2. Gene
  3. GRAP2 - GRB2 related adaptor protein 2 Gene

GRAP2 - GRB2 related adaptor protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2

Gene ID: 9402 | Gene type: protein coding

About GRAP2

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,893,820-39,973,721 (from NCBI)

This gene has 7 transcripts (splice variants), 260 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 6.7), spleen (RPKM 4.1) and 17 other tissues.

Summary

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with Other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GRAP2 Products(5)

mRNA Protein Name
NM_001291824.2 NP_001278753.1 GRB2-related adapter protein 2 isoform 1
NM_001291825.1 NP_001278754.1 GRB2-related adapter protein 2 isoform 1
NM_001291826.2 NP_001278755.1 GRB2-related adapter protein 2 isoform 2
NM_001291828.2 NP_001278757.1 GRB2-related adapter protein 2 isoform 3
NM_004810.4 NP_004801.1 GRB2-related adapter protein 2 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12359715 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21179510 GOA
located in endosome IDA
IDA: Inferred from direct assay
21179510 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21179510 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRAP2 Protein Structure

SH3_1

SH3_1: SH3 domain (4 - 47)

SH2

SH2: SH2 domain (58 - 132)

SH3_1

SH3_1: SH3 domain (277 - 322)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
Protein Preferred Names Protein Names

GRB2-related adapter protein 2

GRB-2-like protein

GRAP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra GRAP2 O75791 ZNF250 Homo sapiens P15622-3
Validated Y2H
32296183
Intra GRAP2 O75791 ZSCAN21 Homo sapiens Q9Y5A6
Anti Tag CoIP
33961781
Intra GRAP2 O75791 ZSCAN21 Homo sapiens Q9Y5A6
Anti Tag CoIP
28514442
Intra GRAP2 O75791 ZSCAN21 Homo sapiens Q9Y5A6
Validated Y2H
32296183
Intra GRAP2 O75791 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra GRAP2 O75791 PRR35 Homo sapiens P0CG20
Validated Y2H
32296183
Intra GRAP2 O75791 ZNF319 Homo sapiens Q9P2F9
Validated Y2H
32296183
Intra GRAP2 O75791 KIT Homo sapiens P10721
FPS
24728074
Intra GRAP2 O75791 PRKAA2 Homo sapiens P54646
Validated Y2H
32296183
Cross GRAP2 O75791 Kcnma1 Mus musculus Q08460
Protein Array
17065230
Intra GRAP2 O75791 MOS Homo sapiens P00540
Validated Y2H
32296183
Intra GRAP2 O75791 RAVER1 Homo sapiens Q8IY67
Validated Y2H
32296183
Intra GRAP2 O75791 EGFR Homo sapiens P00533
Lumier
24658140
Intra GRAP2 O75791 EGFR Homo sapiens P00533
Ub Reconstruction
24658140
Intra GRAP2 O75791 EGFR Homo sapiens P00533
Ub Reconstruction
31980649
Intra GRAP2 O75791 GAREM1 Homo sapiens Q9H706
Validated Y2H
32296183
Intra GRAP2 O75791 GAREM1 Homo sapiens Q9H706
Anti Tag CoIP
33961781
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
X-Ray Diffraction
17010654
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
Validated Y2H
32296183
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
Anti Tag CoIP
17235283
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
Lumier
37398436
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
MAPPIT
32296183
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
SPR
17235283
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
Y2H Array
25416956
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
Complementation
32296183
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
BFG-2H
27107012
Intra GRAP2 O75791 STAMBP Homo sapiens O95630
Y2H
16730941
Intra GRAP2 O75791 STAMBP Homo sapiens O95630
Y2H Array
31515488
Intra GRAP2 O75791 STAMBP Homo sapiens O95630
Anti Tag CoIP
33961781
Intra GRAP2 O75791 STAMBP Homo sapiens O95630
Y2H Pooling
16189514
Intra GRAP2 O75791 STAMBP Homo sapiens O95630
Anti Tag CoIP
28514442
Intra GRAP2 O75791 GAB1 Homo sapiens Q13480
Pull Down
10913131
Intra GRAP2 O75791 GAB1 Homo sapiens Q13480
Anti Tag CoIP
33961781
Intra GRAP2 O75791 GAB1 Homo sapiens Q13480
FPS
24728074
Intra GRAP2 O75791 ERBB2 Homo sapiens P04626
Protein Array
16273093
Intra GRAP2 O75791 PTPN23 Homo sapiens Q9H3S7
Anti Tag CoIP
33961781
Intra GRAP2 O75791 PTPN23 Homo sapiens Q9H3S7
Far-WB
21179510
Intra GRAP2 O75791 PTPN23 Homo sapiens Q9H3S7
IF
21179510
Intra GRAP2 O75791 PTPN23 Homo sapiens Q9H3S7
Anti Tag CoIP
28514442
Intra GRAP2 O75791 LNX1 Homo sapiens Q8TBB1
BFG-2H
27107012
Intra GRAP2 O75791 SPRY2 Homo sapiens O43597
Validated Y2H
25416956
Intra GRAP2 O75791 SH2D4A Homo sapiens Q9H788
Validated Y2H
32296183
Intra GRAP2 O75791 PBLD Homo sapiens P30039
Validated Y2H
32296183
Intra GRAP2 O75791 q7z783_human Homo sapiens Q7Z783
Validated Y2H
32296183
Intra GRAP2 O75791 GAB2 Homo sapiens Q9UQC2
Anti Tag CoIP
33961781
Intra GRAP2 O75791 GAB2 Homo sapiens Q9UQC2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib

IGHD1B

Ighd Ib

Growth Hormone Deficiency, Isolated, Type Ib

Congenital Ighd Type Ib

Congenital Isolated Gh Deficiency Type Ib

Congenital Isolated Growth Hormone Deficiency Type Ib

Dwarfism Of Sindh

Pituitary Dwarfism I

Isolated Growth Hormone Deficiency Type 1b

Ighd 1b

Growth Hormone Deficiency, Isolated, 1b
Generalized Anxiety Disorder

Anxiety Generalized
Hypochondriasis

Hypochondriacal Disorder

Hypochondria

Hypochondriacal Neurosis

Illness Anxiety Disorder

Health Anxiety Disorder

Hypochondriacal Reaction
Somatization Disorder

Somatoform Disorders

Briquet'S Disorder

Polysomatising Disorder

Somatisation Disorder

Somatoform Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05776 GRAP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GRAP2 VGNC VGNC:73156
Canis familiaris GRAP2 VGNC VGNC:41470
Rattus norvegicus GRAP2 RGD RGD:1307605
Bos taurus GRAP2 VGNC VGNC:29627
Felis catus GRAP2 VGNC VGNC:67455
Mus musculus GRAP2 MGD MGI:1333842