2. Gene
  3. CYP4F2 - cytochrome P450 family 4 subfamily F member 2 Gene

CYP4F2 - cytochrome P450 family 4 subfamily F member 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
Homo sapiens

Also known as CPF2

Gene ID: 8529 | Gene type: protein coding

About CYP4F2

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,878,023-15,898,074 (from NCBI)

This gene has 8 transcripts (splice variants), 433 orthologues and 12 paralogues. Biased expression in liver (RPKM 63.5), small intestine (RPKM 42.7) and 2 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum. The Enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of Cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]

CYP4F2 Products(1)

mRNA Protein Name
NM_001082.5 NP_001073.3 cytochrome P450 4F2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables alkane 1-monooxygenase activity IDA
IDA: Inferred from direct assay
18433732 GOA
enables alpha-tocopherol omega-hydroxylase activity IDA
IDA: Inferred from direct assay
20861217 GOA
enables arachidonate epoxygenase activity IDA
IDA: Inferred from direct assay
9618440 GOA
enables arachidonate omega-hydroxylase activity IDA
IDA: Inferred from direct assay
9618440 GOA
enables leukotriene-B4 20-monooxygenase activity IDA
IDA: Inferred from direct assay
8026587 GOA
enables long-chain fatty acid omega-hydroxylase activity IDA
IDA: Inferred from direct assay
15145985 GOA
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
IDA: Inferred from direct assay
19297519 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17474147 GOA
Biological Process GO Annotation Evidence Reference Source
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
10660572 GOA
involved in epoxygenase P450 pathway IDA
IDA: Inferred from direct assay
9618440 GOA
involved in fatty acid omega-oxidation IDA
IDA: Inferred from direct assay
18577768 GOA
involved in leukotriene B4 catabolic process IDA
IDA: Inferred from direct assay
8026587 GOA
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
18433732 GOA
involved in menaquinone catabolic process IDA
IDA: Inferred from direct assay
24138531 GOA
involved in negative regulation of icosanoid secretion IMP
IMP: Inferred from mutant phenotype
18391101 GOA
involved in omega-hydroxylase P450 pathway IDA
IDA: Inferred from direct assay
9799565 GOA
involved in phylloquinone catabolic process IDA
IDA: Inferred from direct assay
24138531 GOA
involved in positive regulation of icosanoid secretion IMP
IMP: Inferred from mutant phenotype
17341693 GOA
involved in pressure natriuresis IEP
IEP: Inferred from expression pattern
10660572 GOA
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
18391101 GOA
involved in renal water homeostasis IEP
IEP: Inferred from expression pattern
10660572 GOA
involved in sodium ion homeostasis IEP
IEP: Inferred from expression pattern
10660572 GOA
involved in very long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
18433732 GOA
involved in vitamin E metabolic process IDA
IDA: Inferred from direct assay
20861217 GOA
involved in vitamin K catabolic process IDA
IDA: Inferred from direct assay
19297519 GOA
involved in xenobiotic metabolic process IMP
IMP: Inferred from mutant phenotype
21084764 GOA
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10660572 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
10660572 GOA
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
9618440 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP4F2 Protein Structure

p450

p450: Cytochrome P450 (52 - 506)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
Protein Preferred Names Protein Names

