2. Gene
  3. CREBZF - CREB/ATF bZIP transcription factor Gene

CREBZF - CREB/ATF bZIP transcription factor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZF; SMILE

Gene ID: 58487 | Gene type: protein coding

About CREBZF

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:85,657,990-85,682,863 (from NCBI)

This gene has 10 transcripts (splice variants) and 157 orthologues. Ubiquitous expression in endometrium (RPKM 18.3), spleen (RPKM 18.1) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in negative regulation of gene expression, epigenetic; regulation of transcription, DNA-templated; and response to virus. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CREBZF Products(1)

mRNA Protein Name
NM_001039618.4 NP_001034707.1 CREB/ATF bZIP transcription factor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16343488 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10871379 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15705566 GOA
involved in negative regulation of gene expression, epigenetic IEP
IEP: Inferred from expression pattern
15705566 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16343488 GOA
involved in regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15705566 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10871379 GOA
involved in response to virus IDA
IDA: Inferred from direct assay
10871379 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
23661758 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15705566 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CREBZF Protein Structure

bZIP_1

bZIP_1: bZIP transcription factor (217 - 264)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

CREB/ATF bZIP transcription factor

HCF-binding transcription factor Zhangfei

CREBZF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CREBZF Q9NS37 ACYP2 Homo sapiens P14621
Validated Y2H
25416956
Intra
CREBZF Q9NS37 ACYP2 Homo sapiens P14621
Y2H Prey Pooling
25416956
Intra
CREBZF Q9NS37 SIRT1 Homo sapiens Q96EB6
Anti Bait CoIP
19690166
Intra
CREBZF Q9NS37 SIRT1 Homo sapiens Q96EB6
Pull Down
19690166
Intra
CREBZF Q9NS37 HCFC1 Homo sapiens P51610-4
Y2H Prey Pooling
32296183
Intra
CREBZF Q9NS37 NFE2L1 Homo sapiens Q14494
Peptide Array
20102225
Intra
CREBZF Q9NS37 NFE2L1 Homo sapiens Q14494
FRET
23661758
Intra
CREBZF Q9NS37 HCFC1 Homo sapiens P51610
Anti Bait CoIP
15705566
Intra
CREBZF Q9NS37 HCFC1 Homo sapiens P51610
Transcription Compl
10871379
Intra
CREBZF Q9NS37 HCFC1 Homo sapiens P51610
Pull Down
18391022
Intra
CREBZF Q9NS37 HCFC1 Homo sapiens P51610
Pull Down
10871379
Intra
CREBZF Q9NS37 ATF4 Homo sapiens P18848
Peptide Array
20102225
Intra
CREBZF Q9NS37 ATF4 Homo sapiens P18848
Anti Bait CoIP
16343488
Intra
CREBZF Q9NS37 ATF4 Homo sapiens P18848
FRET
23661758
Intra
CREBZF Q9NS37 ATF4 Homo sapiens P18848
Complementation
16343488
Cross
CREBZF Q9NS37 Esrrg Mus musculus P62509
Confocal
19690166
Cross
CREBZF Q9NS37 Esrrg Mus musculus P62509
Pull Down
19690166
Intra
CREBZF Q9NS37 CREB3 Homo sapiens O43889
FRET
23661758
Intra
CREBZF Q9NS37 CREB3 Homo sapiens O43889
Anti Bait CoIP
15705566
Intra
CREBZF Q9NS37 CREBZF Homo sapiens Q9NS37
Pull Down
19690166
Intra
CREBZF Q9NS37 CREBZF Homo sapiens Q9NS37
Pull Down
16343488
Intra
CREBZF Q9NS37 CREBZF Homo sapiens Q9NS37
Peptide Array
20102225
Intra
CREBZF Q9NS37 CREBZF Homo sapiens Q9NS37
FRET
23661758
Intra
CREBZF Q9NS37 CREBZF Homo sapiens Q9NS37
Complementation
16343488
Intra
CREBZF Q9NS37 TTC23 Homo sapiens Q5W5X9
Y2H Prey Pooling
25416956
Intra
CREBZF Q9NS37 TTC23 Homo sapiens Q5W5X9
Y2H Array
25416956
Intra
CREBZF Q9NS37 XBP1 Homo sapiens P17861
FRET
23661758
Intra
CREBZF Q9NS37 XBP1 Homo sapiens P17861
Peptide Array
20102225
Intra
CREBZF Q9NS37 CTNNBL1 Homo sapiens Q8WYA6
Y2H Prey Pooling
25416956
Cross
CREBZF Q9NS37 HBZ Human T-cell leukemia virus 1 P0C746
Peptide Array
20102225
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma

Adult Hepatoma

Adult Hcc
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03160 CREBZF Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CREBZF VGNC VGNC:39604
Bos taurus CREBZF VGNC VGNC:27701
Macaca mulatta CREBZF VGNC VGNC:71538
Felis catus CREBZF VGNC VGNC:105836
Mus musculus CREBZF MGD MGI:2675296
Rattus norvegicus CREBZF RGD RGD:1565584