RBM25 - RNA binding motif protein 25 Gene

Homo sapiens

Also known as S164; NET52; RNPC7; Snu71; RED120; fSAP94

Gene ID: 58517 | Gene type: protein coding

About RBM25

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:73,058,534-73,123,899 (from NCBI)

This gene has 12 transcripts (splice variants) and 280 orthologues. Ubiquitous expression in bone marrow (RPKM 31.7), lymph node (RPKM 25.2) and 25 other tissues.

Summary

Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and regulation of apoptotic process. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

RBM25 Products(1)

mRNA	Protein	Name
NM_021239.3	NP_067062.1	RNA-binding protein 25

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA binding	IDA IDA: Inferred from direct assay	18663000	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18663000	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	18663000	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	18663000	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	18663000	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM25 Protein Structure

RRM_1

PWI

0
200
400
600
843 a.a.

Protein Preferred Names

Protein Names

RNA-binding protein 25

Arg/Glu/Asp-rich protein, 120 kDa

RBM25 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RBM25	P49756	SRRM4	Homo sapiens	A7MD48	Y2H Prey Pooling	32296183
Intra	RBM25	P49756	SRRM4	Homo sapiens	A7MD48	Y2H Array	32296183
Intra	RBM25	P49756	PRPF40A	Homo sapiens	O75400	Anti Tag CoIP	33961781
Intra	RBM25	P49756	PRPF40A	Homo sapiens	O75400	Anti Tag CoIP	35271311
Intra	RBM25	P49756	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	RBM25	P49756	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	RBM25	P49756	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Atrial Septal Defect 9

ASD9	Atrial Heart Septal Defect 9
Septal Defect, Atrial, Type 9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11743	RBM25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RBM25	VGNC	VGNC:80872
Macaca mulatta	RBM25	VGNC	VGNC:76521
Rattus norvegicus	RBM25	RGD	RGD:1308755
Bos taurus	RBM25	VGNC	VGNC:33794
Mus musculus	RBM25	MGD	MGI:1914289

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