2. Gene
  3. CYB561 - cytochrome b561 Gene

CYB561 - cytochrome b561 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FRRS2; ORTHYP2; CYB561A1

Gene ID: 1534 | Gene type: protein coding

About CYB561

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,432,304-63,446,639 (from NCBI)

This gene has 21 transcripts (splice variants), 199 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in adrenal (RPKM 53.1), prostate (RPKM 31.9) and 23 other tissues.

Summary

Predicted to enable transmembrane monodehydroascorbate reductase activity. Predicted to be involved in ascorbate homeostasis. Predicted to be located in chromaffin granule membrane. Predicted to be active in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

CYB561 Products(4)

mRNA Protein Name
NM_001017916.2 NP_001017916.1 transmembrane ascorbate-dependent reductase CYB561 isoform 1
NM_001017917.2 NP_001017917.1 transmembrane ascorbate-dependent reductase CYB561 isoform 1
NM_001330421.2 NP_001317350.1 transmembrane ascorbate-dependent reductase CYB561 isoform 2
NM_001915.4 NP_001906.3 transmembrane ascorbate-dependent reductase CYB561 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYB561 Protein Structure

Cytochrom_B561

Cytochrom_B561: Eukaryotic cytochrome b561 (53 - 185)

  • 0
  • 100
  • 200
  • 251 a.a.
Protein Preferred Names Protein Names

transmembrane ascorbate-dependent reductase CYB561

cytochrome b-561

CYB561 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CYB561 P49447 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra CYB561 P49447 SLC38A7 Homo sapiens Q9NVC3
Y2H Array
32296183
Intra CYB561 P49447 SLC38A7 Homo sapiens Q9NVC3
Y2H Prey Pooling
32296183
Intra CYB561 P49447 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra CYB561 P49447 SYNJ2BP Homo sapiens P57105
Validated Y2H
32296183
Intra CYB561 P49447 GGT7 Homo sapiens Q9UJ14
Y2H Prey Pooling
32296183
Intra CYB561 P49447 GGT7 Homo sapiens Q9UJ14
Validated Y2H
32296183
Intra CYB561 P49447 GGT7 Homo sapiens Q9UJ14
Y2H Array
32296183
Intra CYB561 P49447 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
Intra CYB561 P49447 TMEM128 Homo sapiens Q5BJH2-2
Validated Y2H
32296183
Intra CYB561 P49447 ORMDL2 Homo sapiens Q53FV1
Validated Y2H
32296183
Intra CYB561 P49447 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra CYB561 P49447 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra CYB561 P49447 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra CYB561 P49447 TMEM179B Homo sapiens Q7Z7N9
Y2H Prey Pooling
32296183
Intra CYB561 P49447 TMEM179B Homo sapiens Q7Z7N9
Validated Y2H
32296183
Intra CYB561 P49447 TMEM179B Homo sapiens Q7Z7N9
Y2H Array
32296183
Intra CYB561 P49447 TMPPE Homo sapiens Q6ZT21
Validated Y2H
32296183
Intra CYB561 P49447 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra CYB561 P49447 ANKRD46 Homo sapiens Q86W74-2
Validated Y2H
32296183
Intra CYB561 P49447 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra CYB561 P49447 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra CYB561 P49447 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra CYB561 P49447 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra CYB561 P49447 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra CYB561 P49447 ZDHHC7 Homo sapiens Q9NXF8-2
Y2H Prey Pooling
32296183
Intra CYB561 P49447 ZDHHC7 Homo sapiens Q9NXF8-2
Validated Y2H
32296183
Intra CYB561 P49447 ZDHHC7 Homo sapiens Q9NXF8-2
Y2H Array
32296183
Intra CYB561 P49447 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra CYB561 P49447 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra CYB561 P49447 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra CYB561 P49447 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra CYB561 P49447 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra CYB561 P49447 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra CYB561 P49447 TM4SF18 Homo sapiens Q96CE8
Y2H Prey Pooling
32296183
Intra CYB561 P49447 TM4SF18 Homo sapiens Q96CE8
Validated Y2H
32296183
Intra CYB561 P49447 TM4SF18 Homo sapiens Q96CE8
Y2H Array
32296183
Intra CYB561 P49447 STX3 Homo sapiens Q13277
Validated Y2H
32296183
Intra CYB561 P49447 REEP6 Homo sapiens Q96HR9-2
Validated Y2H
32296183
Intra CYB561 P49447 TREX1 Homo sapiens Q9NSU2-1
Validated Y2H
32296183
Intra CYB561 P49447 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra CYB561 P49447 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra CYB561 P49447 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra CYB561 P49447 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra CYB561 P49447 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra CYB561 P49447 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra CYB561 P49447 EFNA5 Homo sapiens P52803
Y2H Prey Pooling
32296183
Intra CYB561 P49447 EFNA5 Homo sapiens P52803
Validated Y2H
32296183
Intra CYB561 P49447 EFNA5 Homo sapiens P52803
Y2H Array
32296183
Intra CYB561 P49447 CLDN9 Homo sapiens O95484
Y2H Array
32296183
Intra CYB561 P49447 CLDN9 Homo sapiens O95484
Y2H Prey Pooling
32296183
Intra CYB561 P49447 BEST2 Homo sapiens Q8NFU1
Validated Y2H
32296183
Intra CYB561 P49447 BEST2 Homo sapiens Q8NFU1
Y2H Array
32296183
Intra CYB561 P49447 BEST2 Homo sapiens Q8NFU1
Y2H Prey Pooling
32296183
Intra CYB561 P49447 EHHADH Homo sapiens Q08426
Validated Y2H
32296183
Intra CYB561 P49447 CMTM2 Homo sapiens Q8TAZ6
Y2H Prey Pooling
32296183
Intra CYB561 P49447 CMTM2 Homo sapiens Q8TAZ6
Validated Y2H
32296183
Intra CYB561 P49447 CMTM2 Homo sapiens Q8TAZ6
Y2H Array
32296183
Intra CYB561 P49447 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra CYB561 P49447 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra CYB561 P49447 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra CYB561 P49447 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra CYB561 P49447 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra CYB561 P49447 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra CYB561 P49447 DARS2 Homo sapiens Q6PI48
Y2H Prey Pooling
32296183
Intra CYB561 P49447 DARS2 Homo sapiens Q6PI48
Validated Y2H
32296183
Intra CYB561 P49447 DARS2 Homo sapiens Q6PI48
Y2H Array
32296183
Intra CYB561 P49447 SLC19A3 Homo sapiens Q9BZV2
Y2H Prey Pooling
32296183
Intra CYB561 P49447 SLC19A3 Homo sapiens Q9BZV2
Validated Y2H
32296183
Intra CYB561 P49447 SLC19A3 Homo sapiens Q9BZV2
Y2H Array
32296183
Intra CYB561 P49447 BNIP1 Homo sapiens Q12981
Validated Y2H
32296183
Intra CYB561 P49447 EDA Homo sapiens Q92838
Y2H Array
32296183
Intra CYB561 P49447 EDA Homo sapiens Q92838
Validated Y2H
25416956
Intra CYB561 P49447 EDA Homo sapiens Q92838
Y2H Prey Pooling
32296183
Intra CYB561 P49447 EDA Homo sapiens Q92838
Validated Y2H
32296183
Intra CYB561 P49447 EDA Homo sapiens Q92838
Y2H Array
25416956
Intra CYB561 P49447 PLP2 Homo sapiens Q04941
Validated Y2H
32296183
Intra CYB561 P49447 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
Intra CYB561 P49447 TMEM65 Homo sapiens Q6PI78
Validated Y2H
32296183
Intra CYB561 P49447 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra CYB561 P49447 BIK Homo sapiens Q13323
Validated Y2H
32296183
Intra CYB561 P49447 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra CYB561 P49447 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra CYB561 P49447 FKBP8 Homo sapiens Q14318
Validated Y2H
32296183
Intra CYB561 P49447 SLC39A1 Homo sapiens Q9NY26
Validated Y2H
32296183
Intra CYB561 P49447 SLC39A1 Homo sapiens Q9NY26
Y2H Array
32296183
Intra CYB561 P49447 SLC39A1 Homo sapiens Q9NY26
Y2H Prey Pooling
32296183
Intra CYB561 P49447 SERP2 Homo sapiens Q8N6R1
Validated Y2H
32296183
Intra CYB561 P49447 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra CYB561 P49447 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra CYB561 P49447 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra CYB561 P49447 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra CYB561 P49447 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra CYB561 P49447 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra CYB561 P49447 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra CYB561 P49447 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra CYB561 P49447 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Intra CYB561 P49447 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Orthostatic Hypotension 2

