2. Gene
  3. BNIP1 - BCL2 interacting protein 1 Gene

BNIP1 - BCL2 interacting protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NIP1; SEC20; TRG-8

Gene ID: 662 | Gene type: protein coding

About BNIP1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:173,144,531-173,164,387 (from NCBI)

This gene has 5 transcripts (splice variants) and 276 orthologues. Ubiquitous expression in bone marrow (RPKM 8.6), testis (RPKM 6.9) and 25 other tissues.

Summary

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]

BNIP1 Products(4)

mRNA Protein Name
NM_001205.3 NP_001196.2 vesicle transport protein SEC20 isoform BNIP1
NM_013978.3 NP_053581.2 vesicle transport protein SEC20 isoform BNIP1-a
NM_013979.3 NP_053582.2 vesicle transport protein SEC20 isoform BNIP1-b
NM_013980.3 NP_053583.2 vesicle transport protein SEC20 isoform BNIP1-c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SNAP receptor activity IDA
IDA: Inferred from direct assay
15272311 GOA
enables calcium-induced calcium release activity IDA
IDA: Inferred from direct assay
29222049 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7954800 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within apoptotic process IPI
IPI: Inferred from physical interaction
7954800 GOA
involved in apoptotic process in response to mitochondrial fragmentation IDA
IDA: Inferred from direct assay
29222049 GOA
involved in endoplasmic reticulum membrane fusion IMP
IMP: Inferred from mutant phenotype
15272311 GOA
involved in endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
15272311 GOA
Cellular Component GO Annotation Evidence Reference Source
part of SNARE complex IDA
IDA: Inferred from direct assay
15272311 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
7954800 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15272311 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
23896122 GOA
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
7954800 GOA
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
21931693 GOA
is active in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
23896122 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
7954800 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BNIP1 Protein Structure

Sec20

Sec20: Sec20 (134 - 224)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

vesicle transport protein SEC20

BCL2/adenovirus E1B 19 kDa protein-interacting protein 1

BNIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BNIP1 Q12981 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
BNIP1 Q12981 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
BNIP1 Q12981 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
BNIP1 Q12981 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
BNIP1 Q12981 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
BNIP1 Q12981 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
BNIP1 Q12981 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
BNIP1 Q12981 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
BNIP1 Q12981 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra
BNIP1 Q12981 VMA21 Homo sapiens Q3ZAQ7
Y2H Array
32296183
Intra
BNIP1 Q12981 VMA21 Homo sapiens Q3ZAQ7
Validated Y2H
32296183
Intra
BNIP1 Q12981 VMA21 Homo sapiens Q3ZAQ7
Y2H Prey Pooling
32296183
Intra
BNIP1 Q12981 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
BNIP1 Q12981 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
BNIP1 Q12981 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
BNIP1 Q12981 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
BNIP1 Q12981 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
BNIP1 Q12981 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
BNIP1 Q12981 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
BNIP1 Q12981 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra
BNIP1 Q12981 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra
BNIP1 Q12981 FAM174A Homo sapiens Q8TBP5
Validated Y2H
32296183
Intra
BNIP1 Q12981 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra
BNIP1 Q12981 MARCHF5 Homo sapiens Q9NX47
Validated Y2H
32296183
Intra
BNIP1 Q12981 SLC7A14 Homo sapiens Q8TBB6
Validated Y2H
32296183
Intra
BNIP1 Q12981 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
Intra
BNIP1 Q12981 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
Intra
BNIP1 Q12981 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
BNIP1 Q12981 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
BNIP1 Q12981 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
BNIP1 Q12981 TM4SF19 Homo sapiens Q96DZ7
Y2H Array
32296183
Intra
BNIP1 Q12981 TM4SF19 Homo sapiens Q96DZ7
Y2H Prey Pooling
32296183
Intra
BNIP1 Q12981 TM4SF19 Homo sapiens Q96DZ7
Validated Y2H
32296183
Intra
BNIP1 Q12981 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
BNIP1 Q12981 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra
BNIP1 Q12981 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
BNIP1 Q12981 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra
BNIP1 Q12981 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

BNIP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83584 BNIP1 Antibody (YA3329) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Pyloric Stenosis
Smith-Mccort Dysplasia 1

Smith-Mccort Dysplasia

SMC1

Smc

Smith Mccort Dysplasia

Smith-Mccort Dwarfism
Dyggve-Melchior-Clausen Disease

Dyggve-Melchior-Clausen Syndrome

DMC

Dmc Disease

Pseudo-Morquio Disease Type I

Dmc Syndrome
Fumarase Deficiency

Fumaric Aciduria

FMRD

Fumarate Hydratase Deficiency

Deficiency, Fumarase
Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder

Infantile Refsum Disease

Infantile Phytanic Acid Storage Disease

PBD1B

Refsum Disease, Infantile

Adrenoleukodystrophy, Autosomal Neonatal

Ird

Mild Pbd-Zsd

Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Pbd-Zsd

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Autosomal Neonatal Adrenoleukodystrophy

Refsum Disease Infantile

Peroxisome Biogenesis Disorders

Peroxisome Biogenesis Disorder, Type 1b
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01562 BNIP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BNIP1 MGD MGI:109328
Canis familiaris BNIP1 VGNC VGNC:38492
Macaca mulatta BNIP1 VGNC VGNC:70271
Rattus norvegicus BNIP1 RGD RGD:620799
Felis catus BNIP1 VGNC VGNC:60143
Bos taurus BNIP1 VGNC VGNC:26531