DNAJC1 - DnaJ heat shock protein family (Hsp40) member C1 Gene

Homo sapiens

Also known as HTJ1; MTJ1; ERdj1; DNAJL1

Gene ID: 64215 | Gene type: protein coding

About DNAJC1

Cytogenetic location: 10p12.31 Genomic coordinates (GRCh38): 10:21,756,548-22,003,730 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 20 paralogues. Ubiquitous expression in thyroid (RPKM 13.9), prostate (RPKM 10.4) and 25 other tissues.

Summary

The membrane protein encoded by this gene is a DNAJ-like heat shock protein that binds the molecular chaperone BiP. In addition, the encoded protein contains two SANT domains that have been shown to bind serpin alpha1-antichymotrypsin and inter-alpha trypsin inhibitor heavy chain 4. [provided by RefSeq, Jul 2016]

DNAJC1 Products(1)

mRNA	Protein	Name
NM_022365.4	NP_071760.2	dnaJ homolog subfamily C member 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14668352	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of protein secretion	IDA IDA: Inferred from direct assay	14668352	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJC1 Protein Structure

DnaJ

Myb_DNA-binding

0
100
200
300
400
500
554 a.a.

Protein Preferred Names

Protein Names

dnaJ homolog subfamily C member 1

DnaJ (Hsp40) homolog, subfamily C, member 1

DNAJC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DNAJC1	Q96KC8	CYP4F2	Homo sapiens	P78329	Y2H Prey Pooling	32296183
Intra	DNAJC1	Q96KC8	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	DNAJC1	Q96KC8	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	DNAJC1	Q96KC8	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	DNAJC1	Q96KC8	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053
Intra	DNAJC1	Q96KC8	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	DNAJC1	Q96KC8	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053
Intra	DNAJC1	Q96KC8	RMND1	Homo sapiens	Q9NWS8	Anti Tag CoIP	33961781
Intra	DNAJC1	Q96KC8	RMND1	Homo sapiens	Q9NWS8	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pyometritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03872	DNAJC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DNAJC1	RGD	RGD:2322144
Macaca mulatta	DNAJC1	VGNC	VGNC:106033
Mus musculus	DNAJC1	MGD	MGI:103268
Felis catus	DNAJC1	VGNC	VGNC:83868
Canis familiaris	DNAJC1	VGNC	VGNC:52128

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