RBKS - ribokinase Gene

Homo sapiens

Also known as RK; RBSK

Gene ID: 64080 | Gene type: protein coding

About RBKS

Cytogenetic location: 2p23.2 Genomic coordinates (GRCh38): 2:27,781,379-27,890,387 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues and 3 paralogues. Broad expression in adrenal (RPKM 7.1), small intestine (RPKM 6.5) and 22 other tissues.

Summary

This gene encodes a member of the carbohydrate kinase PfkB family. The encoded protein phosphorylates ribose to form ribose-5-phosphate in the presence of ATP and magnesium as a first step in ribose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

RBKS Products(2)

mRNA	Protein	Name
NM_001287580.2	NP_001274509.1	ribokinase isoform 2
NM_022128.3	NP_071411.1	ribokinase isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	31515488	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBKS Protein Structure

PfkB

0
100
200
300
322 a.a.

Protein Preferred Names

Protein Names

ribokinase

RBKS Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RBKS	Q9H477	NSF	Homo sapiens	P46459	Anti Tag CoIP	28514442
Intra	RBKS	Q9H477	RBKS	Homo sapiens	Q9H477	Y2H Prey Pooling	32296183
Intra	RBKS	Q9H477	RPS4Y1	Homo sapiens	P22090	Anti Tag CoIP	33961781
Intra	RBKS	Q9H477	RBKS	Homo sapiens	Q9H477	Y2H Array	32296183
Intra	RBKS	Q9H477	ACD	Homo sapiens	Q96AP0	Pull Down	21044950
Intra	RBKS	Q9H477	ACD	Homo sapiens	Q96AP0	BiFC	21044950
Intra	RBKS	Q9H477	RBKS	Homo sapiens	Q9H477	Validated Y2H	32296183
Intra	RBKS	Q9H477	PTGR3	Homo sapiens	Q8N4Q0	Anti Tag CoIP	33961781
Intra	RBKS	Q9H477	NAPA	Homo sapiens	P54920	Anti Tag CoIP	33961781
Intra	RBKS	Q9H477	RBKS	Homo sapiens	Q9H477	Y2H Array	31515488
Intra	RBKS	Q9H477	TUBB2B	Homo sapiens	Q9BVA1	Anti Tag CoIP	33961781
Intra	RBKS	Q9H477	NSF	Homo sapiens	P46459	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RBKS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76564	RBKS Protein, Human (His)	Q9H477-1 (M1-F322)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11728	RBKS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RBKS	VGNC	VGNC:76575
Rattus norvegicus	RBKS	RGD	RGD:1310064
Canis familiaris	RBKS	VGNC	VGNC:45401
Mus musculus	RBKS	MGD	MGI:1918586
Bos taurus	RBKS	VGNC	VGNC:33780
Felis catus	RBKS	VGNC	VGNC:64518
Others	RBKS	NCBI

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