2. Gene
  3. THOP1 - thimet oligopeptidase 1 Gene

THOP1 - thimet oligopeptidase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TOP; MP78; EP24.15; MEPD_HUMAN

Gene ID: 7064 | Gene type: protein coding

About THOP1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,785,503-2,815,807 (from NCBI)

This gene has 14 transcripts (splice variants), 205 orthologues and 2 paralogues. Broad expression in testis (RPKM 14.1), brain (RPKM 6.4) and 24 other tissues.

Summary

The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic Peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic Peptides. [provided by RefSeq, Nov 2015]

THOP1 Products(1)

mRNA Protein Name
NM_003249.5 NP_003240.1 thimet oligopeptidase
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19614740 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THOP1 Protein Structure

Peptidase_M3

Peptidase_M3: Peptidase family M3 (227 - 675)

  • 0
  • 200
  • 400
  • 600
  • 689 a.a.
Protein Preferred Names Protein Names

thimet oligopeptidase

endopeptidase 24.15

Recombinant THOP1 Proteins

Cat. No. Product Name Accession Purity
HY-P71359 THOP1 Protein, Human (His) P52888 (K2-C689) ≥95%

Related Diseases

Diseases Alias
Methemoglobinemia And Ambiguous Genitalia

METAG

Methemoglobinemia Type Iv

Isolated 17,20-Lyase Deficiency, Pure

Methemoglobinemia Due To Deficiency Of Cytochrome B5

Methemoglobinemia Type 4

Methemoglobinemia Type Iv, Formerly

Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly

Pure Isolated 17,20-Lyase Deficiency

Methemoglobinemia, Type Iv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14497 THOP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris THOP1 VGNC VGNC:47353
Felis catus THOP1 VGNC VGNC:66170
Macaca mulatta THOP1 VGNC VGNC:78347
Bos taurus THOP1 VGNC VGNC:35843
Mus musculus THOP1 MGD MGI:1354165
Rattus norvegicus THOP1 RGD RGD:68330
Others THOP1 NCBI