2. Gene
  3. PALS1 - protein associated with LIN7 1, MAGUK p55 family member Gene

PALS1 - protein associated with LIN7 1, MAGUK p55 family member Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MPP5

Gene ID: 64398 | Gene type: protein coding

About PALS1

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:67,241,435-67,336,061 (from NCBI)

This gene has 13 transcripts (splice variants), 278 orthologues, 7 paralogues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 15.8), thyroid (RPKM 14.7) and 25 other tissues.

Summary

This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

PALS1 Products(2)

mRNA Protein Name
NM_001256550.2 NP_001243479.1 protein PALS1 isoform 2
NM_022474.4 NP_071919.2 protein PALS1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
15914641 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11927608 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
17332497 GOA
Biological Process GO Annotation Evidence Reference Source
involved in morphogenesis of an epithelial sheet IMP
IMP: Inferred from mutant phenotype
23201090 GOA
Cellular Component GO Annotation Evidence Reference Source
located in adherens junction IDA
IDA: Inferred from direct assay
15914641 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
15914641 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PALS1 Protein Structure

L27_N

L27_N: L27_N (123 - 170)

L27

L27: L27 domain (201 - 231)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (258 - 331)

SH3_2

SH3_2: Variant SH3 domain (349 - 411)

Guanylate_kin

Guanylate_kin: Guanylate kinase (479 - 661)

  • 0
  • 200
  • 400
  • 600
  • 675 a.a.
Protein Preferred Names Protein Names

protein PALS1

MAGUK p55 subfamily member 5

PALS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PALS1 Q8N3R9 FTCD Homo sapiens O95954
Y2H Array
32296183
Intra
PALS1 Q8N3R9 FTCD Homo sapiens O95954
Y2H Prey Pooling
32296183
Intra
PALS1 Q8N3R9 EPB41L5 Homo sapiens Q9HCM4
Y2H
17920587
Intra
PALS1 Q8N3R9 EPB41L5 Homo sapiens Q9HCM4
Pull Down
17920587
Intra
PALS1 Q8N3R9 EPB41L5 Homo sapiens Q9HCM4
Anti Bait CoIP
17920587
Intra
PALS1 Q8N3R9 CRB1 Homo sapiens P82279
SPR
33758649
Intra
PALS1 Q8N3R9 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra
PALS1 Q8N3R9 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra
PALS1 Q8N3R9 LIN7C Homo sapiens Q9NUP9
Y2H Prey Pooling
32296183
Intra
PALS1 Q8N3R9 LIN7C Homo sapiens Q9NUP9
Anti Tag CoIP
24366813
Intra
PALS1 Q8N3R9 LIN7C Homo sapiens Q9NUP9
Anti Tag CoIP
33961781
Intra
PALS1 Q8N3R9 LIN7C Homo sapiens Q9NUP9
Validated Y2H
32296183
Intra
PALS1 Q8N3R9 LIN7C Homo sapiens Q9NUP9
Y2H Array
32296183
Intra
PALS1 Q8N3R9 DLGAP4 Homo sapiens Q9Y2H0-1
Y2H Array
32296183
Intra
PALS1 Q8N3R9 DLGAP4 Homo sapiens Q9Y2H0-1
Validated Y2H
32296183
Intra
PALS1 Q8N3R9 DLGAP4 Homo sapiens Q9Y2H0-1
Y2H Prey Pooling
32296183
Intra
PALS1 Q8N3R9 SRGAP2B Homo sapiens A0A286YEY3
Y2H Prey Pooling
32296183
Intra
PALS1 Q8N3R9 SRGAP2B Homo sapiens A0A286YEY3
Y2H Array
32296183
Intra
PALS1 Q8N3R9 SNTG2 Homo sapiens Q9NY99-2
Y2H Prey Pooling
32296183
Intra
PALS1 Q8N3R9 SNTG2 Homo sapiens Q9NY99-2
Validated Y2H
32296183
Intra
PALS1 Q8N3R9 SNTG2 Homo sapiens Q9NY99-2
Y2H Array
32296183
Intra
PALS1 Q8N3R9 MPP4 Homo sapiens Q96JB8
Pull Down
15914641
Intra
PALS1 Q8N3R9 MPP4 Homo sapiens Q96JB8
Y2H
15914641
Intra
PALS1 Q8N3R9 MPP4 Homo sapiens Q96JB8
Anti Bait CoIP
15914641
Intra
PALS1 Q8N3R9 MPP4 Homo sapiens Q96JB8
Anti Tag CoIP
15914641
Intra
PALS1 Q8N3R9 LIN7A Homo sapiens O14910
Anti Tag CoIP
33961781
Cross
PALS1 Q8N3R9 E SARS-CoV-2 P0DTC4
MST
34103506
Intra
PALS1 Q8N3R9 AMOT Homo sapiens Q4VCS5
Anti Tag CoIP
24366813
Cross
PALS1 Q8N3R9 E SARS-CoV-2 P0DTC4
3D-EM
34103506
Cross
PALS1 Q8N3R9 E SARS-CoV-2 P0DTC4
2D-IR
32822073
Intra
PALS1 Q8N3R9 LIN7A Homo sapiens O14910
Validated Y2H
25416956
Intra
PALS1 Q8N3R9 LIN7A Homo sapiens O14910
Y2H Prey Pooling
32296183
Intra
PALS1 Q8N3R9 LIN7A Homo sapiens O14910
Anti Tag CoIP
24366813
Cross
PALS1 Q8N3R9 E SARS-CoV-2 P0DTC4
FRET
32822073
Intra
PALS1 Q8N3R9 AMOT Homo sapiens Q4VCS5
Anti Tag CoIP
33961781
Intra
PALS1 Q8N3R9 LIN7A Homo sapiens O14910
Y2H Array
25416956
Cross
PALS1 Q8N3R9 E SARS-CoV-2 P0DTC4
SPR
33758649
Intra
PALS1 Q8N3R9 LIN7A Homo sapiens O14910
Y2H Array
32296183
Intra
PALS1 Q8N3R9 AMOT Homo sapiens Q4VCS5
Anti Tag CoIP
21481793
Cross
PALS1 Q8N3R9 E Human SARS coronavirus P59637
SPR
33758649
Cross
PALS1 Q8N3R9 E Human SARS coronavirus P59637
2D-IR
32822073
Cross
PALS1 Q8N3R9 E Human SARS coronavirus P59637
FRET
32822073
Intra
PALS1 Q8N3R9 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
PALS1 Q8N3R9 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
PALS1 Q8N3R9 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
PALS1 Q8N3R9 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
PALS1 Q8N3R9 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
PALS1 Q8N3R9 TTR Homo sapiens P02766
Validated Y2H
32814053
Intra
PALS1 Q8N3R9 TTR Homo sapiens P02766
Y2H Array
32814053
Intra
PALS1 Q8N3R9 TTR Homo sapiens P02766
Y2H Pooling
32814053
Intra
PALS1 Q8N3R9 PATJ Homo sapiens Q8NI35
Anti Tag CoIP
33961781
Intra
PALS1 Q8N3R9 PATJ Homo sapiens Q8NI35
Anti Tag CoIP
24366813
Intra
PALS1 Q8N3R9 PATJ Homo sapiens Q8NI35
Anti Tag CoIP
21481793
Intra
PALS1 Q8N3R9 LIN7B Homo sapiens Q9HAP6
Y2H Prey Pooling
32296183
Intra
PALS1 Q8N3R9 LIN7B Homo sapiens Q9HAP6
Validated Y2H
32296183
Intra
PALS1 Q8N3R9 LIN7B Homo sapiens Q9HAP6
Y2H Array
32296183
Intra
PALS1 Q8N3R9 LIN7B Homo sapiens Q9HAP6
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Arachnoid Cysts, Intracranial

