PBLD - phenazine biosynthesis like protein domain containing Gene

Homo sapiens

Also known as MAWBP; MAWDBP; HEL-S-306

Gene ID: 64081 | Gene type: protein coding

About PBLD

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:68,282,660-68,332,928 (from NCBI)

This gene has 7 transcripts (splice variants) and 223 orthologues. Biased expression in kidney (RPKM 94.0), duodenum (RPKM 62.5) and 5 other tissues.

Summary

Enables identical protein binding activity. Involved in maintenance of gastrointestinal epithelium; negative regulation of SMAD protein signal transduction; and negative regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PBLD Products(2)

mRNA	Protein	Name
NM_001033083.2	NP_001028255.1	phenazine biosynthesis-like domain-containing protein isoform b
NM_022129.4	NP_071412.2	phenazine biosynthesis-like domain-containing protein isoform a

PBLD Protein Structure

PhzC-PhzF

0
100
200
288 a.a.

Protein Preferred Names

Protein Names

phenazine biosynthesis-like domain-containing protein

MAWD-binding protein

PBLD Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PBLD	P30039	CCDC184	Homo sapiens	Q52MB2	Y2H Prey Pooling	32296183
Intra	PBLD	P30039	CCDC184	Homo sapiens	Q52MB2	Validated Y2H	32296183
Intra	PBLD	P30039	CCDC184	Homo sapiens	Q52MB2	Y2H Array	25416956
Intra	PBLD	P30039	CCDC184	Homo sapiens	Q52MB2	Y2H Array	32296183
Intra	PBLD	P30039	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	32296183
Intra	PBLD	P30039	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	32296183
Intra	PBLD	P30039	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
Intra	PBLD	P30039	AMOT	Homo sapiens	A2BDD9	Y2H Array	32296183
Intra	PBLD	P30039	AMOT	Homo sapiens	A2BDD9	Y2H Prey Pooling	32296183
Intra	PBLD	P30039	VAC14	Homo sapiens	Q08AM6	Validated Y2H	32296183
Intra	PBLD	P30039	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	PBLD	P30039	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	PBLD	P30039	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	25416956
Intra	PBLD	P30039	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	25416956
Intra	PBLD	P30039	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	PBLD	P30039	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	32296183
Intra	PBLD	P30039	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	PBLD	P30039	TRIP13	Homo sapiens	Q15645	Validated Y2H	25416956
Intra	PBLD	P30039	TRIP13	Homo sapiens	Q15645	Y2H Array	25416956
Intra	PBLD	P30039	ZRANB1	Homo sapiens	Q9UGI0	Anti Tag CoIP	33961781
Intra	PBLD	P30039	ZRANB1	Homo sapiens	Q9UGI0	Anti Tag CoIP	28514442
Intra	PBLD	P30039	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	PBLD	P30039	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	PBLD	P30039	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	PBLD	P30039	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	PBLD	P30039	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	PBLD	P30039	GRAP2	Homo sapiens	O75791	Y2H Prey Pooling	32296183
Intra	PBLD	P30039	GRAP2	Homo sapiens	O75791	Y2H Array	32296183
Intra	PBLD	P30039	PBLD	Homo sapiens	P30039	Validated Y2H	32296183
Intra	PBLD	P30039	PBLD	Homo sapiens	P30039	Y2H Array	25416956
Intra	PBLD	P30039	PBLD	Homo sapiens	P30039	Y2H Array	32296183
Intra	PBLD	P30039	PBLD	Homo sapiens	P30039	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PBLD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71144	PBLD Protein, Human (His)	P30039-1(M1-A288)	≥95%

Related Diseases

Diseases

Alias

Retinal Arteries, Tortuosity Of

Retinal Arterial Tortuosity	Retinal Hemorrhage With Vascular Tortuosity
RATOR	Tortuosity Of Retinal Arteries
Retinal Arteriolar Tortuosity	Familial Isolated Retinal Arterial Tortuosity
Tortuosity, Arteries, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N3561	Cedrelone	Inducer	/	Unkown
HY-RS10104	PBLD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PBLD	MGD	MGI:1915621
Rattus norvegicus	PBLD	RGD	RGD:621263
Felis catus	PBLD	VGNC	VGNC:64055
Macaca mulatta	PBLD	VGNC	VGNC:75669
Bos taurus	PBLD	VGNC	VGNC:32605
Canis familiaris	PBLD	VGNC	VGNC:44284
Others	PBLD	NCBI

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