EIF3J - eukaryotic translation initiation factor 3 subunit J Gene

Homo sapiens

Also known as EIF3S1; eIF3-p35; eIF3-alpha

Gene ID: 8669 | Gene type: protein coding

About EIF3J

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:44,537,147-44,562,803 (from NCBI)

This gene has 7 transcripts (splice variants) and 248 orthologues. Ubiquitous expression in appendix (RPKM 31.0), brain (RPKM 29.6) and 25 other tissues.

Summary

This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

EIF3J Products(3)

mRNA	Protein	Name
NM_001284335.2	NP_001271264.1	eukaryotic translation initiation factor 3 subunit J isoform 2
NM_001284336.2	NP_001271265.1	eukaryotic translation initiation factor 3 subunit J isoform 3
NM_003758.4	NP_003749.2	eukaryotic translation initiation factor 3 subunit J isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14688252	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3J Protein Structure

eIF3_subunit

0
100
200
258 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit J

eukaryotic translation initiation factor 3, subunit 1 (alpha, 35kD)

EIF3J Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF3J	O75822	ABCE1	Homo sapiens	P61221	Validated Y2H	32296183
Intra	EIF3J	O75822	EIF3A	Homo sapiens	Q14152	Pull Down	23623729
Intra	EIF3J	O75822	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	14688252
Intra	EIF3J	O75822	EIF4G1	Homo sapiens	Q04637	Pull Down	16932749
Intra	EIF3J	O75822	EIF4G1	Homo sapiens	Q04637	Anti Tag CoIP	16932749

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04266	EIF3J Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EIF3J	VGNC	VGNC:80979
Mus musculus	EIF3J	MGD	MGI:1925905
Canis familiaris	EIF3J	VGNC	VGNC:40276
Bos taurus	EIF3J	VGNC	VGNC:28400
Macaca mulatta	EIF3J	VGNC	VGNC:72188
Rattus norvegicus	EIF3J	RGD	RGD:1593338

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