cytochrome P450 4F2

20-HETE synthase

CYP4F2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CYP4F2 P78329 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
CYP4F2 P78329 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
CYP4F2 P78329 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
CYP4F2 P78329 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
CYP4F2 P78329 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
CYP4F2 P78329 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
CYP4F2 P78329 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
CYP4F2 P78329 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 SPAG4 Homo sapiens Q9NPE6
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
Intra
CYP4F2 P78329 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
Intra
CYP4F2 P78329 REEP2 Homo sapiens Q9BRK0
Y2H Array
32296183
Intra
CYP4F2 P78329 REEP2 Homo sapiens Q9BRK0
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 REEP2 Homo sapiens Q9BRK0
Validated Y2H
32296183
Intra
CYP4F2 P78329 ZDHHC15 Homo sapiens Q96MV8
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 ZDHHC15 Homo sapiens Q96MV8
Validated Y2H
32296183
Intra
CYP4F2 P78329 ZDHHC15 Homo sapiens Q96MV8
Y2H Array
32296183
Intra
CYP4F2 P78329 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra
CYP4F2 P78329 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
CYP4F2 P78329 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
CYP4F2 P78329 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
CYP4F2 P78329 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
CYP4F2 P78329 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
CYP4F2 P78329 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 SLC17A8 Homo sapiens Q8NDX2-2
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 SLC17A8 Homo sapiens Q8NDX2-2
Validated Y2H
32296183
Intra
CYP4F2 P78329 SLC17A8 Homo sapiens Q8NDX2-2
Y2H Array
32296183
Intra
CYP4F2 P78329 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
CYP4F2 P78329 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
CYP4F2 P78329 TSPAN31 Homo sapiens Q12999
Validated Y2H
32296183
Intra
CYP4F2 P78329 TSPAN31 Homo sapiens Q12999
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 TSPAN31 Homo sapiens Q12999
Y2H Array
32296183
Intra
CYP4F2 P78329 MMD Homo sapiens Q15546
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 MMD Homo sapiens Q15546
Validated Y2H
32296183
Intra
CYP4F2 P78329 MMD Homo sapiens Q15546
Y2H Array
32296183
Intra
CYP4F2 P78329 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
CYP4F2 P78329 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
CYP4F2 P78329 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
CYP4F2 P78329 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
CYP4F2 P78329 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 SLC2A13 Homo sapiens Q96QE2
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 SLC2A13 Homo sapiens Q96QE2
Validated Y2H
32296183
Intra
CYP4F2 P78329 SLC2A13 Homo sapiens Q96QE2
Y2H Array
32296183
Intra
CYP4F2 P78329 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra
CYP4F2 P78329 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
CYP4F2 P78329 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra
CYP4F2 P78329 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
CYP4F2 P78329 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
CYP4F2 P78329 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
CYP4F2 P78329 DNAJC1 Homo sapiens Q96KC8
Validated Y2H
32296183
Intra
CYP4F2 P78329 DNAJC1 Homo sapiens Q96KC8
Y2H Array
32296183
Intra
CYP4F2 P78329 NCK1 Homo sapiens P16333
Peptide Array
17474147
Intra
CYP4F2 P78329 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
CYP4F2 P78329 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
CYP4F2 P78329 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
CYP4F2 P78329 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra
CYP4F2 P78329 SLC19A3 Homo sapiens Q9BZV2
Y2H Array
32296183
Intra
CYP4F2 P78329 SLC19A3 Homo sapiens Q9BZV2
Validated Y2H
32296183
Intra
CYP4F2 P78329 SLC19A3 Homo sapiens Q9BZV2
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 CREB3 Homo sapiens O43889-2
Validated Y2H
25910212
Intra
CYP4F2 P78329 CREB3 Homo sapiens O43889-2
Y2H Array
25910212
Intra
CYP4F2 P78329 CREB3 Homo sapiens O43889-2
Y2H Bait-Prey Pool
25910212
Intra
CYP4F2 P78329 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
CYP4F2 P78329 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
CYP4F2 P78329 TM4SF19 Homo sapiens Q96DZ7
Validated Y2H
32296183
Intra
CYP4F2 P78329 TM4SF19 Homo sapiens Q96DZ7
Y2H Array
32296183
Intra
CYP4F2 P78329 TM4SF19 Homo sapiens Q96DZ7
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
CYP4F2 P78329 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
CYP4F2 P78329 SDHAF2 Homo sapiens Q9NX18
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 SDHAF2 Homo sapiens Q9NX18
Validated Y2H
32296183
Intra
CYP4F2 P78329 SDHAF2 Homo sapiens Q9NX18
Y2H Array
32296183
Intra
CYP4F2 P78329 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra
CYP4F2 P78329 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 TMEM51 Homo sapiens Q9NW97
Validated Y2H
32296183
Intra
CYP4F2 P78329 THAP4 Homo sapiens Q8WY91
Validated Y2H
32296183
Intra
CYP4F2 P78329 THAP4 Homo sapiens Q8WY91
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 THAP4 Homo sapiens Q8WY91
Y2H Array
32296183
Intra
CYP4F2 P78329 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra
CYP4F2 P78329 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
CYP4F2 P78329 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
CYP4F2 P78329 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
CYP4F2 P78329 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
CYP4F2 P78329 ROM1 Homo sapiens Q03395
Validated Y2H
32296183
Intra
CYP4F2 P78329 ROM1 Homo sapiens Q03395
Y2H Array
32296183
Intra
CYP4F2 P78329 ROM1 Homo sapiens Q03395
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 PLEKHO1 Homo sapiens Q53GL0
Y2H Prey Pooling
32296183
Intra
CYP4F2 P78329 PLEKHO1 Homo sapiens Q53GL0
Validated Y2H
32296183
Intra
CYP4F2 P78329 PLEKHO1 Homo sapiens Q53GL0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Coumarin Resistance

Warfarin Resistance

Warfarin Sensitivity

Coumadin Sensitivity

Warfarin Response

Poor Metabolism Of Coumarin

Coumarin, Poor Metabolism Of

CMRES
Atrial Fibrillation

A-Fib

Fibrillation, Atrial

Af - [Atrial Fibrillation]

Rapid Atrial Fibrillation

A Fib - [Atrial Fibrillation]
Thrombosis

Thrombosis Of Blood Vessel
Inflammatory Bowel Disease 6

IBD6
Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis
Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis

Congenital Ichthyosiform Erythroderma

Li

Congenital Nonbullous Ichthyosiform Erythroderma

Arci

Congenital Lamellar Ichthyosis

Nonbullous Congenital Ichthyosiform Erythroderma

Cie

Congenital Non-Bullous Ichthyosiform Erythroderma

Erythrodermic Ichthyosis

Nbcie

Ncie

Non-Bullous Congenital Ichthyosiform Erythroderma

Collodion Baby

Ichthyosis, Lamellar

Non Bullous Congenital Ichthyosiform Erythroderma

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Collodion Baby Syndrome

Ichthyoses, Lamellar

Nbie

Nonbullous Ichthyosiform Erythroderma

Classic Lamellar Ichthyosis

Ichthyosiform Erythroderma Nonbullous Congenital

Ichthyosiform Erythroderma Congenital

Ichthyosis, Congenital, Autosomal Recessive

Ichthyosiform Erythroderma, Congenital

Collodion Fetus

Non-Bullous Ichthyosiform Erythroderma
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-151810 TP0472993 Inhibitor 98.69% Unkown
HY-151809 CYP4A11/CYP4F2-IN-1 Inhibitor 99.82% Unkown
HY-149770 CYP4A11/CYP4F2-IN-2 Inhibitor / Unkown
HY-E70487 Human CYP4F2,Low-Reductase+b5 / Unkown
HY-RS03480 CYP4F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W472509 11-HETE Activator / Unkown