RAB5C - RAB5C, member RAS oncogene family Gene

Homo sapiens

Also known as RABL; L1880; RAB5L; RAB5CL

Gene ID: 5878 | Gene type: protein coding

About RAB5C

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,124,979-42,154,989 (from NCBI)

This gene has 9 transcripts (splice variants), 274 orthologues and 68 paralogues. Ubiquitous expression in kidney (RPKM 55.2), bone marrow (RPKM 47.2) and 25 other tissues.

Summary

Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]

RAB5C Products(3)

mRNA	Protein	Name
NM_001252039.2	NP_001238968.1	ras-related protein Rab-5C isoform b
NM_004583.4	NP_004574.2	ras-related protein Rab-5C isoform a
NM_201434.3	NP_958842.1	ras-related protein Rab-5C isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	17562788	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17562788	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in plasma membrane to endosome transport	IMP IMP: Inferred from mutant phenotype	17562788	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in lipid droplet	IDA IDA: Inferred from direct assay	14741744	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB5C Protein Structure

Ras

0
100
200
216 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-5C

RAB5C, member of RAS oncogene family

Related Diseases

Diseases

Alias

Argentine Hemorrhagic Fever

Argentinian Hemorrhagic Fever	Junin Hemorrhagic Fever
Hemorrhagic Fever, Argentinian	Ahf - [Argentinian Haemorrhagic Fever]
Argentine Haemorrhagic Fever	Junin Haemorrhagic Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11573	RAB5C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RAB5C	VGNC	VGNC:99428
Rattus norvegicus	RAB5C	RGD	RGD:1307095
Canis familiaris	RAB5C	VGNC	VGNC:55798
Bos taurus	RAB5C	VGNC	VGNC:50253
Mus musculus	RAB5C	MGD	MGI:105306
Others	RAB5C	NCBI

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