INIP - INTS3 and NABP interacting protein Gene

Homo sapiens

Also known as MISE; SOSSC; SSBIP1; C9orf80; HSPC043; hSSBIP1

Gene ID: 58493 | Gene type: protein coding

About INIP

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:112,683,926-112,718,117 (from NCBI)

This gene has 6 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in lymph node (RPKM 8.2), colon (RPKM 6.8) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016]

INIP Products(7)

mRNA	Protein	Name
NM_001329585.2	NP_001316514.1	SOSS complex subunit C isoform b
NM_001329586.2	NP_001316515.1	SOSS complex subunit C isoform c
NM_001329587.2	NP_001316516.1	SOSS complex subunit C isoform d
NM_001329588.2	NP_001316517.1	SOSS complex subunit C isoform e
NM_001329589.2	NP_001316518.1	SOSS complex subunit C isoform e
NM_001329590.2	NP_001316519.1	SOSS complex subunit C isoform e
NM_021218.3	NP_067041.1	SOSS complex subunit C isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19683501	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	19683501	GOA
involved in DNA repair	IMP IMP: Inferred from mutant phenotype	19605351	GOA
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	19683501	GOA
involved in mitotic G2/M transition checkpoint	IDA IDA: Inferred from direct assay	19683501	GOA
involved in response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	19605351	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SOSS complex	IDA IDA: Inferred from direct assay	18449195	GOA
part of SOSS complex	IPI IPI: Inferred from physical interaction	19683501	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19605351	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	19683501	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SOSS complex subunit C

SSB-interacting protein 1

INIP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	INIP	Q9NRY2	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	INIP	Q9NRY2	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	INIP	Q9NRY2	INTS3	Homo sapiens	Q68E01	Anti Bait CoIP	19683501
Intra	INIP	Q9NRY2	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	INIP	Q9NRY2	DGCR6L	Homo sapiens	Q9BY27	MAPPIT	32296183
Intra	INIP	Q9NRY2	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	INIP	Q9NRY2	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	INIP	Q9NRY2	BPIFA1	Homo sapiens	Q9NP55	Y2H Prey Pooling	32296183
Intra	INIP	Q9NRY2	BPIFA1	Homo sapiens	Q9NP55	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Narcissistic Personality Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06817	INIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	INIP	VGNC	VGNC:102940
Rattus norvegicus	INIP	RGD	RGD:1307983
Mus musculus	INIP	MGD	MGI:1913459
Bos taurus	INIP	VGNC	VGNC:30204
Canis familiaris	INIP	VGNC	VGNC:49804

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