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  2. ZP4 - zona pellucida glycoprotein 4 Gene

ZP4 - zona pellucida glycoprotein 4 Gene

Homo sapiens

Also known as ZBP; ZP1; ZPB; ZP1B; ZPB2; Zp-4

Gene ID: 57829 | Gene type: protein coding

About ZP4

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:237,882,404-237,890,922 (from NCBI)

This gene has 2 transcripts (splice variants), 186 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus Furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that Furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for Furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008]

ZP4 Products(1)

mRNA Protein Name
NM_021186.5 NP_067009.1 zona pellucida sperm-binding protein 4 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables acrosin binding IPI
IPI: Inferred from physical interaction
15950651 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
26879157 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15950651 GOA
Biological Process GO Annotation Evidence Reference Source
involved in acrosomal vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
19004505 GOA
involved in negative regulation of binding of sperm to zona pellucida IDA
IDA: Inferred from direct assay
18667750 GOA
involved in positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
19004505 GOA
involved in positive regulation of acrosome reaction IDA
IDA: Inferred from direct assay
18667750 GOA
involved in positive regulation of humoral immune response IDA
IDA: Inferred from direct assay
19004505 GOA
Cellular Component GO Annotation Evidence Reference Source
located in egg coat IDA
IDA: Inferred from direct assay
29895852 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZP4 Protein Structure

Trefoil

Trefoil: Trefoil (P-type) domain (143 - 182)

Zona_pellucida

Zona_pellucida: Zona pellucida-like domain (188 - 460)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 540 a.a.
Protein Preferred Names Protein Names

zona pellucida sperm-binding protein 4

zona pellucida protein B

ZP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZP4 Q12836 GPX4 Homo sapiens P36969 23355646
Intra
ZP4 Q12836 ZP4 Homo sapiens Q12836
EM
26879157
Intra
ZP4 Q12836 ZP4 Homo sapiens Q12836 26879157
Intra
ZP4 Q12836 GSTM3 Homo sapiens P21266 23355646
Intra
ZP4 Q12836 GAPDHS Homo sapiens O14556 23355646
Intra
ZP4 Q12836 ACR Homo sapiens P10323 15950651
Intra
ZP4 Q12836 GSTM3 Homo sapiens P21266 23355646
Intra
ZP4 Q12836 ODF2 Homo sapiens Q5BJF6-5 23355646
Intra
ZP4 Q12836 ALDOA Homo sapiens P04075 23355646
Intra
ZP4 Q12836 ZP4 Homo sapiens Q12836 26879157
Intra
ZP4 Q12836 ENO1 Homo sapiens P06733 23355646
Intra
ZP4 Q12836 P10323-PRO_0000027518 Homo sapiens P10323-PRO_0000027518 15950651
Intra
ZP4 Q12836 PKM Homo sapiens P14618-2 23355646
Intra
ZP4 Q12836 TPI1 Homo sapiens P60174-1 23355646
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ovarian Dysgenesis 2

Premature Ovarian Failure 4

ODG2

Ovarian Dysgenesis, Hypergonadotropic, X-Linked

Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis

Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis

X-Linked Hypergonadotropic Ovarian Dysgenesis

POF4

Dysgenesis, Ovarian, Type 2

Cataract 1, Multiple Types

Cataract 1 Multiple Types

CTRCT1

Cataract 1, Multiple Types, With Or Without Microcornea

Czp1

Cae1

Pulverulent Zonular Cataract

Cataract, Duffy-Linked

Cataract, Zonular Pulverulent, 1

Duffy Linked Cataract

Zonular Pulverulent Cataract 1

Cataract Duffy-Linked

Cataract-Microcornea Syndrome

Cataract Zonular Pulverulent 1

Ccmc

Cznp

Czp

Zonular Nuclear Pulverulent Cataract

Cataract, Zonular Pulverulent-1

Zonular Pulverulent Cataract

Cataract, Zonular Pulverulent 1

Cataract Microcornea Syndrome

Voyeurism
Usher Syndrome, Type Iiia

Usher Syndrome Type 3

Ush3

Usher Syndrome Type 3a

USH3A

Usher Syndrome, Type Iii

Usher Syndrome, Type 3

Usher Syndrome, Type 3a

Usher Syndrome Type Iiia

Usher Syndrome 3a

Usher'S Syndrome Type 3

Usher Syndrome Iii

Usher Syndrome Type Iii

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E

Primary Open Angle Glaucoma

POAG

Adult-Onset Primary Open Angle Glaucoma

Chronic Simple Glaucoma

GLC1E

Primary Open Angle Glaucoma 1e

Glaucoma, Open Angle, Primary

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZP4 VGNC VGNC:78985
Rattus norvegicus ZP4 RGD RGD:628708
Felis catus ZP4 VGNC VGNC:67374
Bos taurus ZP4 VGNC VGNC:37367
Canis familiaris ZP4 VGNC VGNC:48843