CREBZF - CREB/ATF bZIP transcription factor Gene

Homo sapiens

Also known as ZF; SMILE

Gene ID: 58487 | Gene type: protein coding

About CREBZF

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:85,657,990-85,682,863 (from NCBI)

This gene has 10 transcripts (splice variants) and 157 orthologues. Ubiquitous expression in endometrium (RPKM 18.3), spleen (RPKM 18.1) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in negative regulation of gene expression, epigenetic; regulation of transcription, DNA-templated; and response to virus. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CREBZF Products(1)

mRNA	Protein	Name
NM_001039618.4	NP_001034707.1	CREB/ATF bZIP transcription factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16343488	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10871379	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15705566	GOA
involved in negative regulation of gene expression, epigenetic	IEP IEP: Inferred from expression pattern	15705566	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16343488	GOA
involved in regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15705566	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10871379	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	10871379	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	23661758	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15705566	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CREBZF Protein Structure

bZIP_1

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

CREB/ATF bZIP transcription factor

HCF-binding transcription factor Zhangfei

Related Diseases

Diseases

Alias

Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma	Adult Hepatoma
Adult Hcc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03160	CREBZF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CREBZF	VGNC	VGNC:39604
Bos taurus	CREBZF	VGNC	VGNC:27701
Macaca mulatta	CREBZF	VGNC	VGNC:71538
Felis catus	CREBZF	VGNC	VGNC:105836
Mus musculus	CREBZF	MGD	MGI:2675296
Rattus norvegicus	CREBZF	RGD	RGD:1565584

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