SAFB - scaffold attachment factor B Gene

Homo sapiens

Also known as HAP; HET; SAF-B; SAFB1; SAB-B1; SAF-B1

Gene ID: 6294 | Gene type: protein coding

About SAFB

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,623,083-5,668,478 (from NCBI)

This gene has 14 transcripts (splice variants), 235 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 29.9), testis (RPKM 26.5) and 25 other tissues.

Summary

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an Estrogen Receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

SAFB Products(6)

mRNA	Protein	Name
NM_001201338.2	NP_001188267.1	scaffold attachment factor B1 isoform 1
NM_001201339.2	NP_001188268.1	scaffold attachment factor B1 isoform 2
NM_001201340.2	NP_001188269.1	scaffold attachment factor B1 isoform 4
NM_001320571.2	NP_001307500.1	scaffold attachment factor B1 isoform 5
NM_001320572.2	NP_001307501.1	scaffold attachment factor B1 isoform 6
NM_002967.4	NP_002958.2	scaffold attachment factor B1 isoform 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12660241	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	22693546	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAFB Protein Structure

SAP

0
200
400
600
800
915 a.a.

Protein Preferred Names

Protein Names

scaffold attachment factor B1

HSP27 ERE-TATA-binding protein

SAFB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SAFB	Q15424	SAFB2	Homo sapiens	Q14151	Anti Tag CoIP	12660241
Intra	SAFB	Q15424	SAFB2	Homo sapiens	Q14151	Y2H	12660241
Intra	SAFB	Q15424	TP53	Homo sapiens	P04637	Anti Bait CoIP	21130767
Intra	SAFB	Q15424	TP53	Homo sapiens	P04637	IF	21130767
Intra	SAFB	Q15424	SRPK1	Homo sapiens	Q96SB4-2	Anti Tag CoIP	19674106
Intra	SAFB	Q15424	SRPK1	Homo sapiens	Q96SB4-2	Pull Down	19674106

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Denys-Drash Syndrome

Drash Syndrome	DDS
Nephropathy, Wilms Tumor, And Genital Anomalies	Wilms Tumor And Pseudohermaphroditism
Wilms Tumor And Pseudo- Or True Hermaphroditism	Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor
Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor	Wilms Tumor-Dsd Syndrome
Wilms Tumor-Disorder Of Sex Development Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12413	SAFB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12414	SAFB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SAFB	VGNC	VGNC:76964
Felis catus	SAFB	VGNC	VGNC:64854
Canis familiaris	SAFB	VGNC	VGNC:45844
Rattus norvegicus	SAFB	RGD	RGD:620613
Mus musculus	SAFB	MGD	MGI:2146974

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