2. Gene
  3. ATG3 - autophagy related 3 Gene

ATG3 - autophagy related 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APG3; APG3L; hApg3; PC3-96; APG3-LIKE

Gene ID: 64422 | Gene type: protein coding

About ATG3

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,532,510-112,561,962 (from NCBI)

This gene has 9 transcripts (splice variants) and 220 orthologues. Ubiquitous expression in testis (RPKM 24.5), bone marrow (RPKM 17.6) and 25 other tissues.

Summary

This gene encodes a ubiquitin-like-conjugating Enzyme and is a component of ubiquitination-like systems involved in Autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of Autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

ATG3 Products(2)

mRNA Protein Name
NM_001278712.2 NP_001265641.1 ubiquitin-like-conjugating enzyme ATG3 isoform 2
NM_022488.5 NP_071933.2 ubiquitin-like-conjugating enzyme ATG3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables Atg8-family conjugating enzyme activity IDA
IDA: Inferred from direct assay
12207896 GOA
enables Atg8-family conjugating enzyme activity IMP
IMP: Inferred from mutant phenotype
24191030 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
11825910 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11825910 GOA
enables ubiquitin-like protein transferase activity IDA
IDA: Inferred from direct assay
11825910 GOA
Biological Process GO Annotation Evidence Reference Source
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
33446636 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
11825910 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Atg12-Atg5-Atg16 complex IDA
IDA: Inferred from direct assay
24186333 GOA
is active in cytoplasm IDA
IDA: Inferred from direct assay
11825910 GOA
located in cytosol IDA
IDA: Inferred from direct assay
11825910 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG3 Protein Structure

Autophagy_N

Autophagy_N: Autophagocytosis associated protein (Atg3), N-terminal domain (8 - 150)

Autophagy_act_C

Autophagy_act_C: Autophagocytosis associated protein, active-site domain (203 - 265)

Autophagy_C

Autophagy_C: Autophagocytosis associated protein C-terminal (286 - 310)

  • 0
  • 100
  • 200
  • 314 a.a.
Protein Preferred Names Protein Names

ubiquitin-like-conjugating enzyme ATG3

APG3 autophagy 3-like

ATG3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ATG3 Q9NT62 TECPR1 Homo sapiens Q7Z6L1
Anti Tag CoIP
20562859
Intra
ATG3 Q9NT62 GNB2 Homo sapiens P62879
Validated Y2H
32814053
Intra
ATG3 Q9NT62 GNB2 Homo sapiens P62879
Y2H Pooling
32814053
Intra
ATG3 Q9NT62 GNB2 Homo sapiens P62879
Y2H Array
32814053
Intra
ATG3 Q9NT62 MAP1LC3B Homo sapiens Q9GZQ8
Comig Non-Denat Gel
16303767
Intra
ATG3 Q9NT62 MAP1LC3B Homo sapiens Q9GZQ8
Pull Down
20562859
Intra
ATG3 Q9NT62 GABARAP Homo sapiens O95166
Anti Tag CoIP
20562859
Intra
ATG3 Q9NT62 GABARAP Homo sapiens O95166
Pull Down
20562859
Intra
ATG3 Q9NT62 GABARAPL2 Homo sapiens P60520
Anti Tag CoIP
33961781
Intra
ATG3 Q9NT62 GABARAPL2 Homo sapiens P60520
Pull Down
20562859
Intra
ATG3 Q9NT62 GABARAPL2 Homo sapiens P60520
Anti Tag CoIP
35271311
Intra
ATG3 Q9NT62 GABARAPL2 Homo sapiens P60520
Anti Tag CoIP
20562859
Intra
ATG3 Q9NT62 GABARAPL2 Homo sapiens P60520
Comig Non-Denat Gel
16303767
Intra
ATG3 Q9NT62 ATG12 Homo sapiens O94817
Anti Tag CoIP
20562859
Intra
ATG3 Q9NT62 ATG12 Homo sapiens O94817
Anti Tag CoIP
33961781
Intra
ATG3 Q9NT62 GABARAPL1 Homo sapiens Q9H0R8
Pull Down
20562859
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATG3 Proteins

Cat. No. Product Name Accession Purity
HY-P7617 ATG3 Protein, Human Q9NT62 (M1-M314) ≥95%

Related Diseases

Diseases Alias
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis

Acanthamoeba Encephalitis

Acanthamoeba Granulomatous Encephalitis

Granulomatous Amebic Encephalitis Due To Acanthamoeba
Primary Amebic Meningoencephalitis

Pam

Naegleria Fowleri Infection

Meningoencephalitis Caused By Naegleria Fowleri

Primary Amoebic Meningoencephalitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156966 ATG12-ATG3 inhibitor 1 Inhibitor 99.31% Unkown
HY-162932 ATG12-IN-1 Inhibitor / Unkown
HY-RS01147 ATG3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ATG3 VGNC VGNC:103660
Rattus norvegicus ATG3 RGD RGD:708464
Mus musculus ATG3 MGD MGI:1915091
Bos taurus ATG3 VGNC VGNC:26256
Macaca mulatta ATG3 VGNC VGNC:70105
Felis catus ATG3 VGNC VGNC:102599
Others ATG3 NCBI