GSTM3 - glutathione S-transferase mu 3 Gene

Homo sapiens

Also known as GST5; GSTB; GTM3; GSTM3-3; hGSTM3-3

Gene ID: 2947 | Gene type: protein coding

About GSTM3

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,733,937-109,741,038 (from NCBI)

This gene has 5 transcripts (splice variants), 258 orthologues, 11 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 82.2), kidney (RPKM 34.8) and 16 other tissues.

Summary

Cytosolic and membrane-bound forms of Glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a Glutathione S-transferase that belongs to the mu class. The mu class of Enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of Enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

GSTM3 Products(1)

mRNA	Protein	Name
NM_000849.5	NP_000840.2	glutathione S-transferase Mu 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	8373352	GOA
enables glutathione binding	IDA IDA: Inferred from direct assay	8373352	GOA
enables glutathione transferase activity	IDA IDA: Inferred from direct assay	8373352	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23355646	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	9545290	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	8373352	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular detoxification of nitrogen compound	IDA IDA: Inferred from direct assay	8373352	GOA
involved in glutathione metabolic process	IDA IDA: Inferred from direct assay	8373352	GOA
involved in nitrobenzene metabolic process	IDA IDA: Inferred from direct assay	8373352	GOA
involved in response to estrogen	IEP IEP: Inferred from expression pattern	10037815	GOA
involved in xenobiotic catabolic process	IDA IDA: Inferred from direct assay	8373352	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8373352	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSTM3 Protein Structure

GST_N

GST_C

0
100
200
225 a.a.

Protein Preferred Names

Protein Names

glutathione S-transferase Mu 3

GST class-mu 3

GSTM3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GSTM3	P21266	CLVS2	Homo sapiens	Q5SYC1	Validated Y2H	32296183
Intra	GSTM3	P21266	CLVS2	Homo sapiens	Q5SYC1	Y2H Prey Pooling	32296183
Intra	GSTM3	P21266	CLVS2	Homo sapiens	Q5SYC1	Y2H Array	32296183
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H Array	19060904
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H Pooling	16189514
Intra	GSTM3	P21266	GSTM5	Homo sapiens	P46439	Y2H Prey Pooling	32296183
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Validated Y2H	32296183
Intra	GSTM3	P21266	GSTM4	Homo sapiens	Q03013	Y2H Prey Pooling	32296183
Intra	GSTM3	P21266	GSTM5	Homo sapiens	P46439	Validated Y2H	32296183
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H Array	32296183
Intra	GSTM3	P21266	GSTM5	Homo sapiens	P46439	Y2H Array	32296183
Intra	GSTM3	P21266	GSTM5	Homo sapiens	P46439	MAPPIT	32296183
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H Prey Pooling	32296183
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H	21516116
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H Array	31515488
Intra	GSTM3	P21266	GSTM5	Homo sapiens	P46439	Complementation	32296183
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H Pooling	19060904
Intra	GSTM3	P21266	GSTM5	Homo sapiens	P46439	Y2H Array	31515488
Intra	GSTM3	P21266	GSTM4	Homo sapiens	Q03013	Validated Y2H	32296183
Intra	GSTM3	P21266	GSTM4	Homo sapiens	Q03013	Y2H Array	32296183
Intra	GSTM3	P21266	GSTM4	Homo sapiens	Q03013	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Larynx Cancer

Laryngeal Carcinoma	Laryngeal Cancer
Laryngeal Neoplasm	Carcinoma Of Larynx
Malignant Neoplasm Of Larynx	Cancer Of Larynx
Laryngeal Neoplasms	Cancer, Laryngeal

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Pharynx Cancer

Pharyngeal Cancer	Pharyngeal Neoplasms
Pharyngeal Neoplasm	Pharynx Neoplasm
Malignant Neoplasm Of Pharynx	Pharyngeal Carcinoma

Laryngeal Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Larynx	Squamous Cell Carcinoma Of Larynx
Squamous Cell Carcinoma Of The Larynx	Squamous Cell Carcinoma Of Head And Neck

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Open-Angle Glaucoma

Glaucoma Simplex	Pigmentary Glaucoma
Wide-Angle Glaucoma	Glaucoma, Open-Angle
Open Angle Glaucoma	Glaucoma Open-Angle
Chronic Simple Glaucoma	Coag - [Chronic Open-Angle Glaucoma]
Csg - [Chronic Simple Glaucoma]	Poag - [Primary Open-Angle Glaucoma]
Oag - [Open-Angle Glaucoma]	Chronic Glaucoma
Chronic Open Angle Glaucoma	Simple Glaucoma
Chronic Noncongestive Glaucoma	Ltg - [Low Tension Glaucoma]
Noncongestive Glaucoma	Nonobstructive Glaucoma
Normal Pressure Glaucoma	Primary Low Tension Glaucoma
Low-Tension Glaucoma	Residual Stage Low Tension Glaucoma
Open Cleft Glaucoma

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Lip And Oral Cavity Cancer

Oral Cancer	Lip And Oral Cavity Carcinoma
Malignant Neoplasm Of Mouth

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146577	Keap1-Nrf2-IN-7	Inhibitor	/	Unkown
HY-146578	Keap1-Nrf2-IN-8	Inhibitor	/	Unkown
HY-149245	Keap1-Nrf2-IN-15	Inhibitor	/	Unkown
HY-RS05881	GSTM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-162096	Keap1-Nrf2-IN-17	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GSTM3	MGD	MGI:1309466
Rattus norvegicus	GSTM3	RGD	RGD:61964
Canis familiaris	GSTM3	VGNC	VGNC:54033
Felis catus	GSTM3	VGNC	VGNC:108363
Bos taurus	GSTM3	VGNC	VGNC:29686
Macaca mulatta	GSTM3	VGNC	VGNC:73303

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