ZMAT3 - zinc finger matrin-type 3 Gene

Homo sapiens

Also known as WIG1; WIG-1; PAG608

Gene ID: 64393 | Gene type: protein coding

About ZMAT3

Cytogenetic location: 3q26.32 Genomic coordinates (GRCh38): 3:179,017,223-179,072,513 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 9 paralogues. Ubiquitous expression in brain (RPKM 11.2), gall bladder (RPKM 5.6) and 24 other tissues.

Summary

This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]

ZMAT3 Products(8)

mRNA	Protein	Name
NM_001375824.1	NP_001362753.1	zinc finger matrin-type protein 3 isoform 1
NM_001375825.1	NP_001362754.1	zinc finger matrin-type protein 3 isoform 1
NM_001375826.1	NP_001362755.1	zinc finger matrin-type protein 3 isoform 2
NM_001375827.1	NP_001362756.1	zinc finger matrin-type protein 3 isoform 2
NM_001375828.1	NP_001362757.1	zinc finger matrin-type protein 3 isoform 2
NM_001375829.1	NP_001362758.1	zinc finger matrin-type protein 3 isoform 2
NM_022470.4	NP_071915.1	zinc finger matrin-type protein 3 isoform 1
NM_152240.3	NP_689426.1	zinc finger matrin-type protein 3 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18519039	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMAT3 Protein Structure

zf-met

zf-C2H2_jaz

0
100
200
289 a.a.

Protein Preferred Names

Protein Names

zinc finger matrin-type protein 3

WIG-1/PAG608 protein

ZMAT3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZMAT3	Q9HA38	HNRNPA2B1	Homo sapiens	P22626	Anti Tag CoIP	18519039
Intra	ZMAT3	Q9HA38	HNRNPA2B1	Homo sapiens	P22626	Anti Bait CoIP	18519039
Intra	ZMAT3	Q9HA38	DHX9	Homo sapiens	Q08211	Anti Bait CoIP	18519039
Intra	ZMAT3	Q9HA38	DHX9	Homo sapiens	Q08211	Anti Tag CoIP	18519039
Intra	ZMAT3	Q9HA38	STAU1	Homo sapiens	O95793	Validated Y2H	25416956
Intra	ZMAT3	Q9HA38	STAU1	Homo sapiens	O95793	Y2H Prey Pooling	25416956
Intra	ZMAT3	Q9HA38	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	23085987
Intra	ZMAT3	Q9HA38	AGO2	Homo sapiens	Q9UKV8	Pull Down	23085987
Intra	ZMAT3	Q9HA38	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	23085987
Intra	ZMAT3	Q9HA38	PRKRA	Homo sapiens	O75569	Y2H Array	25416956
Intra	ZMAT3	Q9HA38	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	ZMAT3	Q9HA38	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	ZMAT3	Q9HA38	TARBP2	Homo sapiens	Q15633	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16085	ZMAT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZMAT3	MGD	MGI:1195270
Bos taurus	ZMAT3	VGNC	VGNC:37192
Macaca mulatta	ZMAT3	VGNC	VGNC:79831
Canis familiaris	ZMAT3	VGNC	VGNC:48640
Felis catus	ZMAT3	VGNC	VGNC:67253
Rattus norvegicus	ZMAT3	RGD	RGD:620134

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