1. Gene
  2. UBE2E3 - ubiquitin conjugating enzyme E2 E3 Gene

UBE2E3 - ubiquitin conjugating enzyme E2 E3 Gene

Homo sapiens

Also known as UBCH9; UbcM2

Gene ID: 10477 | Gene type: protein coding

About UBE2E3

Cytogenetic location: 2q31.3 Genomic coordinates (GRCh38): 2:180,980,360-181,063,425 (from NCBI)

This gene has 14 transcripts (splice variants), 164 orthologues and 12 paralogues. Ubiquitous expression in gall bladder (RPKM 6.0), thyroid (RPKM 5.9) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this Enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]

UBE2E3 Products(4)

mRNA Protein Name
NM_001278554.2 NP_001265483.1 ubiquitin-conjugating enzyme E2 E3
NM_001278555.2 NP_001265484.1 ubiquitin-conjugating enzyme E2 E3
NM_006357.4 NP_006348.1 ubiquitin-conjugating enzyme E2 E3
NM_182678.3 NP_872619.1 ubiquitin-conjugating enzyme E2 E3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14667819 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
20061386 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2E3 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (65 - 201)

  • 0
  • 100
  • 207 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 E3

E2 ubiquitin-conjugating enzyme E3

UBE2E3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UBE2E3 Q969T4 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
UBE2E3 Q969T4 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
UBE2E3 Q969T4 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
UBE2E3 Q969T4 OTUB1 Homo sapiens Q96FW1 33961781
Intra
UBE2E3 Q969T4 OTUB1 Homo sapiens Q96FW1 28514442
Intra
UBE2E3 Q969T4 OTUB1 Homo sapiens Q96FW1 32296183
Intra
UBE2E3 Q969T4 KIF1B Homo sapiens O60333-2 32814053
Intra
UBE2E3 Q969T4 KIF1B Homo sapiens O60333-2 32814053
Intra
UBE2E3 Q969T4 KIF1B Homo sapiens O60333-2 32814053
Intra
UBE2E3 Q969T4 TRIM39 Homo sapiens Q9HCM9-2 32296183
Intra
UBE2E3 Q969T4 TRIM39 Homo sapiens Q9HCM9-2 32296183
Intra
UBE2E3 Q969T4 TRIM39 Homo sapiens Q9HCM9-2 32296183
Intra
UBE2E3 Q969T4 CHFR Homo sapiens Q96EP1-2 32296183
Intra
UBE2E3 Q969T4 CHFR Homo sapiens Q96EP1-2 32296183
Intra
UBE2E3 Q969T4 CHFR Homo sapiens Q96EP1-2 32296183
Intra
UBE2E3 Q969T4 PGPEP1 Homo sapiens Q9NXJ5-2 32296183
Intra
UBE2E3 Q969T4 RNF25 Homo sapiens Q96BH1 28514442
Intra
UBE2E3 Q969T4 RNF25 Homo sapiens Q96BH1 19549727
Intra
UBE2E3 Q969T4 RNF25 Homo sapiens Q96BH1 33961781
Intra
UBE2E3 Q969T4 RNF115 Homo sapiens Q9Y4L5 32296183
Intra
UBE2E3 Q969T4 RNF115 Homo sapiens Q9Y4L5 19690564
Intra
UBE2E3 Q969T4 RNF115 Homo sapiens Q9Y4L5 32296183
Intra
UBE2E3 Q969T4 RNF115 Homo sapiens Q9Y4L5 32296183
Intra
UBE2E3 Q969T4 RNF185 Homo sapiens Q96GF1 31515488
Intra
UBE2E3 Q969T4 RNF185 Homo sapiens Q96GF1 25416956
Intra
UBE2E3 Q969T4 RNF185 Homo sapiens Q96GF1 19549727
Intra
UBE2E3 Q969T4 RNF185 Homo sapiens Q96GF1 25416956
Intra
UBE2E3 Q969T4 RNF185 Homo sapiens Q96GF1 32296183
Intra
UBE2E3 Q969T4 RNF185 Homo sapiens Q96GF1 32296183
Intra
UBE2E3 Q969T4 RNF185 Homo sapiens Q96GF1 32296183
Intra
UBE2E3 Q969T4 MID1 Homo sapiens O15344 25416956
Intra
UBE2E3 Q969T4 MID1 Homo sapiens O15344 25416956
