STAC - SH3 and cysteine rich domain Gene

Homo sapiens

Also known as STAC1

Gene ID: 6769 | Gene type: protein coding

About STAC

Cytogenetic location: 3p22.3-p22.2 Genomic coordinates (GRCh38): 3:36,380,504-36,548,007 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and 2 paralogues. Biased expression in prostate (RPKM 5.7), lung (RPKM 4.4) and 11 other tissues.

Summary

Predicted to enable transmembrane transporter binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane; positive regulation of voltage-gated Calcium Channel activity; and skeletal muscle contraction. Predicted to act upstream of or within cellular response to heat; muscle contraction; and regulation of voltage-gated Calcium Channel activity. Predicted to be located in T-tubule. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

STAC Products(2)

mRNA	Protein	Name
NM_001292049.2	NP_001278978.1	SH3 and cysteine-rich domain-containing protein isoform 2
NM_003149.3	NP_003140.1	SH3 and cysteine-rich domain-containing protein isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16260042	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAC Protein Structure

C1_1

SH3_1

SH3_2

0
100
200
300
402 a.a.

Protein Preferred Names

Protein Names

SH3 and cysteine-rich domain-containing protein

SRC homology 3 and cysteine-rich domain-containing protein

STAC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STAC	Q99469	KIAA1958	Homo sapiens	Q8N8K9	Y2H Prey Pooling	32296183
Intra	STAC	Q99469	KIAA1958	Homo sapiens	Q8N8K9	Y2H Array	32296183
Intra	STAC	Q99469	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Prey Pooling	32296183
Intra	STAC	Q99469	NCKIPSD	Homo sapiens	Q9NZQ3-3	Validated Y2H	32296183
Intra	STAC	Q99469	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Array	32296183
Intra	STAC	Q99469	STAT5B	Homo sapiens	P51692	Y2H Prey Pooling	32296183
Intra	STAC	Q99469	STAT5B	Homo sapiens	P51692	Y2H Array	32296183
Intra	STAC	Q99469	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	STAC	Q99469	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	STAC	Q99469	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	STAC	Q99469	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	STAC	Q99469	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	STAC	Q99469	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	STAC	Q99469	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	STAC	Q99469	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	STAC	Q99469	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	STAC	Q99469	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	STAC	Q99469	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	STAC	Q99469	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
Intra	STAC	Q99469	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
Intra	STAC	Q99469	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	STAC	Q99469	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	STAC	Q99469	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	STAC	Q99469	YWHAE	Homo sapiens	P62258	Peptide Array	16260042
Intra	STAC	Q99469	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	33961781
Intra	STAC	Q99469	YWHAE	Homo sapiens	P62258	Anti Bait CoIP	16260042
Intra	STAC	Q99469	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	28514442
Intra	STAC	Q99469	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	STAC	Q99469	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	STAC	Q99469	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	STAC	Q99469	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	STAC	Q99469	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	STAC	Q99469	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	STAC	Q99469	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	STAC	Q99469	RNF208	Homo sapiens	Q9H0X6	Y2H Array	32296183
Intra	STAC	Q99469	RNF208	Homo sapiens	Q9H0X6	Y2H Prey Pooling	32296183
Intra	STAC	Q99469	RNF208	Homo sapiens	Q9H0X6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Exudative Vitreoretinopathy 6

EVR6	Vitreoretinopathy, Exudative 6
Vitreoretinopathy, Exudative, Type 6

Myopathy, Congenital, Bailey-Bloch

Native American Myopathy	Nam
MYPBB	Myopathy, Congenital, Baily-Bloch
Anti-Hmg-Coa Myopathy	Anti-Srp Myopathy
Autoimmune Necrotizing Myositis	Imnm
Immune Myopathy With Myocyte Necrosis	Immune-Mediated Necrotizing Myopathy
Myopathy, Congenital, With Myopathic Facies, Scoliosis, And Malignant Hyperthermia	Necrotizing Autoimmune Myopathy
Congenital Myopathy-Cleft Palate-Malignant Hyperthermia Syndrome	Congenital Myopathy With Cleft Palate And Malignant Hyperthermia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16558	Butein		99.95%	Unkown
HY-114981	SRTCX1002	Activator	/	Unkown
HY-RS13863	STAC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13864	STAC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13865	STAC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	STAC	RGD	RGD:1305745
Bos taurus	STAC	VGNC	VGNC:35350
Macaca mulatta	STAC	VGNC	VGNC:77900
Canis familiaris	STAC	VGNC	VGNC:46870
Mus musculus	STAC	MGD	MGI:1201400
Felis catus	STAC	VGNC	VGNC:65741
Others	STAC	NCBI

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