RAB27B - RAB27B, member RAS oncogene family Gene

Homo sapiens

Also known as C25KG

Gene ID: 5874 | Gene type: protein coding

About RAB27B

Cytogenetic location: 18q21.2 Genomic coordinates (GRCh38): 18:54,717,857-54,895,516 (from NCBI)

This gene has 4 transcripts (splice variants), 260 orthologues and 68 paralogues. Biased expression in stomach (RPKM 15.0), prostate (RPKM 9.9) and 13 other tissues.

Summary

Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]

RAB27B Products(2)

mRNA	Protein	Name
NM_001375327.1	NP_001362256.1	ras-related protein Rab-27B
NM_004163.4	NP_004154.2	ras-related protein Rab-27B

RAB27B Protein Structure

Ras

0
100
200
218 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-27B

RAB27B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB27B	O00194	SYTL5	Homo sapiens	Q8TDW5-2	Validated Y2H	32296183
Intra	RAB27B	O00194	RPH3A	Homo sapiens	Q9Y2J0-2	Validated Y2H	32296183
Intra	RAB27B	O00194	MYRIP	Homo sapiens	Q8NFW9	Y2H Prey Pooling	32296183
Intra	RAB27B	O00194	MYRIP	Homo sapiens	Q8NFW9	Validated Y2H	32296183
Intra	RAB27B	O00194	MYRIP	Homo sapiens	Q8NFW9	Y2H Array	32296183
Intra	RAB27B	O00194	RPH3AL	Homo sapiens	Q9UNE2	Validated Y2H	32296183
Intra	RAB27B	O00194	RPH3AL	Homo sapiens	Q9UNE2	Y2H Array	32296183
Intra	RAB27B	O00194	SYTL5	Homo sapiens	Q8TDW5	Anti Tag CoIP	28514442
Intra	RAB27B	O00194	SYTL5	Homo sapiens	Q8TDW5	Anti Tag CoIP	33961781
Intra	RAB27B	O00194	SYTL5	Homo sapiens	Q8TDW5	Y2H Array	31515488
Intra	RAB27B	O00194	CAV1	Homo sapiens	Q03135	Anti Bait CoIP	19706440
Intra	RAB27B	O00194	CAV1	Homo sapiens	Q03135	Anti Tag CoIP	19706440
Intra	RAB27B	O00194	MLPH	Homo sapiens	Q9BV36	Anti Tag CoIP	33961781
Intra	RAB27B	O00194	MLPH	Homo sapiens	Q9BV36	Validated Y2H	32296183
Intra	RAB27B	O00194	MLPH	Homo sapiens	Q9BV36	Y2H Prey Pooling	32296183
Intra	RAB27B	O00194	MLPH	Homo sapiens	Q9BV36	Y2H Array	32296183
Intra	RAB27B	O00194	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	RAB27B	O00194	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	RAB27B	O00194	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	RAB27B	O00194	DHPS	Homo sapiens	P49366	Y2H Array	32296183
Intra	RAB27B	O00194	DHPS	Homo sapiens	P49366	Y2H Prey Pooling	25416956
Intra	RAB27B	O00194	DHPS	Homo sapiens	P49366	Y2H Prey Pooling	32296183
Intra	RAB27B	O00194	DHPS	Homo sapiens	P49366	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RAB27B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75994	RAB27B Protein, Human (HEK293)	O00194 (T2-K215)	≥95%
HY-P75995	RAB27B Protein, Human (HEK293, His)	O00194 (T2-K215)	≥95%
HY-P75996	RAB27B Protein, Human (HEK293, Fc)	O00194 (T2-K215)	≥95%

Related Diseases

Diseases

Alias

Griscelli Syndrome

Chediak-Higashi-Like Syndrome	Griscelli-Prunieras Syndrome
Partial Albinism-Immunodeficiency Syndrome	Griscelli Disease
Gs	Hypopigmentation Immunodeficiency Disease
Partial Albinism With Immunodeficiency	Immunodeficiency Syndrome With Hypopigmentation
Hypopigmentation-Immunodeficiency Disease

Piebald Trait

Piebaldism	PBT
Partial Albinism	Albinoidism, Oculocutaneous, Autosomal Dominant

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11538	RAB27B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RAB27B	MGD	MGI:1931295
Rattus norvegicus	RAB27B	RGD	RGD:620114
Felis catus	RAB27B	VGNC	VGNC:80473
Bos taurus	RAB27B	VGNC	VGNC:33634
Canis familiaris	RAB27B	VGNC	VGNC:45268
Macaca mulatta	RAB27B	VGNC	VGNC:104238
Others	RAB27B	NCBI

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