CX3CL1 - C-X3-C motif chemokine ligand 1 Gene

Homo sapiens

Also known as NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin

Gene ID: 6376 | Gene type: protein coding

About CX3CL1

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,372,490-57,385,044 (from NCBI)

This gene has 4 transcripts (splice variants), 155 orthologues and 25 paralogues. Broad expression in brain (RPKM 40.1), lung (RPKM 37.8) and 21 other tissues.

Summary

This gene belongs to the CX3C subgroup of chemokines, characterized by the number of Amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three Amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif Chemokine Receptor 1 gene product. This gene plays a role in a wide range of diseases, including Cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections. [provided by RefSeq, Sep 2017]

CX3CL1 Products(2)

mRNA	Protein	Name
NM_001304392.3	NP_001291321.1	fractalkine isoform 2
NM_002996.6	NP_002987.1	fractalkine isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CX3C chemokine receptor binding	IDA IDA: Inferred from direct assay	10415068	GOA
enables CXCR1 chemokine receptor binding	IPI IPI: Inferred from physical interaction	10187784	GOA
enables chemoattractant activity	IMP IMP: Inferred from mutant phenotype	10899174	GOA
enables chemokine activity	IDA IDA: Inferred from direct assay	21829356	GOA
enables chemokine activity	IGI IGI: Inferred from genetic interaction	10415068	GOA
enables integrin binding	IDA IDA: Inferred from direct assay	23125415	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9931005	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell adhesion	IPI IPI: Inferred from physical interaction	10187784	GOA
involved in cell chemotaxis	IDA IDA: Inferred from direct assay	10415068	GOA
involved in chemokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	10415068	GOA
involved in chemokine-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	10869418	GOA
involved in chemotaxis	IDA IDA: Inferred from direct assay	21829356	GOA
involved in chemotaxis	IMP IMP: Inferred from mutant phenotype	23125415	GOA
involved in integrin activation	IMP IMP: Inferred from mutant phenotype	23125415	GOA
involved in leukocyte migration involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	23125415	GOA
involved in microglial cell proliferation	IMP IMP: Inferred from mutant phenotype	12125082	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	24294368	GOA
involved in negative regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	10869418	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	25435433	GOA
involved in negative regulation of hippocampal neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10869418	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	10652441	GOA
involved in positive chemotaxis	IMP IMP: Inferred from mutant phenotype	10899174	GOA
involved in positive regulation of I-kappaB phosphorylation	IGI IGI: Inferred from genetic interaction	10869418	GOA
involved in positive regulation of MAPK cascade	IGI IGI: Inferred from genetic interaction	10415068	GOA
involved in positive regulation of actin filament bundle assembly	IGI IGI: Inferred from genetic interaction	10415068	GOA
involved in positive regulation of calcium-independent cell-cell adhesion	IDA IDA: Inferred from direct assay	12714508	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	10869418	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	24294368	GOA
involved in positive regulation of inflammatory response	IEP IEP: Inferred from expression pattern	11777952	GOA
involved in positive regulation of microglial cell migration	IDA IDA: Inferred from direct assay	10415068	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	10415068	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IGI IGI: Inferred from genetic interaction	10415068	GOA
involved in regulation of lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	10652441	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	12714508	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	10415068	GOA
located in extracellular region	IMP IMP: Inferred from mutant phenotype	10899174	GOA
located in membrane	IDA IDA: Inferred from direct assay	10899174	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CX3CL1 Protein Structure

IL8

0
100
200
300
397 a.a.

Protein Preferred Names

Protein Names

fractalkine

C-X3-C motif chemokine 1

CX3CL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CX3CL1	P78423	ITGB3	Homo sapiens	P05106	ELISA	24789099
Intra	CX3CL1	P78423	ITGB3	Homo sapiens	P05106	ELISA	23125415
Intra	CX3CL1	P78423	ITGB3	Homo sapiens	P05106	Pull Down	24789099

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CX3CL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7180	Fractalkine/CX3CL1 Protein, Human	P78423 (Q25-G100)	≥95%
HY-P7355	Fractalkine/CX3CL1 Protein, Human (S199N, CHO)	P78423 (Q25-R339, S199N)	≥95%
HY-P72685	Fractalkine/CX3CL1 Protein, Human (315a.a, HEK293, His)	P78423 (Q25-R339)	≥95%
HY-P76938	Fractalkine/CX3CL1 Protein, Cynomolgus (HEK293, Fc)	EHH60415.1 (Q25-G100)	≥95%
HY-P76939	Fractalkine/CX3CL1 Protein, Cynomolgus (HEK293, His)	EHH60415.1 (Q25-G100)	≥95%
HY-P78937	Fractalkine/CX3CL1 Protein, Human (Biotinylated, HEK293, His)	P78423/AAH01163 (Q25-Q341)	≥95%

Related Diseases

Diseases

Alias

Pityriasis Rosea

Pityriasis Circinata

Gibert Pityriasis

Vasculitis

Angiitis	Autoimmune Vasculitis
Systemic Vasculitis	Vasculitis, Autoimmune

Chorioretinitis

Retinochoroiditis

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Neuritis

Peripheral Neuritis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Chronic Cholangitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Retinal Degeneration

Degeneration Of Retina

Refractory Plasma Cell Neoplasm

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease	Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Plosl	Nhd
Presenile Dementia With Bone Cysts	Plo-Sl
PLOSL1	Dementia, Prefrontal, With Bone Cysts
Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease
Progressive Dementia With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03378	CX3CL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99404	Quetmolimab	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CX3CL1	VGNC	VGNC:61296
Mus musculus	CX3CL1	MGD	MGI:1097153
Rattus norvegicus	CX3CL1	RGD	RGD:620458
Canis familiaris	CX3CL1	VGNC	VGNC:39745
Bos taurus	CX3CL1	VGNC	VGNC:52190
Macaca mulatta	CX3CL1	VGNC	VGNC:71395
Macaca fascicularis	CX3CL1	NCBI	NCBI:102117496
Others	CX3CL1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.