2. Gene
  3. PLP2 - proteolipid protein 2 Gene

PLP2 - proteolipid protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as A4; A4LSB

Gene ID: 5355 | Gene type: protein coding

About PLP2

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:49,171,898-49,175,235 (from NCBI)

This gene has 2 transcripts (splice variants), 233 orthologues and 14 paralogues. Ubiquitous expression in skin (RPKM 154.7), esophagus (RPKM 126.0) and 23 other tissues.

Summary

This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]

PLP2 Products(1)

mRNA Protein Name
NM_002668.3 NP_002659.1 proteolipid protein 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chemokine binding IPI
IPI: Inferred from physical interaction
15474493 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15474493 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
15474493 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLP2 Protein Structure

MARVEL

MARVEL: Membrane-associating domain (21 - 130)

  • 0
  • 100
  • 152 a.a.
Protein Preferred Names Protein Names

proteolipid protein 2

A4 differentiation-dependent protein

PLP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PLP2 Q04941 SPN Homo sapiens P16150
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 SPN Homo sapiens P16150
Y2H Array
32296183
Intra
PLP2 Q04941 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
PLP2 Q04941 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
PLP2 Q04941 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra
PLP2 Q04941 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
PLP2 Q04941 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra
PLP2 Q04941 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 ELOVL5 Homo sapiens Q9NYP7
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 ELOVL5 Homo sapiens Q9NYP7
Validated Y2H
32296183
Intra
PLP2 Q04941 ELOVL5 Homo sapiens Q9NYP7
Y2H Array
32296183
Intra
PLP2 Q04941 PTGES Homo sapiens O14684
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 PTGES Homo sapiens O14684
Y2H Array
32296183
Intra
PLP2 Q04941 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
PLP2 Q04941 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
PLP2 Q04941 GPR151 Homo sapiens Q8TDV0
Y2H Array
32296183
Intra
PLP2 Q04941 GPR151 Homo sapiens Q8TDV0
Validated Y2H
32296183
Intra
PLP2 Q04941 GPR151 Homo sapiens Q8TDV0
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra
PLP2 Q04941 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
PLP2 Q04941 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
PLP2 Q04941 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
PLP2 Q04941 ASGR2 Homo sapiens P07307-3
Y2H Array
32296183
Intra
PLP2 Q04941 ASGR2 Homo sapiens P07307-3
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 SLC14A2 Homo sapiens Q15849
Y2H Array
32296183
Intra
PLP2 Q04941 SLC14A2 Homo sapiens Q15849
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 SLC14A2 Homo sapiens Q15849
Validated Y2H
32296183
Intra
PLP2 Q04941 CRB3 Homo sapiens Q9BUF7-2
Y2H Array
32296183
Intra
PLP2 Q04941 CRB3 Homo sapiens Q9BUF7-2
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 CRB3 Homo sapiens Q9BUF7-2
Validated Y2H
32296183
Intra
PLP2 Q04941 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
PLP2 Q04941 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
PLP2 Q04941 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
PLP2 Q04941 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
PLP2 Q04941 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
PLP2 Q04941 PIGP Homo sapiens P57054
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 PIGP Homo sapiens P57054
Y2H Array
32296183
Intra
PLP2 Q04941 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
PLP2 Q04941 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
PLP2 Q04941 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
PLP2 Q04941 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
PLP2 Q04941 SLC2A13 Homo sapiens Q96QE2
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 SLC2A13 Homo sapiens Q96QE2
Validated Y2H
32296183
Intra
PLP2 Q04941 SLC2A13 Homo sapiens Q96QE2
Y2H Array
32296183
Intra
PLP2 Q04941 LHFPL1 Homo sapiens Q86WI0
Validated Y2H
32296183
Intra
PLP2 Q04941 LHFPL1 Homo sapiens Q86WI0
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 LHFPL1 Homo sapiens Q86WI0
Y2H Array
32296183
Intra
PLP2 Q04941 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
PLP2 Q04941 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
PLP2 Q04941 CLDN5 Homo sapiens O00501
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 CLDN5 Homo sapiens O00501
Y2H Array
32296183
Intra
PLP2 Q04941 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
PLP2 Q04941 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
PLP2 Q04941 AQP8 Homo sapiens O94778
Y2H Array
32296183
Intra
PLP2 Q04941 AQP8 Homo sapiens O94778
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 ATP5PF Homo sapiens P18859
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 ATP5PF Homo sapiens P18859
Y2H Array
32296183
Intra
PLP2 Q04941 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra
PLP2 Q04941 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra
PLP2 Q04941 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 CYBC1 Homo sapiens Q9BQA9
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra
PLP2 Q04941 CYBC1 Homo sapiens Q9BQA9
Y2H Array
32296183
Intra
