LATS2 - large tumor suppressor kinase 2 Gene

Homo sapiens

Also known as KPM

Gene ID: 26524 | Gene type: protein coding

About LATS2

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:20,973,036-21,061,586 (from NCBI)

This gene has 2 transcripts (splice variants), 212 orthologues, 13 paralogues and is associated with 97 phenotypes. Ubiquitous expression in testis (RPKM 10.9), gall bladder (RPKM 10.1) and 25 other tissues.

Summary

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to Cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

LATS2 Products(1)

mRNA	Protein	Name
NM_014572.3	NP_055387.2	serine/threonine-protein kinase LATS2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10871863	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16413547	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10871863	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	12853976	GOA
involved in hippo signaling	IDA IDA: Inferred from direct assay	20412773	GOA
involved in hormone-mediated signaling pathway	IDA IDA: Inferred from direct assay	15131260	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10871863	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12853976	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10871863	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	35429439	GOA
located in cytosol	IDA IDA: Inferred from direct assay	30865227	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10673337	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	12853976	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LATS2 Protein Structure

Pkinase

Pkinase_C

0
200
400
600
800
1000
1088 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase LATS2

LATS (large tumor suppressor, Drosophila) homolog 2

LATS2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LATS2	Q9NRM7	MOB1B	Homo sapiens	Q7L9L4	Anti Tag CoIP	19739119
Intra	LATS2	Q9NRM7	MOB1B	Homo sapiens	Q7L9L4	Pull Down	32707033
Intra	LATS2	Q9NRM7	MOB1B	Homo sapiens	Q7L9L4	Pull Down	19739119
Intra	LATS2	Q9NRM7	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	33961781
Intra	LATS2	Q9NRM7	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	19739119
Intra	LATS2	Q9NRM7	SIAH2	Homo sapiens	O43255	Anti Bait CoIP	25438054
Intra	LATS2	Q9NRM7	AJUBA	Homo sapiens	Q96IF1	Anti Tag CoIP	16413547

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Malignant Peritoneal Mesothelioma

Diffuse Malignant Peritoneal Mesothelioma	Primary Malignant Peritoneal Mesothelioma
Malignant Mesothelioma Of Peritoneum

Malignant Pleural Mesothelioma

Malignant Mesothelioma Of Pleura

Pleural Malignant Mesothelioma

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

Peritoneal Mesothelioma

Malignant Mesothelioma Of Peritoneum	Advanced Malignant Mesothelioma Of Peritoneum
Advanced Malignant Peritoneal Mesothelioma	Advanced Peritoneal Malignant Mesothelioma

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138489	TRULI	Modulator	99.98%	Unkown
HY-147082	GA-017	Activator	98.95%	Unkown
HY-147165	VT02956	Inhibitor	99.58%	Unkown
HY-130504	Propargyl-PEG1-acid		≥97.0%	Unkown
HY-RS07537	LAT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07539	LATS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-147165A	VT02956 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LATS2	VGNC	VGNC:82443
Canis familiaris	LATS2	VGNC	VGNC:42599
Rattus norvegicus	LATS2	RGD	RGD:1305906
Macaca mulatta	LATS2	VGNC	VGNC:74239
Mus musculus	LATS2	MGD	MGI:1354386
Bos taurus	LATS2	VGNC	VGNC:30801

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