LY6G6D - lymphocyte antigen 6 family member G6D Gene

Homo sapiens

Also known as G6D; NG25; LY6-D; MEGT1; C6orf23

Gene ID: 58530 | Gene type: protein coding

About LY6G6D

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,715,348-31,717,919 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 56 orthologues and 1 paralogue. Biased expression in prostate (RPKM 1.8), testis (RPKM 1.5) and 6 other tissues.

Summary

LY6G6D belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 Amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Apr 2009]

LY6G6D Products(1)

mRNA	Protein	Name
NM_021246.4	NP_067069.2	lymphocyte antigen 6 complex locus protein G6d precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	17008713	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with external side of plasma membrane	IDA IDA: Inferred from direct assay	17008713	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	17008713	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lymphocyte antigen 6 complex locus protein G6d

lymphocyte antigen 6 complex, locus G6D

Recombinant LY6G6D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71751	LY6G6D Protein, Human (P.pastoris, His)	O95868 (N20-S104)	≥95%

Related Diseases

Diseases

Alias

Glucosephosphate Dehydrogenase Deficiency

G6pd Deficiency	Glucose-6-Phosphate Dehydrogenase Deficiency
Deficiency Of Glucose-6-Phosphate Dehydrogenase	Glucose 6 Phosphate Dehydrogenase Deficiency
Deficiency Of G-6pd	G6pdd

Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency

Favism	Favism, Susceptibility To
Hemolytic Anemia, G6pd Deficient	Class I Glucose-6-Phosphate Dehydrogenase Deficiency
Class I G6pd Deficiency	Severe Hemolytic Anemia Due To G6pd Deficiency
Anemia, Non-Spherocytic Hemolytic, Due To G6pd Deficiency	NSHA
G6pd Deficient Hemolytic Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07899	LY6G6D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LY6G6D	VGNC	VGNC:106603
Rattus norvegicus	LY6G6D	RGD	RGD:1303064
Bos taurus	LY6G6D	VGNC	VGNC:54228
Mus musculus	LY6G6D	MGD	MGI:2148931
Macaca fascicularis	LY6G6D	NCBI
Others	LY6G6D	NCBI

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