Arachnoid Cyst

Arachnoid Cysts

Intracranial Arachnoid Cysts

Arachnoid Brain Cyst

Arachnoid Cerebral Cyst

Intracranium Cyst Nos
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis
Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed
Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder
Retinitis Pigmentosa 12

RP12

Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium

Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium

Rp With Or Without Pprpe

Retinitis Pigmentosa-12
Retinal Degeneration

Degeneration Of Retina
Intraorbital Meningioma
Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium

Adenosquamous Carcinoma Of The Endometrium

Endometrial Adenosquamous Cancer

Endometrial Adenosquamous Cell Carcinoma
Nephronophthisis 7

NPHP7

Nephronophthisis, Type 7
Leber Congenital Amaurosis 8

LCA8

Leber Congenital Amaurosis, Type 8
Central Sleep Apnea

Central Sleep Apnea Syndrome

Sleep Apnea, Central

Primary Central Sleep Apnea

Central Sleep Apnea, Primary

Central Sleep Apnoea Syndrome

Csa - [Central Sleep Apnoea]

Csas - [Central Sleep Apnoea Syndrome]

Central Sleep Apnoea Due To Substances Including Medications
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Late-Onset Retinal Degeneration

LORD

Retinal Degeneration, Late-Onset, Autosomal Dominant

Autosomal Dominant Late-Onset Retinal Degeneration

Pigmentary Retinopathy

Retinal Degeneration, Late-Onset

Retinitis Pigmentosa
Meckel Syndrome, Type 1

Meckel-Gruber Syndrome

Meckel Syndrome

Dysencephalia Splanchnocystica

Meckel Syndrome 1

MKS1

Mks

Gruber Syndrome

Meckel-Gruber Syndrome, Type 1

Mes

Dysencephalia Splachnocystica

Meckel Gruber Syndrome

Meckel Syndrome Type 1
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10009 PALS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PALS1 RGD RGD:1308071
Macaca mulatta PALS1 VGNC VGNC:74794
Canis familiaris PALS1 VGNC VGNC:43346
Felis catus PALS1 VGNC VGNC:80910
Bos taurus PALS1 VGNC VGNC:31584
Mus musculus PALS1 MGD MGI:1927339