Intra
UBE2E3 Q969T4 MID1 Homo sapiens O15344 32296183
Intra
UBE2E3 Q969T4 MID1 Homo sapiens O15344 25416956
Intra
UBE2E3 Q969T4 MID1 Homo sapiens O15344 32296183
Intra
UBE2E3 Q969T4 ARRDC3 Homo sapiens Q96B67 32296183
Intra
UBE2E3 Q969T4 ARRDC3 Homo sapiens Q96B67 32296183
Intra
UBE2E3 Q969T4 ARRDC3 Homo sapiens Q96B67 32296183
Intra
UBE2E3 Q969T4 RNF5 Homo sapiens Q99942 25416956
Intra
UBE2E3 Q969T4 RNF5 Homo sapiens Q99942 32296183
Intra
UBE2E3 Q969T4 RNF5 Homo sapiens Q99942 32296183
Intra
UBE2E3 Q969T4 RNF5 Homo sapiens Q99942 25416956
Intra
UBE2E3 Q969T4 RNF5 Homo sapiens Q99942 32296183
Intra
UBE2E3 Q969T4 HSPB1 Homo sapiens P04792 32814053
Intra
UBE2E3 Q969T4 HSPB1 Homo sapiens P04792 32814053
Intra
UBE2E3 Q969T4 HSPB1 Homo sapiens P04792 32814053
Intra
UBE2E3 Q969T4 RNF11 Homo sapiens Q9Y3C5 32814053
Intra
UBE2E3 Q969T4 RNF11 Homo sapiens Q9Y3C5 32814053
Intra
UBE2E3 Q969T4 RNF11 Homo sapiens Q9Y3C5 32814053
Intra
UBE2E3 Q969T4 TRIM62 Homo sapiens Q9BVG3 32296183
Intra
UBE2E3 Q969T4 TRIM62 Homo sapiens Q9BVG3 32296183
Intra
UBE2E3 Q969T4 TRIM62 Homo sapiens Q9BVG3 32296183
Intra
UBE2E3 Q969T4 TTR Homo sapiens P02766 32814053
Intra
UBE2E3 Q969T4 TTR Homo sapiens P02766 32814053
Intra
UBE2E3 Q969T4 TTR Homo sapiens P02766 32814053
Intra
UBE2E3 Q969T4 RNF10 Homo sapiens Q8N5U6 33961781
Intra
UBE2E3 Q969T4 WFS1 Homo sapiens O76024 32814053
Intra
UBE2E3 Q969T4 WFS1 Homo sapiens O76024 32814053
Intra
UBE2E3 Q969T4 WFS1 Homo sapiens O76024 32814053
Intra
UBE2E3 Q969T4 RNF2 Homo sapiens Q99496 32296183
Intra
UBE2E3 Q969T4 RNF2 Homo sapiens Q99496 32296183
Intra
UBE2E3 Q969T4 RNF2 Homo sapiens Q99496 19549727
Intra
UBE2E3 Q969T4 RNF2 Homo sapiens Q99496 32296183
Intra
UBE2E3 Q969T4 DAZAP2 Homo sapiens Q15038 32296183
Intra
UBE2E3 Q969T4 DAZAP2 Homo sapiens Q15038 32296183
Intra
UBE2E3 Q969T4 WBP2 Homo sapiens Q969T9 32296183
Intra
UBE2E3 Q969T4 WBP2 Homo sapiens Q969T9 32296183
Intra
UBE2E3 Q969T4 WBP2 Homo sapiens Q969T9 32296183
Intra
UBE2E3 Q969T4 TRIM39 Homo sapiens Q9HCM9 25416956
Intra
UBE2E3 Q969T4 WWP2 Homo sapiens O00308 32296183
Intra
UBE2E3 Q969T4 WWP2 Homo sapiens O00308 32296183
Intra
UBE2E3 Q969T4 PRPS1 Homo sapiens P60891 32814053
Intra
UBE2E3 Q969T4 PRPS1 Homo sapiens P60891 32814053
Intra
UBE2E3 Q969T4 PRPS1 Homo sapiens P60891 32814053
Intra
UBE2E3 Q969T4 PICK1 Homo sapiens Q9NRD5 32296183
Intra
UBE2E3 Q969T4 PICK1 Homo sapiens Q9NRD5 32296183
Intra
UBE2E3 Q969T4 PICK1 Homo sapiens Q9NRD5 32296183
Intra
UBE2E3 Q969T4 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra
UBE2E3 Q969T4 RNF220 Homo sapiens Q5VTB9 33961781
Intra
UBE2E3 Q969T4 RNF220 Homo sapiens Q5VTB9 28514442
Intra
UBE2E3 Q969T4 RNF220 Homo sapiens Q5VTB9
Y2H
19549727
Intra
UBE2E3 Q969T4 TRIM50 Homo sapiens Q86XT4 32296183
Intra
UBE2E3 Q969T4 TRIM50 Homo sapiens Q86XT4 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus UBE2E3 RGD RGD:1308894
Felis catus UBE2E3 VGNC VGNC:107686
Mus musculus UBE2E3 MGD MGI:107412
Canis familiaris UBE2E3 VGNC VGNC:53110
Macaca mulatta UBE2E3 VGNC VGNC:99418
Bos taurus UBE2E3 VGNC VGNC:56154
Others UBE2E3 NCBI