PLP2 Q04941 AQP3 Homo sapiens Q92482
Validated Y2H
32296183
Intra
PLP2 Q04941 AQP3 Homo sapiens Q92482
Y2H Array
32296183
Intra
PLP2 Q04941 AQP3 Homo sapiens Q92482
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
PLP2 Q04941 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
PLP2 Q04941 EVI2A Homo sapiens P22794
Y2H Array
32296183
Intra
PLP2 Q04941 EVI2A Homo sapiens P22794
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 DNAJC1 Homo sapiens Q96KC8
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 DNAJC1 Homo sapiens Q96KC8
Validated Y2H
32296183
Intra
PLP2 Q04941 DNAJC1 Homo sapiens Q96KC8
Y2H Array
32296183
Intra
PLP2 Q04941 RNF5 Homo sapiens Q99942
Validated Y2H
32296183
Intra
PLP2 Q04941 RNF5 Homo sapiens Q99942
Y2H Array
32296183
Intra
PLP2 Q04941 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
PLP2 Q04941 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
PLP2 Q04941 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 DARS2 Homo sapiens Q6PI48
Validated Y2H
32296183
Intra
PLP2 Q04941 DARS2 Homo sapiens Q6PI48
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 DARS2 Homo sapiens Q6PI48
Y2H Array
32296183
Intra
PLP2 Q04941 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 PVR Homo sapiens P15151
Y2H Array
32296183
Intra
PLP2 Q04941 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
PLP2 Q04941 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
PLP2 Q04941 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 LRRC4C Homo sapiens Q9HCJ2
Validated Y2H
32296183
Intra
PLP2 Q04941 LRRC4C Homo sapiens Q9HCJ2
Y2H Array
32296183
Intra
PLP2 Q04941 LRRC4C Homo sapiens Q9HCJ2
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 PACC1 Homo sapiens Q9H813
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 PACC1 Homo sapiens Q9H813
Validated Y2H
32296183
Intra
PLP2 Q04941 PACC1 Homo sapiens Q9H813
Y2H Array
32296183
Intra
PLP2 Q04941 CCR1 Homo sapiens P32246
Anti Tag CoIP
15474493
Intra
PLP2 Q04941 CCR1 Homo sapiens P32246
Y2H
15474493
Intra
PLP2 Q04941 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
PLP2 Q04941 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
PLP2 Q04941 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 TM4SF19 Homo sapiens Q96DZ7
Validated Y2H
32296183
Intra
PLP2 Q04941 TM4SF19 Homo sapiens Q96DZ7
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 TM4SF19 Homo sapiens Q96DZ7
Y2H Array
32296183
Intra
PLP2 Q04941 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra
PLP2 Q04941 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
PLP2 Q04941 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
PLP2 Q04941 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 BIK Homo sapiens Q13323
Validated Y2H
32296183
Intra
PLP2 Q04941 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
PLP2 Q04941 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 PDZK1IP1 Homo sapiens Q13113
Validated Y2H
32296183
Intra
PLP2 Q04941 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
PLP2 Q04941 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
PLP2 Q04941 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 TMEM51 Homo sapiens Q9NW97
Validated Y2H
32296183
Intra
PLP2 Q04941 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra
PLP2 Q04941 THAP4 Homo sapiens Q8WY91
Validated Y2H
32296183
Intra
PLP2 Q04941 THAP4 Homo sapiens Q8WY91
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 THAP4 Homo sapiens Q8WY91
Y2H Array
32296183
Intra
PLP2 Q04941 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
PLP2 Q04941 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
Intra
PLP2 Q04941 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra
PLP2 Q04941 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
25416956
Intra
PLP2 Q04941 BNIP3 Homo sapiens Q12983
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 BNIP3 Homo sapiens Q12983
Validated Y2H
32296183
Intra
PLP2 Q04941 BNIP3 Homo sapiens Q12983
Y2H Array
32296183
Intra
PLP2 Q04941 CIAO2A Homo sapiens Q9H5X1
Validated Y2H
32296183
Intra
PLP2 Q04941 CIAO2A Homo sapiens Q9H5X1
Y2H Array
32296183
Intra
PLP2 Q04941 CIAO2A Homo sapiens Q9H5X1
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
PLP2 Q04941 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
PLP2 Q04941 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
PLP2 Q04941 CYBRD1 Homo sapiens Q53TN4
Y2H Array
32296183
Intra
PLP2 Q04941 CYBRD1 Homo sapiens Q53TN4
Validated Y2H
32296183
Intra
PLP2 Q04941 CYBRD1 Homo sapiens Q53TN4
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
PLP2 Q04941 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
PLP2 Q04941 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra
PLP2 Q04941 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra
PLP2 Q04941 TMEM79 Homo sapiens Q9BSE2
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Croup

Acute Obstructive Laryngitis

Laryngotracheobronchitis

Acute Laryngotracheobronchitis

Croup Syndrome

Acute Laryngitis With Obstruction

Obstructive Laryngitis

Obstructive Laryngitis Nos

Obstructive Laryngotracheitis Nos
Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P2296 Abz-FRLKGGAPIKGV-EDDNP TFA / Unkown
HY-RS10732 PLP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PLP2 VGNC VGNC:56949
Mus musculus PLP2 MGD MGI:1298382
Felis catus PLP2 VGNC VGNC:101462
Rattus norvegicus PLP2 RGD RGD:1587363
Macaca mulatta PLP2 VGNC VGNC:76179