SIAH2 - siah E3 ubiquitin protein ligase 2 Gene

Homo sapiens

Also known as hSiah2

Gene ID: 6478 | Gene type: protein coding

About SIAH2

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:150,741,125-150,763,169 (from NCBI)

This gene has 3 transcripts (splice variants), 198 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 42.6), placenta (RPKM 22.5) and 24 other tissues.

Summary

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 Ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin Ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]

SIAH2 Products(1)

mRNA	Protein	Name
NM_005067.7	NP_005058.3	E3 ubiquitin-protein ligase SIAH2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21586138	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	28546513	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21586138	GOA
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	12952940	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	21586138	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21586138	GOA
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	26392558	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	26392558	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21586138	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIAH2 Protein Structure

Sina

0
100
200
300
324 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase SIAH2

RING-type E3 ubiquitin transferase SIAH2

SIAH2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SIAH2	O43255	OPRM1	Homo sapiens	P35372	Y2H	23840749
Intra	SIAH2	O43255	SH3RF1	Homo sapiens	Q7Z6J0	Anti Tag CoIP	25438054
Intra	SIAH2	O43255	SH3RF1	Homo sapiens	Q7Z6J0	Y2H	21586138
Intra	SIAH2	O43255	LATS2	Homo sapiens	Q9NRM7	Pull Down	25438054
Intra	SIAH2	O43255	LATS2	Homo sapiens	Q9NRM7	Anti Tag CoIP	25438054
Intra	SIAH2	O43255	LATS1	Homo sapiens	O95835	Anti Tag CoIP	25438054

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Dyskeratosis Congenita, Autosomal Dominant 3

DKCA3	Autosomal Dominant Dyskeratosis Congenita 3
Dyskeratosis Congenita, Autosomal Dominant, 3	Dyskeratosis Congenita, Autosomal Dominant, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12892	SIAH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SIAH2	VGNC	VGNC:102843
Macaca mulatta	SIAH2	VGNC	VGNC:77215
Bos taurus	SIAH2	VGNC	VGNC:34614
Mus musculus	SIAH2	MGD	MGI:108062
Rattus norvegicus	SIAH2	RGD	RGD:620778

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