2. Gene
  3. NPVF - neuropeptide VF precursor Gene

NPVF - neuropeptide VF precursor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RFRP; C7orf9

Gene ID: 64111 | Gene type: protein coding

About NPVF

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:25,224,570-25,228,486 (from NCBI)

This gene has 1 transcript (splice variant) and 161 orthologues.

Summary

Predicted to enable signaling receptor binding activity. Involved in negative regulation of gonadotropin secretion. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

NPVF Products(1)

mRNA Protein Name
NM_022150.3 NP_071433.3 pro-FMRFamide-related neuropeptide VF precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
NOT enables neuropeptide activity IDA
IDA: Inferred from direct assay
18752651 GOA
enables neuropeptide activity IDA
IDA: Inferred from direct assay
11025660 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of gonadotropin secretion IDA
IDA: Inferred from direct assay
20027225 GOA
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
11025660 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pro-FMRFamide-related neuropeptide VF

FMRFamide-related peptide

NPVF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NPVF Q9HCQ7 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
NPVF Q9HCQ7 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
NPVF Q9HCQ7 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
NPVF Q9HCQ7 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
NPVF Q9HCQ7 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Precocious Puberty, Central, 1

CPPB1

Central Precocious Puberty 1

Precocious Puberty, Central 1

Puberty, Precocious, Central, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1250 RFRP-3(human) Agonist 99.21% Unkown
HY-P10780 RFRP-3 (mouse) / Unkown
HY-P1250A RFRP-3(human) TFA Agonist / Unkown
HY-RS09508 NPVF Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NPVF RGD RGD:61815
Mus musculus NPVF MGD MGI:1926488
Felis catus NPVF VGNC VGNC:80642
Bos taurus NPVF VGNC VGNC:32221
Macaca mulatta NPVF VGNC VGNC:75168
Canis familiaris NPVF VGNC VGNC:43935