PTPN2 - protein tyrosine phosphatase non-receptor type 2 Gene

Homo sapiens

Also known as PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP

Gene ID: 5771 | Gene type: protein coding

About PTPN2

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:12,785,478-12,884,237 (from NCBI)

This gene has 21 transcripts (splice variants), 284 orthologues, 35 paralogues and is associated with 4 phenotypes. Ubiquitous expression in appendix (RPKM 7.7), lymph node (RPKM 7.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

PTPN2 Products(5)

mRNA	Protein	Name
NM_001207013.2	NP_001193942.1	tyrosine-protein phosphatase non-receptor type 2 isoform 4
NM_001308287.1	NP_001295216.1	tyrosine-protein phosphatase non-receptor type 2 isoform 5
NM_002828.4	NP_002819.2	tyrosine-protein phosphatase non-receptor type 2 isoform 1
NM_080422.3	NP_536347.1	tyrosine-protein phosphatase non-receptor type 2 isoform 2
NM_080423.3	NP_536348.1	tyrosine-protein phosphatase non-receptor type 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	15592458	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12359225	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11909529	GOA
enables protein tyrosine phosphatase activity	EXP EXP: Inferred from Experiment	12138178	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	12138178	GOA
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	11909529	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	18819921	GOA
enables syntaxin binding	IPI IPI: Inferred from physical interaction	23006999	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15592458	GOA
involved in negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15592458	GOA
involved in negative regulation of interleukin-2-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11909529	GOA
involved in negative regulation of interleukin-4-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	17210636	GOA
involved in negative regulation of interleukin-6-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12359225	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11909529	GOA
NOT involved in negative regulation of type II interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	12138178	GOA
involved in negative regulation of type II interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12138178	GOA
involved in negative regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	12359225	GOA
involved in peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	11909529	GOA
involved in regulation of hepatocyte growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18819921	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	7593185	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	23006999	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7593185	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	15592458	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN2 Protein Structure

Y_phosphatase

0
100
200
300
415 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 2

T-cell protein tyrosine phosphatase

PTPN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPN2	P17706	COL5A1	Homo sapiens	P20908	Anti Tag CoIP	33961781
Intra	PTPN2	P17706	COL5A1	Homo sapiens	P20908	Anti Tag CoIP	28514442
Cross	PTPN2	P17706	q2ghu2_ehrcr	Ehrlichia chaffeensis	Q2GHU2	Confocal	19273555
Intra	PTPN2	P17706	GHR	Homo sapiens	P10912	Array	12907755

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76103	TCPTP Protein, Human (sf9)	P17706-1 (N-G&P, M1-N314)	≥95%
HY-P76104	TCPTP Protein, Human (sf9, His-GST)	P17706-1 (M1-N314)	≥95%

Related Diseases

Diseases

Alias

Oligoarticular Juvenile Idiopathic Arthritis

Oligoarticular Jia	Pauciarticular Chronic Arthritis
Juvenile Pauciarticular Chronic Arthritis

Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis

Juvenile Polyarthritis Without Rheumatoid Factor	Juvenile Rheumatoid Factor-Negative Polyarthritis
Rheumatoid Factor-Negative Polyarticular Jia	Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative

Inflammatory Bowel Disease 20

IBD20

Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1	IBD1
Crohn Disease-Associated Growth Failure	Crohn Disease
Regional Enteritis	Ulcerative Colitis
Crohn Disease-Associated Growth Failure, Susceptibility To	Inflammatory Bowel Disease 1, Crohn Disease
Bowel Disease, Inflammatory, Type 1

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Diabetes Mellitus

Diabetes

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145923	Osunprotafib	Inhibitor	99.43%	Unkown
HY-148691	PROTAC PTPN2 degrader-1	Degrader	95.01%	Unkown
HY-153638	PTPN2/1-IN-2	Antagonist	99.56%	Unkown
HY-153446	Tegeprotafib	Inhibitor	98.12%	Unkown
HY-118925	Holothurin A	Inhibitor	/	Unkown
HY-149760	PVD-06	Inhibitor	/	Unkown
HY-153938	PROTAC PTPN2 degrader-2		/	Unkown
HY-153938A	PROTAC PTPN2 degrader-2 TFA		/	Unkown
HY-156606	Anticancer agent 142	Inhibitor	/	Unkown
HY-156607	Anticancer agent 143	Inhibitor	/	Unkown
HY-156608	Anticancer agent 144	Inhibitor	/	Unkown
HY-162428	PTPN2/1-IN-3	Inhibitor	/	Unkown
HY-163596	PTPN2-IN-1	Inhibitor	/	Unkown
HY-168691	PTPN2 ligand 1		/	Unkown
HY-RS11421	PTPN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PTPN2	VGNC	VGNC:33534
Mus musculus	PTPN2	MGD	MGI:97806
Felis catus	PTPN2	VGNC	VGNC:80468
Rattus norvegicus	PTPN2	RGD	RGD:620710
Canis familiaris	PTPN2	VGNC	VGNC:45172
Macaca mulatta	PTPN2	VGNC	VGNC:104236
Others	PTPN2	NCBI

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