MOSPD3 - motile sperm domain containing 3 Gene

Homo sapiens

Also known as CDS3; NET30

Gene ID: 64598 | Gene type: protein coding

About MOSPD3

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,612,162-100,615,377 (from NCBI)

This gene has 8 transcripts (splice variants) and 86 orthologues. Ubiquitous expression in testis (RPKM 10.0), adrenal (RPKM 6.8) and 25 other tissues.

Summary

This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described. [provided by RefSeq, Jul 2008]

MOSPD3 Products(6)

mRNA	Protein	Name
NM_001040097.2	NP_001035186.1	motile sperm domain-containing protein 3 isoform a
NM_001040098.1	NP_001035187.1	motile sperm domain-containing protein 3 isoform a
NM_001040099.2	NP_001035188.1	motile sperm domain-containing protein 3 isoform b
NM_001363415.1	NP_001350344.1	motile sperm domain-containing protein 3 isoform a
NM_001363416.1	NP_001350345.1	motile sperm domain-containing protein 3 isoform a
NM_023948.5	NP_076438.1	motile sperm domain-containing protein 3 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOSPD3 Protein Structure

Motile_Sperm

0
100
200
235 a.a.

Protein Preferred Names

Protein Names

motile sperm domain-containing protein 3

MOSPD3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MOSPD3	O75425	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	MOSPD3	O75425	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	MOSPD3	O75425	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	MOSPD3	O75425	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	MOSPD3	O75425	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	MOSPD3	O75425	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	MOSPD3	O75425	RILPL1	Homo sapiens	Q5EBL4-3	Y2H Array	32296183
Intra	MOSPD3	O75425	RILPL1	Homo sapiens	Q5EBL4-3	Validated Y2H	32296183
Intra	MOSPD3	O75425	RILPL1	Homo sapiens	Q5EBL4-3	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	MOSPD3	O75425	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	MOSPD3	O75425	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	MOSPD3	O75425	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	MOSPD3	O75425	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	MOSPD3	O75425	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	MOSPD3	O75425	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	MOSPD3	O75425	MILR1	Homo sapiens	Q7Z6M3	Y2H Array	32296183
Intra	MOSPD3	O75425	MILR1	Homo sapiens	Q7Z6M3	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	MILR1	Homo sapiens	Q7Z6M3	Validated Y2H	32296183
Intra	MOSPD3	O75425	ATP5PF	Homo sapiens	P18859	Y2H Array	32296183
Intra	MOSPD3	O75425	ATP5PF	Homo sapiens	P18859	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	ATP5PF	Homo sapiens	P18859	Validated Y2H	32296183
Intra	MOSPD3	O75425	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	MOSPD3	O75425	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	MOSPD3	O75425	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	IER3IP1	Homo sapiens	Q9Y5U9	Validated Y2H	32296183
Intra	MOSPD3	O75425	IER3IP1	Homo sapiens	Q9Y5U9	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	IER3IP1	Homo sapiens	Q9Y5U9	Y2H Array	32296183
Intra	MOSPD3	O75425	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	MOSPD3	O75425	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	MOSPD3	O75425	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	MOSPD3	O75425	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	MOSPD3	O75425	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	MOSPD3	O75425	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	MOSPD3	O75425	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
Intra	MOSPD3	O75425	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	MOSPD3	O75425	CD79A	Homo sapiens	P11912	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cyclosporiasis

Cyclosporosis

Cyclospora Infection

Lymphogranuloma Venereum

Climatic Or Tropical Bubo	Durand-Nicolas-Favre Disease
Lymphogranuloma Inguinale	Poradenitis Inguinale
Strumous Bubo	Lgv

Granuloma Inguinale

Donovanosis	Pudendal Ulcer
Granuloma Inguinale Tropicum	Granuloma Pudendi Tropicum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08602	MOSPD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MOSPD3	VGNC	VGNC:74823
Canis familiaris	MOSPD3	VGNC	VGNC:43326
Mus musculus	MOSPD3	MGD	MGI:1916179
Felis catus	MOSPD3	VGNC	VGNC:63567
Rattus norvegicus	MOSPD3	RGD	RGD:1304973
Bos taurus	MOSPD3	VGNC	VGNC:31565

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