SMAP2 - small ArfGAP2 Gene

Homo sapiens

Also known as SMAP1L

Gene ID: 64744 | Gene type: protein coding

About SMAP2

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,344,834-40,423,326 (from NCBI)

This gene has 6 transcripts (splice variants), 186 orthologues and 28 paralogues. Broad expression in lymph node (RPKM 80.3), spleen (RPKM 58.9) and 23 other tissues.

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in regulation of catalytic activity. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SMAP2 Products(4)

mRNA	Protein	Name
NM_001198978.2	NP_001185907.1	stromal membrane-associated protein 2 isoform 3
NM_001198979.2	NP_001185908.1	stromal membrane-associated protein 2 isoform 2
NM_001198980.1	NP_001185909.1	stromal membrane-associated protein 2 isoform 4
NM_022733.3	NP_073570.1	stromal membrane-associated protein 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMAP2 Protein Structure

ArfGap

0
100
200
300
400
429 a.a.

Protein Preferred Names

Protein Names

stromal membrane-associated protein 2

stromal membrane-associated GTPase-activating protein 2

SMAP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SMAP2	Q8WU79	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	SMAP2	Q8WU79	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	SMAP2	Q8WU79	SMAP1	Homo sapiens	Q8IYB5-2	Y2H Array	32296183
Intra	SMAP2	Q8WU79	SMAP1	Homo sapiens	Q8IYB5-2	Y2H Prey Pooling	32296183
Intra	SMAP2	Q8WU79	MSX2	Homo sapiens	P35548	Y2H Array	32296183
Intra	SMAP2	Q8WU79	MSX2	Homo sapiens	P35548	Y2H Prey Pooling	32296183
Intra	SMAP2	Q8WU79	BHLHE40	Homo sapiens	O14503	Y2H Array	32296183
Intra	SMAP2	Q8WU79	BHLHE40	Homo sapiens	O14503	Y2H Prey Pooling	32296183
Intra	SMAP2	Q8WU79	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	25416956
Intra	SMAP2	Q8WU79	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
Intra	SMAP2	Q8WU79	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	25416956
Intra	SMAP2	Q8WU79	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	SMAP2	Q8WU79	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
Intra	SMAP2	Q8WU79	DAZAP2	Homo sapiens	Q15038	Y2H Array	25416956
Intra	SMAP2	Q8WU79	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	SMAP2	Q8WU79	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	25416956
Intra	SMAP2	Q8WU79	DAZAP2	Homo sapiens	Q15038	Validated Y2H	25416956
Intra	SMAP2	Q8WU79	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	SMAP2	Q8WU79	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183
Intra	SMAP2	Q8WU79	CRX	Homo sapiens	O43186	Y2H Array	32296183
Intra	SMAP2	Q8WU79	TENT5B	Homo sapiens	Q96A09	Validated Y2H	32296183
Intra	SMAP2	Q8WU79	TENT5B	Homo sapiens	Q96A09	Y2H Prey Pooling	32296183
Intra	SMAP2	Q8WU79	TENT5B	Homo sapiens	Q96A09	Y2H Array	32296183
Intra	SMAP2	Q8WU79	DAB1	Homo sapiens	O75553	Y2H Prey Pooling	25416956
Intra	SMAP2	Q8WU79	DAB1	Homo sapiens	O75553	Y2H Array	25416956
Intra	SMAP2	Q8WU79	FAM168A	Homo sapiens	Q92567	Y2H Prey Pooling	25416956
Intra	SMAP2	Q8WU79	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Kniest Dysplasia

Kniest Syndrome	Metatropic Dwarfism, Type Ii
Kniest Chondrodystrophy	Metatropic Dysplasia Type Ii
Swiss Cheese Cartilage Dysplasia	KD
Ks	Metatropic Dwarfism Type Ii
Dysplasia, Kniest

Vitreous Syneresis

Vitreous Degeneration

Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Marshall Syndrome

MRSHS	Deafness, Myopia, Cataract, Saddle Nose-Marshall Type
Periodic Fever, Aphthous Stomatitis, Pharyngitis And Adenitis	Pfapa Syndrome
Pfapa	Marshall Syndrome With Periodic Fever
Periodic Fever-Aphtous Stomatitis-Pharyngitis-Adenopathy Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120272	SMAP-2	Activator	99.63%	Unkown
HY-RS13402	SMAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SMAP2	VGNC	VGNC:65461
Canis familiaris	SMAP2	VGNC	VGNC:54223
Mus musculus	SMAP2	MGD	MGI:1917030
Macaca mulatta	SMAP2	VGNC	VGNC:77772
Rattus norvegicus	SMAP2	RGD	RGD:1308418
Bos taurus	SMAP2	VGNC	VGNC:34984

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