FAM168A - family with sequence similarity 168 member A Gene

Homo sapiens

Also known as TCRP1; KIAA0280

Gene ID: 23201 | Gene type: protein coding

About FAM168A

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:73,400,487-73,598,112 (from NCBI)

This gene has 5 transcripts (splice variants), 223 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 45.1), gall bladder (RPKM 10.1) and 24 other tissues.

Summary

Involved in positive regulation of base-excision repair. [provided by Alliance of Genome Resources, Apr 2022]

FAM168A Products(3)

mRNA	Protein	Name
NM_001286050.2	NP_001272979.1	protein FAM168A isoform 1
NM_001286051.2	NP_001272980.1	protein FAM168A isoform 3
NM_015159.3	NP_055974.1	protein FAM168A isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of base-excision repair	IDA IDA: Inferred from direct assay	25260657	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAM168A Protein Structure

TCRP1

0
100
200
244 a.a.

Protein Preferred Names

Protein Names

protein FAM168A

tongue cancer chemotherapy resistance-associated protein 1

FAM168A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FAM168A	Q92567	PRR20C	Homo sapiens	P86479	Y2H Prey Pooling	25416956
Intra	FAM168A	Q92567	SNRPC	Homo sapiens	Q5TAL4	Validated Y2H	25416956
Intra	FAM168A	Q92567	SNRPC	Homo sapiens	Q5TAL4	Y2H Array	25416956
Intra	FAM168A	Q92567	R3HDM2	Homo sapiens	Q9Y2K5-2	Y2H Prey Pooling	25416956
Intra	FAM168A	Q92567	R3HDM2	Homo sapiens	Q9Y2K5-2	Validated Y2H	25416956
Intra	FAM168A	Q92567	UBE2V1	Homo sapiens	Q13404	Validated Y2H	25416956
Intra	FAM168A	Q92567	UBASH3B	Homo sapiens	Q8TF42	Y2H Array	25416956
Intra	FAM168A	Q92567	UBASH3B	Homo sapiens	Q8TF42	Y2H Prey Pooling	25416956
Intra	FAM168A	Q92567	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	25416956
Intra	FAM168A	Q92567	NAF1	Homo sapiens	Q96HR8	Validated Y2H	25416956
Intra	FAM168A	Q92567	NAF1	Homo sapiens	Q96HR8	Y2H Array	25416956
Intra	FAM168A	Q92567	NAF1	Homo sapiens	Q96HR8	Y2H Prey Pooling	25416956
Intra	FAM168A	Q92567	VPS37C	Homo sapiens	A5D8V6	Validated Y2H	25416956
Intra	FAM168A	Q92567	SMAP2	Homo sapiens	Q8WU79	Validated Y2H	25416956
Intra	FAM168A	Q92567	SMAP2	Homo sapiens	Q8WU79	Y2H Array	25416956
Intra	FAM168A	Q92567	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	25416956
Intra	FAM168A	Q92567	DAZAP2	Homo sapiens	Q15038	Y2H Array	25416956
Intra	FAM168A	Q92567	KLHL42	Homo sapiens	Q9P2K6	Y2H Prey Pooling	25416956
Intra	FAM168A	Q92567	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	FAM168A	Q92567	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956
Intra	FAM168A	Q92567	RBPMS	Homo sapiens	Q93062	Y2H Prey Pooling	25416956
Intra	FAM168A	Q92567	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	25416956
Intra	FAM168A	Q92567	DTX2	Homo sapiens	Q86UW9	Validated Y2H	25416956
Intra	FAM168A	Q92567	DTX2	Homo sapiens	Q86UW9	Y2H Array	25416956
Intra	FAM168A	Q92567	SF1	Homo sapiens	Q15637	Y2H Prey Pooling	25416956
Intra	FAM168A	Q92567	SF1	Homo sapiens	Q15637	Validated Y2H	25416956
Intra	FAM168A	Q92567	SF1	Homo sapiens	Q15637	Y2H Array	25416956
Intra	FAM168A	Q92567	SS18L1	Homo sapiens	O75177	Y2H Prey Pooling	25416956
Intra	FAM168A	Q92567	SS18L1	Homo sapiens	O75177	Validated Y2H	25416956
Intra	FAM168A	Q92567	SS18L1	Homo sapiens	O75177	Y2H Array	25416956
Intra	FAM168A	Q92567	OTUB2	Homo sapiens	Q96DC9	Y2H Array	31515488
Intra	FAM168A	Q92567	OTUB2	Homo sapiens	Q96DC9	Y2H Array	25416956
Intra	FAM168A	Q92567	OTULIN	Homo sapiens	Q96BN8	Validated Y2H	25416956
Intra	FAM168A	Q92567	DAB1	Homo sapiens	O75553	Y2H Prey Pooling	25416956
Intra	FAM168A	Q92567	DAB1	Homo sapiens	O75553	Validated Y2H	25416956
Intra	FAM168A	Q92567	DAB1	Homo sapiens	O75553	Y2H Array	25416956
Intra	FAM168A	Q92567	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	25416956
Intra	FAM168A	Q92567	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Oral Squamous Cell Carcinoma

Mouth Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Mouth

Tongue Carcinoma

Tongue Cancer	Malignant Neoplasm Of Tongue
Tongue Neoplasms	Tongue Neoplasm

Deafness, Autosomal Recessive 63

DFNB63	Autosomal Recessive Nonsyndromic Deafness 63
Autosomal Recessive Deafness 63	Deafness, Autosomal Recessive, 63
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 63	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 63
Deafness, Autosomal Recessive, Type 63

Tongue Disease

Abnormality Of The Tongue	Tongue Diseases
Tongue Disorders	Disorder Of Tongue
Glossopathy	Unspecified Condition Of The Tongue

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04691	FAM168A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FAM168A	VGNC	VGNC:102881
Mus musculus	FAM168A	MGD	MGI:2442372
Canis familiaris	FAM168A	VGNC	VGNC:40619
Bos taurus	FAM168A	VGNC	VGNC:28752
Rattus norvegicus	FAM168A	RGD	RGD:1308929
Macaca mulatta	FAM168A	VGNC	VGNC:72398

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