YTHDC2 - YTH domain containing 2 Gene

Homo sapiens

Also known as CAHL; hYTHDC2

Gene ID: 64848 | Gene type: protein coding

About YTHDC2

Cytogenetic location: 5q22.2 Genomic coordinates (GRCh38): 5:113,513,694-113,595,284 (from NCBI)

This gene has 7 transcripts (splice variants), 209 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 9.0), lymph node (RPKM 7.1) and 25 other tissues.

Summary

This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic Cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver Cancer cell line. [provided by RefSeq, Sep 2016]

YTHDC2 Products(3)

mRNA	Protein	Name
NM_001345975.2	NP_001332904.1	3'-5' RNA helicase YTHDC2 isoform 2
NM_001345976.2	NP_001332905.1	3'-5' RNA helicase YTHDC2 isoform 3
NM_022828.5	NP_073739.3	3'-5' RNA helicase YTHDC2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5' RNA helicase activity	IDA IDA: Inferred from direct assay	29033321	GOA
enables ATP-dependent activity, acting on RNA	IDA IDA: Inferred from direct assay	21559518	GOA
enables N6-methyladenosine-containing RNA reader activity	IDA IDA: Inferred from direct assay	26318451	GOA
enables RNA polymerase binding	IPI IPI: Inferred from physical interaction	21559518	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation by host of viral genome replication	IMP IMP: Inferred from mutant phenotype	21559518	GOA
involved in response to interleukin-1	IDA IDA: Inferred from direct assay	21559518	GOA
involved in response to tumor necrosis factor	IDA IDA: Inferred from direct assay	21559518	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21559518	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YTHDC2 Protein Structure

R3H

DEAD

Ank_2

Helicase_C

HA2

OB_NTP_bind

YTH

0
300
600
900
1200
1430 a.a.

Protein Preferred Names

Protein Names

3'-5' RNA helicase YTHDC2

CsA-associated helicase-like protein

YTHDC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	YTHDC2	Q9H6S0	Meioc	Mus musculus	A2AG06	Anti Tag CoIP	26742488
Intra	YTHDC2	Q9H6S0	IRF4	Homo sapiens	Q15306	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15936	YTHDC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-168610	YTH-IN-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	YTHDC2	MGD	MGI:2448561
Canis familiaris	YTHDC2	VGNC	VGNC:48504
Rattus norvegicus	YTHDC2	RGD	RGD:1563192
Bos taurus	YTHDC2	VGNC	VGNC:37040
Macaca mulatta	YTHDC2	VGNC	VGNC:79452

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