2. Gene
  3. CSRNP1 - cysteine and serine rich nuclear protein 1 Gene

CSRNP1 - cysteine and serine rich nuclear protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as AXUD1; URAX1; TAIP-3; CSRNP-1; FAM130B

Gene ID: 64651 | Gene type: protein coding

About CSRNP1

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:39,141,855-39,154,641 (from NCBI)

This gene has 2 transcripts (splice variants), 260 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 36.5), gall bladder (RPKM 21.9) and 24 other tissues.

Summary

This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

CSRNP1 Products(3)

mRNA Protein Name
NM_001320559.2 NP_001307488.1 cysteine/serine-rich nuclear protein 1 isoform a
NM_001320560.2 NP_001307489.1 cysteine/serine-rich nuclear protein 1 isoform b
NM_033027.4 NP_149016.2 cysteine/serine-rich nuclear protein 1 isoform b
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22321011 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cysteine/serine-rich nuclear protein 1

AXIN1 up-regulated 1

CSRNP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CSRNP1 Q96S65 PRPF18 Homo sapiens Q99633
Validated Y2H
32296183
Intra
CSRNP1 Q96S65 MCRS1 Homo sapiens Q96EZ8
Anti Tag CoIP
33961781
Intra
CSRNP1 Q96S65 PPP1CB Homo sapiens P62140
Anti Tag CoIP
33961781
Intra
CSRNP1 Q96S65 PPP1CB Homo sapiens P62140
Validated Y2H
32296183
Intra
CSRNP1 Q96S65 PPP1CC Homo sapiens P36873
Y2H Array
25416956
Intra
CSRNP1 Q96S65 PPP1CC Homo sapiens P36873
Anti Tag CoIP
33961781
Intra
CSRNP1 Q96S65 PPP1CA Homo sapiens P62136
Validated Y2H
25416956
Intra
CSRNP1 Q96S65 PPP1CA Homo sapiens P62136
Y2H Array
25416956
Intra
CSRNP1 Q96S65 ZNF587 Homo sapiens Q96SQ5
Y2H Prey Pooling
25416956
Intra
CSRNP1 Q96S65 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
25416956
Intra
CSRNP1 Q96S65 ZNF587 Homo sapiens Q96SQ5
Y2H Array
25416956
Intra
CSRNP1 Q96S65 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
25416956
Intra
CSRNP1 Q96S65 AQP1 Homo sapiens P29972
Validated Y2H
25416956
Intra
CSRNP1 Q96S65 TCEANC Homo sapiens Q8N8B7
Validated Y2H
25416956
Intra
CSRNP1 Q96S65 TCEANC Homo sapiens Q8N8B7
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03257 CSRNP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CSRNP1 VGNC VGNC:27772
Mus musculus CSRNP1 MGD MGI:2387989
Canis familiaris CSRNP1 VGNC VGNC:39673
Rattus norvegicus CSRNP1 RGD RGD:1305999
Macaca mulatta CSRNP1 VGNC VGNC:71404
Felis catus CSRNP1 VGNC VGNC:61230