ORTHYP2
Dopamine Beta-Hydroxylase Deficiency

Noradrenaline Deficiency

Norepinephrine Deficiency

Dopamine Beta Hydroxylase Deficiency

Congenital Dopamine Beta-Hydroxylase Deficiency

Dopamine Beta-Hydroxylase Deficiency, Congenital

Dopamine Β-Hydroxylase

Dbh Deficiency
Glycogen Storage Disease Ixd

GSD9D

Gsd Ixd

Muscle Phosphorylase Kinase Deficiency

Muscle Glycogenosis

Glycogen Storage Disease Due To Muscle Phosphorylase Kinase Deficiency

Glycogen Storage Disease Type 9d

Glycogen Storage Disease Type 9e

Glycogen Storage Disease Type Ixd

Glycogen Storage Disease Type Ixe

Glycogenosis Due To Muscle Phosphorylase Kinase Deficiency

Glycogenosis Type 9d

Glycogenosis Type 9e

Glycogenosis Type Ixd

Glycogenosis Type Ixe

Gsd Due To Muscle Phosphorylase Kinase Deficiency

Gsd Type 9d

Gsd Type 9e

Gsd Type Ixd

Gsd Type Ixe

Muscle Glycogenosis, X-Linked

X-Linked Muscke Glycogenosis

Glycogen Storage Disease 9d

X-Linked Muscle Glycogenosis

Storage Disease, Glycogen, Type Ixd
Corticosteroid-Binding Globulin Deficiency

CBG DEFICIENCY

Transcortin Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03416 CYB561 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CYB561 MGD MGI:103253
Rattus norvegicus CYB561 RGD RGD:1310987
Macaca mulatta CYB561 VGNC VGNC:71574
Canis familiaris CYB561 VGNC VGNC:49089
Felis catus CYB561 VGNC VGNC:61306
Bos taurus CYB561 VGNC VGNC:50257