CLSPN - claspin Gene

Homo sapiens

Gene ID: 63967 | Gene type: protein coding

About CLSPN

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,720,213-35,769,978 (from NCBI)

This gene has 6 transcripts (splice variants) and 211 orthologues. Broad expression in bone marrow (RPKM 2.6), testis (RPKM 2.4) and 16 other tissues.

Summary

The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

CLSPN Products(3)

mRNA	Protein	Name
NM_001190481.2	NP_001177410.1	claspin isoform 2
NM_001330490.2	NP_001317419.1	claspin isoform 3
NM_022111.4	NP_071394.2	claspin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA secondary structure binding	IDA IDA: Inferred from direct assay	5226314	GOA
enables anaphase-promoting complex binding	IPI IPI: Inferred from physical interaction	18662541	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16885022	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	16963448	GOA
acts upstream of DNA replication checkpoint signaling	IDA IDA: Inferred from direct assay	16123041	GOA
acts upstream of or within DNA replication checkpoint signaling	IDA IDA: Inferred from direct assay	12766152	GOA
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	16885022	GOA
involved in mitotic DNA replication checkpoint signaling	IMP IMP: Inferred from mutant phenotype	16885022	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IDA IDA: Inferred from direct assay	18662541	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	16885022	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12766152	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

claspin

claspin homolog

CLSPN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CLSPN	Q9HAW4	CDC45	Homo sapiens	O75419	Pull Down	23910567
Intra	CLSPN	Q9HAW4	CHEK1	Homo sapiens	O14757	Protein Kinase Assay	16963448
Intra	CLSPN	Q9HAW4	CHEK1	Homo sapiens	O14757	Pull Down	16963448
Intra	CLSPN	Q9HAW4	CHEK1	Homo sapiens	O14757	Anti Tag CoIP	16963448

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ataxia-Telangiectasia

Ataxia Telangiectasia	Louis-Bar Syndrome
AT	At1
Ataxia-Telangiectasia Syndrome	Ataxia - Telangiectasia Variant
Boder-Sedgwick Syndrome	Louis Bar Syndrome
Cerebello-Oculocutaneous Telangiectasia	Immunodeficiency With Ataxia Telangiectasia
A-T	Ataxia Telangiectasia Syndrome
Atm	Telangiectasia, Cerebello-Oculocutaneous
Ataxia-Telangiectasia Variant

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02839	CLSPN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CLSPN	RGD	RGD:1309083
Macaca mulatta	CLSPN	VGNC	VGNC:99869
Bos taurus	CLSPN	VGNC	VGNC:27465
Canis familiaris	CLSPN	VGNC	VGNC:39362
Felis catus	CLSPN	VGNC	VGNC:60978
Mus musculus	CLSPN	MGD	MGI:2445153

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