NABP1 - nucleic acid binding protein 1 Gene

Homo sapiens

Also known as SSB2; OBFC2A; SOSS-B2; NABP1-OT1

Gene ID: 64859 | Gene type: protein coding

About NABP1

Cytogenetic location: 2q32.3 Genomic coordinates (GRCh38): 2:191,678,136-191,686,943 (from NCBI)

This gene has 16 transcripts (splice variants), 205 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in appendix (RPKM 17.5), spleen (RPKM 12.9) and 21 other tissues.

Summary

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

NABP1 Products(2)

mRNA	Protein	Name
NM_001031716.5	NP_001026886.1	SOSS complex subunit B2 isoform 1
NM_001254736.3	NP_001241665.1	SOSS complex subunit B2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19683501	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	19683501	GOA
involved in DNA repair	IMP IMP: Inferred from mutant phenotype	19683501	GOA
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	19683501	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	19605351	GOA
involved in mitotic G2/M transition checkpoint	IDA IDA: Inferred from direct assay	19683501	GOA
involved in mitotic G2/M transition checkpoint	IMP IMP: Inferred from mutant phenotype	19683501	GOA
involved in response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	19605351	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SOSS complex	IDA IDA: Inferred from direct assay	18449195	GOA
part of SOSS complex	IPI IPI: Inferred from physical interaction	19683501	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19683501	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	19683501	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NABP1 Protein Structure

tRNA_anti-codon

0
100
204 a.a.

Protein Preferred Names

Protein Names

SOSS complex subunit B2

NABP1 3'UTR overlapping transcript 1

NABP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NABP1	Q96AH0	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	NABP1	Q96AH0	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	NABP1	Q96AH0	MKRN3	Homo sapiens	Q13064	Validated Y2H	25416956
Intra	NABP1	Q96AH0	INTS3	Homo sapiens	Q68E01	Anti Bait CoIP	19683501
Intra	NABP1	Q96AH0	INTS3	Homo sapiens	Q68E01	Pull Down	19683501
Intra	NABP1	Q96AH0	TRIM7	Homo sapiens	Q9C029	Validated Y2H	32296183
Intra	NABP1	Q96AH0	TRIM7	Homo sapiens	Q9C029	Y2H Prey Pooling	32296183
Intra	NABP1	Q96AH0	TRIM7	Homo sapiens	Q9C029	Y2H Array	32296183
Intra	NABP1	Q96AH0	PURB	Homo sapiens	Q96QR8	Validated Y2H	32296183
Intra	NABP1	Q96AH0	PURB	Homo sapiens	Q96QR8	Y2H Array	32296183
Intra	NABP1	Q96AH0	PURB	Homo sapiens	Q96QR8	Y2H Prey Pooling	32296183
Intra	NABP1	Q96AH0	COPS3	Homo sapiens	Q9UNS2	Validated Y2H	32296183
Intra	NABP1	Q96AH0	COPS3	Homo sapiens	Q9UNS2	Y2H Prey Pooling	32296183
Intra	NABP1	Q96AH0	COPS3	Homo sapiens	Q9UNS2	Y2H Array	32296183
Intra	NABP1	Q96AH0	TFCP2	Homo sapiens	Q12800	Y2H Array	25416956
Intra	NABP1	Q96AH0	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	25416956
Intra	NABP1	Q96AH0	RBMX	Homo sapiens	P38159	Y2H Array	25416956
Intra	NABP1	Q96AH0	RBMX	Homo sapiens	P38159	Y2H Array	32296183
Intra	NABP1	Q96AH0	RBMX	Homo sapiens	P38159	Y2H Prey Pooling	25416956
Intra	NABP1	Q96AH0	RBMX	Homo sapiens	P38159	Validated Y2H	25416956
Intra	NABP1	Q96AH0	RBMX	Homo sapiens	P38159	Y2H Prey Pooling	32296183
Intra	NABP1	Q96AH0	QKI	Homo sapiens	Q96PU8	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Cholestasis, Intrahepatic, Of Pregnancy 3

ICP3	Cholestasis, Intrahepatic, Of Pregnancy, 3
Intrahepatic Cholestasis Of Pregnancy 3	Pregnancy Related Cholestasis 3
Cholestasis Of Pregnancy, Intrahepatic 3	Cholestasis, Intrahepatic, Of Pregnancy, Type 3

Splenic Manifestation Of Leukemia

Splenic Leukemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08998	NABP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NABP1	RGD	RGD:1306658
Bos taurus	NABP1	VGNC	VGNC:31859
Mus musculus	NABP1	MGD	MGI:1923258
Felis catus	NABP1	VGNC	VGNC:63706
Macaca mulatta	NABP1	VGNC	VGNC:75025

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