Y2H Array	32296183
Intra	ZBTB2	Q8N680	TMC6	Homo sapiens	Q7Z403	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 10

RP10	Retinitis Pigmentosa-10
Retinitis Pigmentosa, Type 10

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15967	ZBTB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZBTB2	VGNC	VGNC:37064
Canis familiaris	ZBTB2	VGNC	VGNC:54005
Felis catus	ZBTB2	VGNC	VGNC:102550
Mus musculus	ZBTB2	MGD	MGI:2685949
Rattus norvegicus	ZBTB2	RGD	RGD:1306621
Macaca mulatta	ZBTB2	VGNC	VGNC:79291
Others	ZBTB2	NCBI

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