RPS7 - ribosomal protein S7 Gene

Homo sapiens

Also known as S7; eS7; DBA8

Gene ID: 6201 | Gene type: protein coding

About RPS7

Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:3,575,260-3,580,920 (from NCBI)

This gene has 12 transcripts (splice variants), 228 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 822.9), bone marrow (RPKM 559.6) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS7 Products(1)

mRNA	Protein	Name
NM_001011.4	NP_001002.1	40S ribosomal protein S7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	16213212	GOA
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	16213212	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9687515	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20873783	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	18697920	GOA
enables ubiquitin ligase inhibitor activity	IDA IDA: Inferred from direct assay	17310983	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	17310983	GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	17310983	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17310983	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17310983	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	17310983	GOA
involved in rRNA processing	IMP IMP: Inferred from mutant phenotype	18697920	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA
involved in ribosomal small subunit biogenesis	IMP IMP: Inferred from mutant phenotype	18697920	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with centrosome	IDA IDA: Inferred from direct assay	20873783	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	11823430	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9687515	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20873783	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	17310983	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	18809582	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS7 Protein Structure

Ribosomal_S7e

0
100
194 a.a.

Protein Preferred Names

Protein Names

40S ribosomal protein S7

small ribosomal subunit protein eS7

Recombinant RPS7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71266	RPS7 Protein, Human (His)	P62081 (M1-L194)	≥95%

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia 8

DBA8	Rps7-Related Diamond-Blackfan Anemia
Anemia, Diamond-Blackfan, Type 8

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Macrocytic Anemia

Anemia Macrocytic	Anemia, Macrocytic
Macrocytic Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12269	RPS7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPS7	MGD	MGI:1333818
Canis familiaris	RPS7	VGNC	VGNC:45748
Bos taurus	RPS7	VGNC	VGNC:34150
Macaca mulatta	RPS7	VGNC	VGNC:106214
Rattus norvegicus	RPS7	RGD	RGD:61907
Others	RPS7	NCBI

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