RAB1A - RAB1A, member RAS oncogene family Gene

Homo sapiens

Also known as RAB1; YPT1

Gene ID: 5861 | Gene type: protein coding

About RAB1A

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:65,086,854-65,130,106 (from NCBI)

This gene has 6 transcripts (splice variants), 163 orthologues and 68 paralogues. Ubiquitous expression in kidney (RPKM 68.0), thyroid (RPKM 58.5) and 25 other tissues.

Summary

This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

RAB1A Products(2)

mRNA	Protein	Name
NM_004161.5	NP_004152.1	ras-related protein Rab-1A isoform 1
NM_015543.2	NP_056358.1	ras-related protein Rab-1A isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	17684057	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15186776	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in COPII-coated vesicle cargo loading	IMP IMP: Inferred from mutant phenotype	17684057	GOA
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	17684057	GOA
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	22939626	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	22939626	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	20639577	GOA
NOT involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	17646400	GOA
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	22939626	GOA
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	21303926	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IGI IGI: Inferred from genetic interaction	21680502	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	17684057	GOA
NOT involved in establishment of endothelial intestinal barrier	IMP IMP: Inferred from mutant phenotype	23885123	GOA
involved in growth hormone secretion	IMP IMP: Inferred from mutant phenotype	22939626	GOA
involved in positive regulation of glycoprotein metabolic process	IGI IGI: Inferred from genetic interaction	21680502	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	22939626	GOA
involved in vesicle transport along microtubule	IMP IMP: Inferred from mutant phenotype	21303926	GOA
involved in virion assembly	IGI IGI: Inferred from genetic interaction	21680502	GOA
involved in virion assembly	IMP IMP: Inferred from mutant phenotype	21680502	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17684057	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB1A Protein Structure

Ras

0
100
205 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-1A

GTP binding protein Rab1a

RAB1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB1A	P62820	RPTOR	Homo sapiens	Q8N122	Anti Bait CoIP	25446900
Intra	RAB1A	P62820	RPTOR	Homo sapiens	Q8N122	Anti Tag CoIP	25446900
Intra	RAB1A	P62820	RPTOR	Homo sapiens	Q8N122	PLA	25446900
Cross	RAB1A	P62820	drrA	Legionella pneumophila	Q29ST3	Anti Tag CoIP	30323948
Intra	RAB1A	P62820	C9orf72	Homo sapiens	Q96LT7-1	Pull Down	27334615
Intra	RAB1A	P62820	C9orf72	Homo sapiens	Q96LT7-1	Anti Tag CoIP	27334615
Intra	RAB1A	P62820	C9orf72	Homo sapiens	Q96LT7-2	Anti Tag CoIP	27334615
Intra	RAB1A	P62820	C9orf72	Homo sapiens	Q96LT7-2	Pull Down	27334615
Intra	RAB1A	P62820	MTOR	Homo sapiens	P42345	Anti Bait CoIP	25446900
Intra	RAB1A	P62820	MTOR	Homo sapiens	P42345	Anti Tag CoIP	25446900
Intra	RAB1A	P62820	MTOR	Homo sapiens	P42345	PLA	25446900
Intra	RAB1A	P62820	OCRL	Homo sapiens	Q01968	Pull Down	16902405
Intra	RAB1A	P62820	RABIF	Homo sapiens	P47224	Anti Tag CoIP	33961781
Intra	RAB1A	P62820	RABIF	Homo sapiens	P47224	Y2H Array	32296183
Cross	RAB1A	P62820	drrA	Legionella pneumophila subsp. pneumophila	Q5ZSQ3	Comig Non-Denat Gel	19942850
Cross	RAB1A	P62820	drrA	Legionella pneumophila subsp. pneumophila	Q5ZSQ3	X-Ray Diffraction	19942850
Cross	RAB1A	P62820	drrA	Legionella pneumophila subsp. pneumophila	Q5ZSQ3	ITC	19942850
Intra	RAB1A	P62820	GDI1	Homo sapiens	P31150	Anti Tag CoIP	35271311
Intra	RAB1A	P62820	GDI1	Homo sapiens	P31150	Pull Down	19942850
Intra	RAB1A	P62820	GDI1	Homo sapiens	P31150	Anti Tag CoIP	33961781
Intra	RAB1A	P62820	GDI1	Homo sapiens	P31150	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Choroideremia

CHM	Tcd
Progressive Tapetochoroidal Dystrophy	Choroidal Sclerosis
Tapetochoroidal Dystrophy, Progressive	Progressive Choroidal Atrophy
Tapetochoroidal Dystrophy

Spinocerebellar Ataxia, Autosomal Recessive 6

SCAR6	Norwegian Infantile Onset Ataxia
Autosomal Recessive Spinocerebellar Ataxia 6	Autosomal Recessive Spinocerebellar Ataxia Type 6
Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia	Cerebellar Ataxia, Infantile Nonprogressive, Autosomal Recessive
Spinocerebellar Ataxia Autosomal Recessive 6	Cerebellar Ataxia Infantile Nonprogressive Autosomal Recessive

Legionellosis

Legionella Infection	Pontiac Fever
Legionnaires' Disease	Infection By Legionella Pneumophilia
Legionella Pneumophila Infection

Esophageal Neuroendocrine Tumor

Esophageal Neuroendocrine Tumour	Neuroendocrine Tumor Of Esophagus
Neuroendocrine Tumour Of Oesophagus

Legionnaire Disease

Legionnaires' Disease	Legionnaires Disease
Legionnaire Disease, Susceptibility To	Legionella
Legionella Pneumonia	Infection By Legionella Pneumophilia
Legionnaire'S Disease	Legionellosis
Legionaire Disease, Susceptibility To	Legionnaires Pneumonia

Rectum Adenocarcinoma

Rectal Adenocarcinoma

Adenocarcinoma Of Rectum

Rectal Benign Neoplasm

Neoplasm Of Rectum	Rectal Tumor
Rectum Neoplasm	Neoplasm Of The Rectum
Rectal Neoplasms	Primary Rectal Cancer
Rectal Ampulla Cancer	Cancer Of The Rectum
Carcinoma Of Rectum	Primary Malignant Neoplasm Of Rectum
Rectal Cancer	Rectal Carcinoma

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1	Frontotemporal Dementia And/Or Motor Neuron Disease
Ftdmnd	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia
Alsftd	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1	Frontotemporal Dementia With Motor Neuron Disease
Ftdals	Ftd-Als
Ftd-Mnd	Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1	Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1
Frontotemporal Lobar Degeneration	Grn-Related Frontotemporal Dementia

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156242	BQZ-485	Inducer	/	Unkown
HY-RS11528	RAB1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAB1A	VGNC	VGNC:106204
Bos taurus	RAB1A	VGNC	VGNC:33626
Felis catus	RAB1A	VGNC	VGNC:81164
Mus musculus	RAB1A	MGD	MGI:97842
Canis familiaris	RAB1A	VGNC	VGNC:45259
Rattus norvegicus	RAB1A	RGD	RGD:619736

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