IP6K2 - inositol hexakisphosphate kinase 2 Gene

Homo sapiens

Also known as PIUS; IHPK2; InsP6K2

Gene ID: 51447 | Gene type: protein coding

About IP6K2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,688,003-48,717,221 (from NCBI)

This gene has 28 transcripts (splice variants), 267 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 16.6), skin (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

IP6K2 Products(8)

mRNA	Protein	Name
NM_001005909.3	NP_001005909.1	inositol hexakisphosphate kinase 2 isoform a
NM_001005910.3	NP_001005910.1	inositol hexakisphosphate kinase 2 isoform b
NM_001005911.3	NP_001005911.1	inositol hexakisphosphate kinase 2 isoform b
NM_001146178.3	NP_001139650.1	inositol hexakisphosphate kinase 2 isoform c
NM_001146179.3	NP_001139651.1	inositol hexakisphosphate kinase 2 isoform c
NM_001190316.2	NP_001177245.1	inositol hexakisphosphate kinase 2 isoform d
NM_001190317.2	NP_001177246.1	inositol hexakisphosphate kinase 2 isoform e
NM_016291.4	NP_057375.2	inositol hexakisphosphate kinase 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables flavonoid binding	IDA IDA: Inferred from direct assay	30624931	GOA
enables inositol hexakisphosphate 5-kinase activity	IDA IDA: Inferred from direct assay	30624931	GOA
enables inositol hexakisphosphate kinase activity	IDA IDA: Inferred from direct assay	10574768	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18195352	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to flavonoid	IMP IMP: Inferred from mutant phenotype	30624931	GOA
involved in inositol phosphate metabolic process	IDA IDA: Inferred from direct assay	30624931	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	11337497	GOA
involved in phosphatidylinositol phosphate biosynthetic process	IDA IDA: Inferred from direct assay	10574768	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11337497	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11502751	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IP6K2 Protein Structure

IPK

0
100
200
300
400
426 a.a.

Protein Preferred Names

Protein Names

inositol hexakisphosphate kinase 2

ATP:1D-myo-inositol-hexakisphosphate phosphotransferase

IP6K2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IP6K2	Q9UHH9	PGK2	Homo sapiens	P07205	Anti Tag CoIP	33961781
Intra	IP6K2	Q9UHH9	PGK2	Homo sapiens	P07205	Anti Tag CoIP	28514442
Intra	IP6K2	Q9UHH9	LNX2	Homo sapiens	Q8N448	Y2H Array	29892012
Intra	IP6K2	Q9UHH9	LNX2	Homo sapiens	Q8N448	Y2H Array	31515488
Intra	IP6K2	Q9UHH9	ZBTB2	Homo sapiens	Q8N680	Y2H Prey Pooling	32296183
Intra	IP6K2	Q9UHH9	ZBTB2	Homo sapiens	Q8N680	Y2H Array	32296183
Intra	IP6K2	Q9UHH9	TP53	Homo sapiens	P04637	Pull Down	21078964
Intra	IP6K2	Q9UHH9	TP53	Homo sapiens	P04637	Anti Bait CoIP	21078964
Intra	IP6K2	Q9UHH9	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956
Intra	IP6K2	Q9UHH9	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	IP6K2	Q9UHH9	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150607	UNC7467		98.07%	Unkown
HY-153530	LI-2242		98.95%	Unkown
HY-122706	TBK1/IKKε-IN-3		/	Unkown
HY-RS06862	IP6K2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-161032	IP6K2-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IP6K2	VGNC	VGNC:62952
Mus musculus	IP6K2	MGD	MGI:1923750
Macaca mulatta	IP6K2	VGNC	VGNC:73612
Rattus norvegicus	IP6K2	RGD	RGD:620529
Canis familiaris	IP6K2	VGNC	VGNC:42062
Bos taurus	IP6K2	VGNC	VGNC:30238

Name
Email *

	Sorry, but the email address you supplied was invalid.