LATS1 - large tumor suppressor kinase 1 Gene

Homo sapiens

Also known as wts; WARTS

Gene ID: 9113 | Gene type: protein coding

About LATS1

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,658,153-149,718,101 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues, 13 paralogues and is associated with 96 phenotypes. Ubiquitous expression in ovary (RPKM 6.7), endometrium (RPKM 5.8) and 25 other tissues.

Summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]

LATS1 Products(5)

mRNA	Protein	Name
NM_001270519.2	NP_001257448.1	serine/threonine-protein kinase LATS1 isoform 2
NM_001350339.2	NP_001337268.1	serine/threonine-protein kinase LATS1 isoform 3
NM_001350340.2	NP_001337269.1	serine/threonine-protein kinase LATS1 isoform 4
NM_001350392.2	NP_001337321.1	serine/threonine-protein kinase LATS1 isoform 5
NM_004690.4	NP_004681.1	serine/threonine-protein kinase LATS1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10518011	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	10518011	GOA
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	28068668	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9988268	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19927127	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10518011	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	15122335	GOA
involved in cytoplasmic sequestering of protein	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in hippo signaling	IDA IDA: Inferred from direct assay	20412773	GOA
involved in mammary gland epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	28068668	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9988268	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	20412773	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10518011	GOA
involved in regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	15220930	GOA
involved in regulation of intracellular estrogen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28068668	GOA
involved in regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	28068668	GOA
involved in sister chromatid segregation	IDA IDA: Inferred from direct assay	15122335	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	35429439	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	10518011	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LATS1 Protein Structure

UBA

Pkinase

0
200
400
600
800
1000
1130 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase LATS1

LATS (large tumor suppressor, Drosophila) homolog 1

LATS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LATS1	O95835	NF2	Homo sapiens	P35240	Anti Tag CoIP	24012335
Intra	LATS1	O95835	NF2	Homo sapiens	P35240	IF	24012335
Intra	LATS1	O95835	YAP1	Homo sapiens	P46937	ITC	25283809
Intra	LATS1	O95835	NUAK1	Homo sapiens	O60285	Anti Bait CoIP	19927127
Intra	LATS1	O95835	DCAF1	Homo sapiens	Q9Y4B6	Anti Tag CoIP	25026211
Intra	LATS1	O95835	MOB1B	Homo sapiens	Q7L9L4	Pull Down	19739119
Intra	LATS1	O95835	CDK2	Homo sapiens	P24941	Anti Bait CoIP	25218637
Intra	LATS1	O95835	ZYX	Homo sapiens	Q15942	CoIP	10831611
Intra	LATS1	O95835	ZYX	Homo sapiens	Q15942	Imaging	10831611
Intra	LATS1	O95835	ZYX	Homo sapiens	Q15942	Pull Down	10831611
Intra	LATS1	O95835	CDK1	Homo sapiens	P06493	Y2H	9988268
Intra	LATS1	O95835	CDK1	Homo sapiens	P06493	Anti Bait CoIP	25218637
Intra	LATS1	O95835	LIMK1	Homo sapiens	P53667	Pull Down	15220930
Intra	LATS1	O95835	LIMK1	Homo sapiens	P53667	CoIP	15220930
Intra	LATS1	O95835	WWTR1	Homo sapiens	Q9GZV5	Anti Bait CoIP	20412773
Intra	LATS1	O95835	WWTR1	Homo sapiens	Q9GZV5	Anti Bait CoIP	22078877
Intra	LATS1	O95835	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	19739119
Intra	LATS1	O95835	MOB1A	Homo sapiens	Q9H8S9	Pull Down	19739119
Intra	LATS1	O95835	ESR1	Homo sapiens	P03372	Anti Bait CoIP	28068668

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Malignant Peritoneal Mesothelioma

Diffuse Malignant Peritoneal Mesothelioma	Primary Malignant Peritoneal Mesothelioma
Malignant Mesothelioma Of Peritoneum

Tetraploidy

Tetraploidy Syndrome

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Microphthalmia, Syndromic 10

MCOPS10	Moba
Microphthalmia And Brain Atrophy	Syndromic Microphthalmia 10
Microphthalmia-Brain Atrophy Syndrome	Microphthalmia Syndromic 10
Moba Syndrome	Syndromic Microphthalmia Type 10

Metatypical Basal Cell Carcinoma

Skin Metatypical Carcinoma	Basosquamous Carcinoma Of Skin
Skin Metatypical Basal Cell Carcinoma

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Melanoma, Uveal

Uveal Melanoma	Choroidal Melanoma
Melanoma Of Uvea	Iris Melanoma
Malignant Melanoma Of Choroid	Malignant Melanoma Of Iris

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138489	TRULI	Modulator	99.98%	Unkown
HY-108540	BCH	Inducer	99.13%	Unkown
HY-147082	GA-017	Activator	98.95%	Unkown
HY-W011391	GPNA hydrochloride		99.91%	Unkown
HY-139330	MGH-CP1	Inducer	99.56%	Unkown
HY-147165	VT02956	Inhibitor	99.58%	Unkown
HY-120139	KMH-233	Inhibitor	98.11%	Unkown
HY-120139A	(R)-KMH-233		/	Unkown
HY-RS07538	LATS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-147165A	VT02956 hydrochloride	Inhibitor	/	Unkown
HY-164401	QBS10072S		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LATS1	VGNC	VGNC:74238
Felis catus	LATS1	VGNC	VGNC:68021
Canis familiaris	LATS1	VGNC	VGNC:42598
Bos taurus	LATS1	VGNC	VGNC:30800
Rattus norvegicus	LATS1	RGD	RGD:1564085
Mus musculus	LATS1	MGD	MGI:1333883
Others	LATS1	NCBI

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