2. Gene
  3. SELPLG - selectin P ligand Gene

SELPLG - selectin P ligand Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CLA; CD162; PSGL1; PSGL-1

Gene ID: 6404 | Gene type: protein coding

About SELPLG

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,621,895-108,633,894 (from NCBI)

This gene has 3 transcripts (splice variants) and 72 orthologues. Broad expression in spleen (RPKM 29.0), lymph node (RPKM 26.4) and 22 other tissues.

Summary

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- Selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

SELPLG Products(2)

mRNA Protein Name
NM_001206609.2 NP_001193538.1 P-selectin glycoprotein ligand 1 isoform 1 precursor
NM_003006.4 NP_002997.2 P-selectin glycoprotein ligand 1 isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11081633 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to interleukin-6 IDA
IDA: Inferred from direct assay
9486531 GOA
involved in leukocyte migration IDA
IDA: Inferred from direct assay
25425738 GOA
involved in leukocyte tethering or rolling IDA
IDA: Inferred from direct assay
25425738 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
21696602 GOA
located in plasma membrane raft IDA
IDA: Inferred from direct assay
25425738 GOA
located in uropod IDA
IDA: Inferred from direct assay
21696602 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

P-selectin glycoprotein ligand 1

cutaneous lymphocyte-associated associated antigen

SELPLG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SELPLG Q14242 SELP Homo sapiens P16109
SPR
19118202
Intra
SELPLG Q14242 SNX20 Homo sapiens Q7Z614
Peptide Array
18196517
Intra
SELPLG Q14242 SNX20 Homo sapiens Q7Z614
Y2H
18196517
Intra
SELPLG Q14242 SNX20 Homo sapiens Q7Z614
Anti Bait CoIP
18196517
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SELPLG Proteins

Cat. No. Product Name Accession Purity
HY-P72485 CD162/PSGL-1 Protein, Human (HEK293, hFc) Q14242 (Q42-G295) ≥95%
HY-P77162 CD162/PSGL-1 Protein, Human (HEK293, His-Fc) AAC50061.1(L18-V295) ≥95%
HY-P77163 CD162/PSGL-1 Protein, Human (HEK293, His) Q14242 (M1-G295) ≥95%
HY-P77164 CD162/PSGL-1 Protein, Human (HEK293, mFc) AAC50061.1(L18-V295) ≥95%

Related Diseases

Diseases Alias
Human Granulocytic Anaplasmosis

Human Granulocytic Ehrlichiosis

Hge

Human Ehrlichial Infection, Human Granulocytic Type

Human Anaplasmosis Due To Anaplasma Phagocytophilum
Ehrlichiosis

Human Ehrlichiosis

He

Hey
Thrombosis

Thrombosis Of Blood Vessel
Cerebrovascular Disease

Cerebrovascular Disorder

Cerebrovascular Accident

Cerebrovascular Disorders

Cva

Stroke
Endocervicitis
Leukocyte Adhesion Deficiency, Type I

Leukocyte Adhesion Deficiency

Leukocyte Adhesion Deficiency 1

LAD1

Lad

Lymphocyte Function-Associated Antigen 1 Immunodeficiency

Leukocyte Adhesion Deficiency Type I

Leukocyte Adhesion Deficiency Type 1

Linear Iga Bullous Dermatosis

Linear Iga Dermatosis

Leukocyte-Adhesion Deficiency Syndrome

Lfa1 Immunodeficiency

Congenital Leukocyte Adherence Deficiency

Lad-I

Linear Iga Disease

Leukocyte Adhesion Deficiency Syndrome

Lad 1

Lfa 1 Immunodeficiency

Linear Immunoglobulin A Dermatosis

Leucocyte Adhesion Deficiency Type 1

Leukocyte Adhesion Molecule Deficiency Type 1
Colon Carcinoma In Situ

Carcinoma In Situ Of Colon

Stage 0 Colonic Carcinoma

Stage 0 Carcinoma Of Colon

Intraepithelial Neoplasia Of Colon, High Grade

Carcinoma In Situ Of Cecum

Carcinoma In Situ Of Hepatic Flexure

Carcinoma In Situ Of Ileocecal Valve

Carcinoma In Situ Of Hepatic Flexure Of Colon
Intestine Carcinoma In Situ
Acute Flaccid Myelitis
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Aseptic Meningitis

Acute Aseptic Meningitis

Meningitis Aseptic

Meningitis, Aseptic
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12648 SELPLG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SELPLG VGNC VGNC:107723
Macaca mulatta SELPLG VGNC VGNC:77158
Rattus norvegicus SELPLG RGD RGD:1307971
Mus musculus SELPLG MGD MGI:106689
Canis familiaris SELPLG VGNC VGNC:45986
Bos taurus SELPLG VGNC VGNC:34425
Macaca fascicularis SELPLG NCBI NCBI:102142477
Others SELPLG NCBI