FAM83G - family with sequence similarity 83 member G Gene

Homo sapiens

Also known as PAWS1

Gene ID: 644815 | Gene type: protein coding

About FAM83G

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:18,968,789-19,006,116 (from NCBI)

This gene has 4 transcripts (splice variants), 271 orthologues and 7 paralogues. Biased expression in skin (RPKM 27.6), esophagus (RPKM 12.8) and 13 other tissues.

Summary

Predicted to enable protein kinase binding activity. Involved in BMP signaling pathway. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

FAM83G Products(1)

mRNA	Protein	Name
NM_001039999.3	NP_001035088.2	protein FAM83G

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23455922	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	24554596	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	24554596	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24554596	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAM83G Protein Structure

DUF1669

0
200
400
600
823 a.a.

Protein Preferred Names

Protein Names

protein FAM83G

protein associated with SMAD1

FAM83G Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FAM83G	A6ND36	CSNK1A1	Homo sapiens	P48729	Protein Kinase Assay	29789297
Intra	FAM83G	A6ND36	CSNK1A1	Homo sapiens	P48729	Anti Tag CoIP	29789297

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Amelogenesis Imperfecta, Type Iiia

Ai3	Adhcai
Amelogenesis Imperfecta Type 3	AI3A
Amelogenesis Imperfecta, Type Iii	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant
Amelogenesis Imperfecta Type 3a	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iii	Hypocalcified Amelogenesis Imperfecta
Amelogenesis Imperfecta, Type 3	Amelogenesis Imperfecta, Hypomineralization Type
Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type	Amelogenesis Imperfecta 3a
Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04725	FAM83G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FAM83G	VGNC	VGNC:62133
Rattus norvegicus	FAM83G	RGD	RGD:2322345
Canis familiaris	FAM83G	VGNC	VGNC:40704
Macaca mulatta	FAM83G	VGNC	VGNC:99150
Bos taurus	FAM83G	VGNC	VGNC:28838
Mus musculus	FAM83G	MGD	MGI:1916890

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