2. Gene
  3. RBBP5 - RB binding protein 5, histone lysine methyltransferase complex subunit Gene

RBBP5 - RB binding protein 5, histone lysine methyltransferase complex subunit Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RBQ3; SWD1

Gene ID: 5929 | Gene type: protein coding

About RBBP5

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,086,142-205,121,978 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 6.5), lymph node (RPKM 6.0) and 25 other tissues.

Summary

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]

RBBP5 Products(3)

mRNA Protein Name
NM_001193272.2 NP_001180201.1 retinoblastoma-binding protein 5 isoform 2
NM_001193273.2 NP_001180202.1 retinoblastoma-binding protein 5 isoform 3
NM_005057.4 NP_005048.2 retinoblastoma-binding protein 5 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables histone binding IDA
IDA: Inferred from direct assay
15960975 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12482968 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
16603732 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
17500065 GOA
involved in response to estrogen IDA
IDA: Inferred from direct assay
16603732 GOA
involved in transcription initiation-coupled chromatin remodeling IDA
IDA: Inferred from direct assay
19556245 GOA
Cellular Component GO Annotation Evidence Reference Source
part of MLL1 complex IDA
IDA: Inferred from direct assay
15960975 GOA
part of MLL1 complex IPI
IPI: Inferred from physical interaction
23508102 GOA
part of MLL1/2 complex IPI
IPI: Inferred from physical interaction
23508102 GOA
part of MLL3/4 complex IDA
IDA: Inferred from direct assay
17500065 GOA
part of MLL3/4 complex IPI
IPI: Inferred from physical interaction
23508102 GOA
part of Set1C/COMPASS complex IDA
IDA: Inferred from direct assay
17998332 GOA
part of Set1C/COMPASS complex IPI
IPI: Inferred from physical interaction
23508102 GOA
part of histone methyltransferase complex IDA
IDA: Inferred from direct assay
17355966 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15199122 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBBP5 Protein Structure

WD40

WD40: WD domain, G-beta repeat (30 - 52)

WD40

WD40: WD domain, G-beta repeat (61 - 94)

  • 0
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  • 400
  • 500
  • 538 a.a.
Protein Preferred Names Protein Names

retinoblastoma-binding protein 5

RBBP-5

RBBP5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RBBP5 Q15291 SETD1A Homo sapiens O15047
Anti Tag CoIP
33961781
Intra
RBBP5 Q15291 ASH2L Homo sapiens Q9UBL3
Anti Bait CoIP
16603732
Intra
RBBP5 Q15291 ASH2L Homo sapiens Q9UBL3
Anti Bait CoIP
17500065
Intra
RBBP5 Q15291 ASH2L Homo sapiens Q9UBL3
Anti Bait CoIP
17178841
Intra
RBBP5 Q15291 WDR5 Homo sapiens P61964
Anti Bait CoIP
17041588
Intra
RBBP5 Q15291 WDR5 Homo sapiens P61964
ITC
21220120
Intra
RBBP5 Q15291 WDR5 Homo sapiens P61964
Anti Bait CoIP
17500065
Intra
RBBP5 Q15291 WDR5 Homo sapiens P61964
Anti Bait CoIP
17178841
Intra
RBBP5 Q15291 WDR5 Homo sapiens P61964
Anti Bait CoIP
17925232
Intra
RBBP5 Q15291 WDR5 Homo sapiens P61964
Pull Down
17500065
Intra
RBBP5 Q15291 WDR5 Homo sapiens P61964
Pull Down
21220120
Intra
RBBP5 Q15291 KMT2A Homo sapiens Q03164
Pull Down
15960975
Intra
RBBP5 Q15291 KMT2A Homo sapiens Q03164
Anti Tag CoIP
15960975
Intra
RBBP5 Q15291 KMT2A Homo sapiens Q03164
Anti Tag CoIP
33961781
Intra
RBBP5 Q15291 PAXIP1 Homo sapiens Q6ZW49
Anti Bait CoIP
17500065
Intra
RBBP5 Q15291 PAXIP1 Homo sapiens Q6ZW49
Anti Bait CoIP
17925232
Intra
RBBP5 Q15291 PAXIP1 Homo sapiens Q6ZW49
Anti Bait CoIP
17178841
Intra
RBBP5 Q15291 PAXIP1 Homo sapiens Q6ZW49
Anti Tag CoIP
33961781
Intra
RBBP5 Q15291 CXXC1 Homo sapiens Q9P0U4
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Kabuki Syndrome 1

Kabuki Syndrome

Niikawa-Kuroki Syndrome

Kabuki Make-Up Syndrome

Kms

KABUK1

Kabuki Make Up Syndrome

Nks

Kabuki Makeup Syndrome

Kabuki Syndrome, Type 1
Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1

MEN1

Wermer Syndrome

Multiple Endocrine Neoplasia 1

Multiple Endocrine Neoplasia, Type 1

Men I

Endocrine Adenomatosis, Multiple

Mea I

Men Type I

Wermer'S Syndrome

Men1 Syndrome

Multiple Endocrine Adenomatosis

Endocrine Adenomatosis Multiple

Men 1

Familial Multiple Endocrine Neoplasia Type I

Neoplasia, Endocrine, Multiple, Type 1

Multiple Endocrine Neoplasia
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11717 RBBP5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RBBP5 RGD RGD:1305532
Mus musculus RBBP5 MGD MGI:1918367
Felis catus RBBP5 VGNC VGNC:69257
Macaca mulatta RBBP5 VGNC VGNC:76676
Canis familiaris RBBP5 VGNC VGNC:53127
Bos taurus RBBP5 VGNC VGNC:50641
Others RBBP5 NCBI