2. Gene
  3. NTN4 - netrin 4 Gene

NTN4 - netrin 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PRO3091

Gene ID: 59277 | Gene type: protein coding

About NTN4

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:95,657,807-95,791,155 (from NCBI)

This gene has 8 transcripts (splice variants), 248 orthologues and 27 paralogues. Broad expression in spleen (RPKM 88.7), kidney (RPKM 62.7) and 20 other tissues.

Summary

This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

NTN4 Products(4)

mRNA Protein Name
NM_001329700.2 NP_001316629.1 netrin-4 isoform 2 precursor
NM_001329701.2 NP_001316630.1 netrin-4 isoform 3
NM_001329702.2 NP_001316631.1 netrin-4 isoform 3
NM_021229.4 NP_067052.2 netrin-4 isoform 1 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTN4 Protein Structure

Laminin_N

Laminin_N: Laminin N-terminal (Domain VI) (34 - 260)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (262 - 318)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (332 - 383)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (395 - 443)

NTR

NTR: UNC-6/NTR/C345C module (518 - 621)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 628 a.a.
Protein Preferred Names Protein Names

netrin-4

beta-netrin

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09623 NTN4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NTN4 VGNC VGNC:63904
Rattus norvegicus NTN4 RGD RGD:1565947
Canis familiaris NTN4 VGNC VGNC:44009
Bos taurus NTN4 VGNC VGNC:32306
Macaca mulatta NTN4 VGNC VGNC:75399
Mus musculus NTN4 MGD MGI:1888978
Others NTN4 NCBI