UBE2E3 - ubiquitin conjugating enzyme E2 E3 Gene

Homo sapiens

Also known as UBCH9; UbcM2

Gene ID: 10477 | Gene type: protein coding

About UBE2E3

Cytogenetic location: 2q31.3 Genomic coordinates (GRCh38): 2:180,980,360-181,063,425 (from NCBI)

This gene has 14 transcripts (splice variants), 164 orthologues and 12 paralogues. Ubiquitous expression in gall bladder (RPKM 6.0), thyroid (RPKM 5.9) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this Enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]

UBE2E3 Products(4)

mRNA	Protein	Name
NM_001278554.2	NP_001265483.1	ubiquitin-conjugating enzyme E2 E3
NM_001278555.2	NP_001265484.1	ubiquitin-conjugating enzyme E2 E3
NM_006357.4	NP_006348.1	ubiquitin-conjugating enzyme E2 E3
NM_182678.3	NP_872619.1	ubiquitin-conjugating enzyme E2 E3

UBE2E3 Protein Structure

UQ_con

0
100
207 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 E3

E2 ubiquitin-conjugating enzyme E3

Related Diseases

Diseases

Alias

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15344	UBE2E3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UBE2E3	RGD	RGD:1308894
Felis catus	UBE2E3	VGNC	VGNC:107686
Mus musculus	UBE2E3	MGD	MGI:107412
Canis familiaris	UBE2E3	VGNC	VGNC:53110
Macaca mulatta	UBE2E3	VGNC	VGNC:99418
Bos taurus	UBE2E3	VGNC	VGNC:56154
Others	UBE2E3	NCBI

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