GCFC2 - GC-rich sequence DNA-binding factor 2 Gene

Homo sapiens

Also known as GCF; TCF9; DNABF; C2orf3

Gene ID: 6936 | Gene type: protein coding

About GCFC2

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:75,662,705-75,713,122 (from NCBI)

This gene has 11 transcripts (splice variants), 242 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 5.0), testis (RPKM 4.3) and 25 other tissues.

Summary

The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene. [provided by RefSeq, Jul 2008]

GCFC2 Products(4)

mRNA	Protein	Name
NM_001201334.2	NP_001188263.1	intron Large complex component GCFC2 isoform 2
NM_001201335.2	NP_001188264.1	intron Large complex component GCFC2 isoform 3
NM_001410845.1	NP_001397774.1	intron Large complex component GCFC2 isoform 4
NM_003203.5	NP_003194.3	intron Large complex component GCFC2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24304693	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in spliceosomal complex assembly	IMP IMP: Inferred from mutant phenotype	24304693	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2-type post-mRNA release spliceosomal complex	IDA IDA: Inferred from direct assay	24304693	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	24304693	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24304693	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCFC2 Protein Structure

GCFC

0
200
400
600
781 a.a.

Protein Preferred Names

Protein Names

intron Large complex component GCFC2

GC binding factor

GCFC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GCFC2	P16383	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	GCFC2	P16383	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	GCFC2	P16383	TFIP11	Homo sapiens	Q9UBB9	Anti Tag CoIP	24304693
Intra	GCFC2	P16383	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Dyslexia

Reading Disorder

Specific Reading Disorder	Reading
Dyslexia	Developmental Reading Disorder

Learning Disability

Learning Disabilities	Learning Disorders
Academic Skill Disorder	Learning Disorder

Specific Language Impairment

Language Impairment, Specific

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05322	GCFC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GCFC2	VGNC	VGNC:62490
Mus musculus	GCFC2	MGD	MGI:2141656
Rattus norvegicus	GCFC2	RGD	RGD:1304792
Canis familiaris	GCFC2	VGNC	VGNC:41142
Bos taurus	GCFC2	VGNC	VGNC:29283
Macaca mulatta	GCFC2	VGNC	VGNC:72715

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