INTS3 - integrator complex subunit 3 Gene

Homo sapiens

Also known as INT3; SOSSA; SOSS-A; C1orf60; C1orf193

Gene ID: 65123 | Gene type: protein coding

About INTS3

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,728,050-153,774,808 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele and 200 orthologues. Ubiquitous expression in testis (RPKM 20.6), ovary (RPKM 17.9) and 25 other tissues.

Summary

The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]

INTS3 Products(2)

mRNA	Protein	Name
NM_001324475.2	NP_001311404.1	integrator complex subunit 3
NM_023015.5	NP_075391.3	integrator complex subunit 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16239144	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	19683501	GOA
involved in DNA repair	IMP IMP: Inferred from mutant phenotype	19605351	GOA
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	19683501	GOA
involved in mitotic G2/M transition checkpoint	IDA IDA: Inferred from direct assay	19683501	GOA
involved in mitotic G2/M transition checkpoint	IMP IMP: Inferred from mutant phenotype	19683501	GOA
involved in response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	19605351	GOA
involved in snRNA processing	IDA IDA: Inferred from direct assay	16239144	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SOSS complex	IDA IDA: Inferred from direct assay	18449195	GOA
part of SOSS complex	IPI IPI: Inferred from physical interaction	19683501	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23904267	GOA
part of integrator complex	IDA IDA: Inferred from direct assay	16239144	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19683501	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	19683501	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INTS3 Protein Structure

Ints3

0
200
400
600
800
1042 a.a.

Protein Preferred Names

Protein Names

integrator complex subunit 3

SOSS complex subunit A

Related Diseases

Diseases

Alias

Gand Syndrome

Mrd18	GAND
Mental Retardation, Autosomal Dominant 18	Autosomal Dominant Non-Syndromic Intellectual Disability 18
Autosomal Dominant Intellectual Developmental Disorder 18	Autosomal Dominant Mental Retardation 18

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133702	Aniline-piperazine-C3-NH-Boc		/	Unkown
HY-RS06855	INTS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	INTS3	VGNC	VGNC:62944
Bos taurus	INTS3	VGNC	VGNC:30229
Macaca mulatta	INTS3	VGNC	VGNC:73659
Mus musculus	INTS3	MGD	MGI:2140050
Canis familiaris	INTS3	VGNC	VGNC:42052
Rattus norvegicus	INTS3	RGD	RGD:1304593

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