ABCE1 - ATP binding cassette subfamily E member 1 Gene

Homo sapiens

Also known as RLI; OABP; RLI1; ABC38; RNS4I; RNASEL1; RNASELI

Gene ID: 6059 | Gene type: protein coding

About ABCE1

Cytogenetic location: 4q31.21 Genomic coordinates (GRCh38): 4:145,098,311-145,129,524 (from NCBI)

This gene has 10 transcripts (splice variants) and 227 orthologues. Ubiquitous expression in appendix (RPKM 18.4), lymph node (RPKM 18.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ABCE1 Products(2)

mRNA	Protein	Name
NM_001040876.2	NP_001035809.1	ATP-binding cassette sub-family E member 1
NM_002940.3	NP_002931.2	ATP-binding cassette sub-family E member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	20122402	GOA
enables CTPase activity	IDA IDA: Inferred from direct assay	20122402	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	20122402	GOA
enables endoribonuclease inhibitor activity	IDA IDA: Inferred from direct assay	7539425	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7539425	GOA
enables ribonucleoside triphosphate phosphatase activity	IDA IDA: Inferred from direct assay	20122402	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of endoribonuclease activity	IDA IDA: Inferred from direct assay	7539425	GOA
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	21448132	GOA
involved in ribosome disassembly	IDA IDA: Inferred from direct assay	20122402	GOA
involved in translational termination	IDA IDA: Inferred from direct assay	20122402	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11585831	GOA
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	20122402	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	11585831	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABCE1 Protein Structure

RLI

Fer4

ABC_tran

0
100
200
300
400
500
599 a.a.

Protein Preferred Names

Protein Names

ATP-binding cassette sub-family E member 1

2'-5'-oligoadenylate-binding protein

ABCE1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ABCE1	P61221	EIF3J	Homo sapiens	O75822	Y2H Array	32296183
Intra	ABCE1	P61221	EIF3J	Homo sapiens	O75822	Y2H Prey Pooling	32296183
Intra	ABCE1	P61221	EIF3J	Homo sapiens	O75822	Anti Tag CoIP	35271311
Cross	ABCE1	P61221	gag	Human immunodeficiency virus	P03347-1	Pull Down	16275648
Cross	ABCE1	P61221	gag	Human immunodeficiency virus	P03347-1	Anti Tag CoIP	16275648

Cross: Cross-species interaction Intra: Intraspecies interaction

ABCE1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81954	ABCE1 Antibody (YA1699)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00072	ABCE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ABCE1	VGNC	VGNC:69581
Canis familiaris	ABCE1	VGNC	VGNC:37449
Bos taurus	ABCE1	VGNC	VGNC:25479
Mus musculus	ABCE1	MGD	MGI:1195458
Felis catus	ABCE1	VGNC	VGNC:68188
Rattus norvegicus	ABCE1	RGD	RGD:1305301

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