SDC4 - syndecan 4 Gene

Homo sapiens

Also known as SYND4

Gene ID: 6385 | Gene type: protein coding

About SDC4

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,325,288-45,348,424 (from NCBI)

This gene has 1 transcript (splice variant), 197 orthologues, 3 paralogues and is associated with 48 phenotypes. Broad expression in liver (RPKM 189.5), lung (RPKM 100.6) and 23 other tissues.

Summary

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

SDC4 Products(1)

mRNA	Protein	Name
NM_002999.4	NP_002990.2	syndecan-4 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18093920	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12571249	GOA
enables thrombospondin receptor activity	IMP IMP: Inferred from mutant phenotype	17879962	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	19350579	GOA
involved in positive regulation of exosomal secretion	IMP IMP: Inferred from mutant phenotype	22660413	GOA
involved in positive regulation of extracellular exosome assembly	IMP IMP: Inferred from mutant phenotype	22660413	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDC4 Protein Structure

Syndecan

0
100
198 a.a.

Protein Preferred Names

Protein Names

syndecan-4

amphiglycan

SDC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SDC4	P31431	SDC2	Homo sapiens	P34741	Comigration in Gel	18093920
Intra	SDC4	P31431	PRKCA	Homo sapiens	P17252	Pull Down	12571249
Intra	SDC4	P31431	SDC3	Homo sapiens	O75056	Comigration in Gel	18093920
Intra	SDC4	P31431	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	SDC4	P31431	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	25416956
Intra	SDC4	P31431	SGTA	Homo sapiens	O43765	Validated Y2H	25416956
Intra	SDC4	P31431	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	SDC4	P31431	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	SDC4	P31431	SGTA	Homo sapiens	O43765	Y2H Array	25416956
Intra	SDC4	P31431	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	SDC4	P31431	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	SDC4	P31431	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	SDC4	P31431	IL7R	Homo sapiens	P16871	Y2H Prey Pooling	32296183
Intra	SDC4	P31431	IL7R	Homo sapiens	P16871	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SDC4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73623	Syndecan-4 Protein, Human (HEK293, His)	P31431-1 (E19-E145)	≥95%

Related Diseases

Diseases

Alias

Thyroid Carcinoma

Thyroid Cancer	Malignant Neoplasm Of Thyroid
Thyroid Neoplasm

Achromatopsia 7

ACHM7

Achromatopsia, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159147	SIAIS039		/	Unkown
HY-RS12582	SDC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SDC4	VGNC	VGNC:98441
Canis familiaris	SDC4	VGNC	VGNC:45944
Mus musculus	SDC4	MGD	MGI:1349164
Rattus norvegicus	SDC4	RGD	RGD:3650
Bos taurus	SDC4	VGNC	VGNC:34381
Felis catus	SDC4	VGNC	VGNC:64946
Others	SDC4	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.