NTN4 - netrin 4 Gene

Homo sapiens

Also known as PRO3091

Gene ID: 59277 | Gene type: protein coding

About NTN4

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:95,657,807-95,791,155 (from NCBI)

This gene has 8 transcripts (splice variants), 248 orthologues and 27 paralogues. Broad expression in spleen (RPKM 88.7), kidney (RPKM 62.7) and 20 other tissues.

Summary

This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

NTN4 Products(4)

mRNA	Protein	Name
NM_001329700.2	NP_001316629.1	netrin-4 isoform 2 precursor
NM_001329701.2	NP_001316630.1	netrin-4 isoform 3
NM_001329702.2	NP_001316631.1	netrin-4 isoform 3
NM_021229.4	NP_067052.2	netrin-4 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTN4 Protein Structure

Laminin_N

Laminin_EGF

NTR

0
100
200
300
400
500
628 a.a.

Protein Preferred Names

Protein Names

netrin-4

beta-netrin

NTN4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NTN4	Q9HB63	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	NTN4	Q9HB63	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	NTN4	Q9HB63	KPRP	Homo sapiens	Q5T749	Y2H Prey Pooling	32296183
Intra	NTN4	Q9HB63	KPRP	Homo sapiens	Q5T749	Y2H Array	32296183
Intra	NTN4	Q9HB63	CASK	Homo sapiens	O14936-4	Y2H Array	32296183
Intra	NTN4	Q9HB63	CASK	Homo sapiens	O14936-4	Y2H Prey Pooling	32296183
Intra	NTN4	Q9HB63	LCE1C	Homo sapiens	Q5T751	Y2H Array	32296183
Intra	NTN4	Q9HB63	LCE1C	Homo sapiens	Q5T751	Y2H Prey Pooling	32296183
Intra	NTN4	Q9HB63	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	NTN4	Q9HB63	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	NTN4	Q9HB63	KRTAP21-2	Homo sapiens	Q3LI59	Y2H Array	32296183
Intra	NTN4	Q9HB63	KRTAP21-2	Homo sapiens	Q3LI59	Y2H Prey Pooling	32296183
Intra	NTN4	Q9HB63	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	NTN4	Q9HB63	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	NTN4	Q9HB63	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	NTN4	Q9HB63	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	NTN4	Q9HB63	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	NTN4	Q9HB63	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	NTN4	Q9HB63	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	NTN4	Q9HB63	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	NTN4	Q9HB63	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	NTN4	Q9HB63	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	NTN4	Q9HB63	HOXA1	Homo sapiens	P49639	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09623	NTN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NTN4	VGNC	VGNC:63904
Rattus norvegicus	NTN4	RGD	RGD:1565947
Canis familiaris	NTN4	VGNC	VGNC:44009
Bos taurus	NTN4	VGNC	VGNC:32306
Macaca mulatta	NTN4	VGNC	VGNC:75399
Mus musculus	NTN4	MGD	MGI:1888978
Others	NTN4	NCBI

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